1977
DOI: 10.1016/0022-4731(77)90199-6
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Simultaneous determination of eight adrenal steroids in human serum by radioimmunoassay

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Cited by 50 publications
(14 citation statements)
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“…Inhibition of the conversion of angiotensin I to angiotensin II by captopril is the most probable reason for the fall in aldosterone and 18-hydroxycorticosterone. This may support the hypothesis that aldosterone and 18-hydroxycorticosterone are more sensitive to changes of angiotensin II levels than corticosterone and 18-hydroxydeoxycorticosterone which are mainly regulated by corticotropin (21,26). The inhibition of prostaglandin biosynthesis by indometacin was accompanied by a significant decrease of all control steroid levels during active orthostasis, which may be due to the inhibition of the adrenocortical prostaglandin system.…”
Section: Studies In Human Volunteerssupporting
confidence: 75%
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“…Inhibition of the conversion of angiotensin I to angiotensin II by captopril is the most probable reason for the fall in aldosterone and 18-hydroxycorticosterone. This may support the hypothesis that aldosterone and 18-hydroxycorticosterone are more sensitive to changes of angiotensin II levels than corticosterone and 18-hydroxydeoxycorticosterone which are mainly regulated by corticotropin (21,26). The inhibition of prostaglandin biosynthesis by indometacin was accompanied by a significant decrease of all control steroid levels during active orthostasis, which may be due to the inhibition of the adrenocortical prostaglandin system.…”
Section: Studies In Human Volunteerssupporting
confidence: 75%
“…thin layer or column chromatography with silica gel)-in this context exposure to organic solvents is shortened by the described assay. In recently published multiple assays at least two extractions and Chromatographie separations were necessary before radioimmunoassay (20)(21)(22).…”
Section: Discussionmentioning
confidence: 99%
“…In 14 plasma samples with an aldosterone concentration between 0.1 and 3.7 nmol/ L, measurements with the kit were 5 to 15% higher than those obtained with a more laborious procedure including paper chromatography prior to the radioimmunoassay. 15 The coefficient of correlation between the two methods was 0.967 {p < 0.001). The sensitivity of the direct assay was 0.07 nmol/ L. The intra-assay variability at 0.85 nmol/L was 8.2% (n = 10).…”
mentioning
confidence: 98%
“…There have been several reports concerning the simultaneous determination of ALDO and the series of intermediates in its biosynthetic pathways from progesterone Schoeneshoefer et al, 1977: Sippell et al, 1978: Ojima et al, 1978. However, none described the findings on 180H-B which had been known to be an immediate intermediate in ALDO synthesis (Fraser and Lantos, 1978) and none described their dynamics in mother and fetus during pregnancy and labor.…”
Section: Discussionmentioning
confidence: 99%