Abstract:A liquid chromatography–tandem mass spectrometry method was developed to determine nine types of capsid proteins simultaneously in nine‐valent human papillomavirus vaccines. Signature peptides were optimized in terms of specificity, repeatability, determination accuracy and sensitivity. As a result, three signature peptides per capsid protein were obtained. The linear calibration curves were achieved in the range of 11.6–373.6 nmol/L (R2 > 0.998). Compared to our previous liquid chromatography–tandem mass spec… Show more
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