Simultaneous determination of dynamic cardiac metabolism and function using PET/MRI

Abstract

PET/MR with continuous FDG infusion captures dynamic changes in both cardiac metabolism and contractile function. This technique warrants evaluation in human cardiac disease for assessment of subtle functional and metabolic abnormalities.

Development of a PET/MRI exercise stress test for determining cardiac glucose dependence in pulmonary arterial hypertension

“…The novelty of this study is the utilization of dynamic PET acquisition and the use of two mini boluses of 18F‐FDG, which serves two purposes. In concert with dynamic PET acquisition, the use of two bolus injections (i.e., at rest and just before exercise) permits the quantification of real‐time RV and LV glucose uptake using kinetic modeling 6 , 7 during a serial rest‐stress protocol. Future work utilizing this PET/MRI technique in PAH patients should assess whether greater RV glucose dependency at baseline or during therapy is an independent predictor of adverse outcomes.…”

“…PET images were manually segmented (ITK‐SNAP analysis software). 5 Plasma time–activity curves were determined from the PET LV blood pool and Patlak analysis was used to determine RV and left ventricular (LV) glucose uptake rates ( K i ), 6 , 7 to determine the ratio of RV/LV K i as previously described 8 (Figure 1b ).…”

Increased [18F]FDG uptake in the infarcted myocardial area displayed by combined PET/CMR correlates with snRNA-seq-detected inflammatory cell invasion

“…Similar to other animal studies with myocardial [ 18 F]FDG PET, we have not used dietary restrictions or insulin administration to avoid the metabolic imbalance in the anesthetized animals undergoing PET/MRI investigation [2,34,52,63,65]. Second, indeed, various anesthetic agents are used as premedication or during porcine [ 18 F]FDG PET investigations (telazol, xylazine, isoflurane, propofol, diazepam, and fentanyl) [2,34,52,63,65]. Anesthesia and anesthetic agents influence [ 18 F]FDG uptake in various tissues in anesthetized animals.…”

Value of simultaneous assessment of cardiac functions by PET/MRI

“…Barton et al assessed the dynamic relationship between contractile function and metabolism during normoxia followed by hypoxia in pig model. 13 Hypoxic stress induced a significant increase in heart rate, cardiac output, left ventricular (LV) ejection fraction (EF), and peak torsion with decrease in LV end-diastolic and endsystolic volumes assessed by MRI associated with decline in arterial Sp O 2 : Increased LV systolic function was coupled with an increase in myocardial FDG uptake (Ki) during hypoxic stress on dynamic PET study.…”