Simultaneous Determination of Eight Chemical Components in Angelicae Sinensis Radix and Its Herbal Products by QAMS

Zhang, Yu; Li, Qian; Feng, Yu; Liu, Yang; Wang, Qi; Guo, Yinlong; Qiu, Daiyu

doi:10.1155/2021/7178982

Cited by 8 publications

(2 citation statements)

References 18 publications

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“…Baicalein pada radix paeoniae rubra dapat meningkatkan ekspresi EPO melalui jalur persinyalan phosphatidylinositol 3-kinase (PI3K) pada neuron dan astrosit korteks serebri tikus Sun et al, 2013). Rhizoma chuanxiong dan Radix angelicae sinensis memiliki kandungan chlorogenic acid, ferulic acid, dan ligustilide (Zhang et al, 2021). Chlorogenic acid pada memiliki kemampuan untuk meningkatkan EPO pada otak tikus model iskemik reperfusi (Miao et al, 2017).…”

Section: Pengaruh Mlc901 Terhadap Rdwunclassified

Effect of MLC901 on Red Cell Distribution Width (RDW) in Acute Ischemic Stroke: Literature Review

Ilham,

Hunaifi,

Dirja

2024

JBT

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Acute ischemic stroke is an acute episode of neurological dysfunction caused by focal infarction or damage that persists for ≥24 hours in the brain, spine, and retinal. Stroke is the second highest cause of death worldwide. The total prevalence of stroke continues to increase in the world and in Indonesia. However, stroke treatment is still less effective, so adjuvant therapy needs to be developed; one of them is MLC901. However, this therapy still needs to be studied further regarding its effect on acute ischemic stroke and the biomarkers used as the prognostic factors, such as red cell distribution width (RDW). This paper aims to determine the effect of MLC901 therapy on RDW values in acute ischemic stroke by analyzing various previous studies from different databases as a reference. Increased RDW values are associated with poor outcomes of acute ischemic stroke. MLC901 was shown to have neuroprotective and neurorestorative abilities in neurons that are under stress due to ischemia. MLC901 also can reduce inflammatory responses, reduce oxidative stress, and increase erythropoietin (EPO) production. So, administration of adjuvant MLC901 therapy can reduce RDW values and improve neurological outcomes in acute ischemic stroke.

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Section: Pengaruh Mlc901 Terhadap Rdwunclassified

Effect of MLC901 on Red Cell Distribution Width (RDW) in Acute Ischemic Stroke: Literature Review

Ilham,

Hunaifi,

Dirja

2024

JBT

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“…The main ingredient of the Xinmailong injection is a nucleoside extracted and purified from the American cockroach, which has a protective effect on the cardiovascular system. As early as 1964, Japanese scholars had discovered the hypolipidemic effects of mushrooms and extracted the effective ingredient, a mushroom purine (Zhang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Quantitative multicomponent analysis of a single marker–based simultaneous determination and quality assessment of nucleoside analogs from Qi Zhi capsules

Bai

Wang

Yang

et al. 2022

Biomedical Chromatography

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Qi Zhi capsule (QZC) is approved by the State Drug Administration of China. The QZC consists of nine crude drugs, including astragalus, leeches, ground beetles, curcuma zedoary, hawthorn, semen cassiae, rhizoma sparganii, polygonum multiflorum, and peach kernel, of which leeches and ground beetles are Traditional Chinese Medicine of animal origin. Nucleosides are animal substances with pharmacological effects that are easy to extract and quantify. Different nucleoside analogs in distinct animal‐based formulations can be used to characterize animal‐based medicines. However, the quality control of a single indicator does not reflect the overall quality of Chinese medicine. Here, we developed a method to simultaneously determine the nucleoside analogs uracil, xanthine, hypoxanthine, uridine, guanine, and uric acid in QZCs using high‐performance liquid chromatography. Hypoxanthine was used as an internal reference to determine relative correction factors for the other five components. The six components were determined in ten different batches of QZCs. There was no significant difference between the quantitative multicomponent analysis of a single marker and the external standard method. The relative standard deviation of total nucleosides analogs of 10 batches of samples was 7%. This method can be applied to simultaneously determine multiple active components in QZCs and other nucleoside analog drugs, enabling multi‐indicator quality control.

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Library-based UHPLC-Q-exactive-orbitrap-MS putative identification of isomeric and non-isomeric bioactives from Zibushengfa Tablet and pharmacopeia quality-marker chemistry

Chen

Zeng

et al. 2023

Journal of Liquid Chromatography & Related Technologies

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Simultaneous Determination of Eight Chemical Components in Angelicae Sinensis Radix and Its Herbal Products by QAMS

Cited by 8 publications

References 18 publications

Effect of MLC901 on Red Cell Distribution Width (RDW) in Acute Ischemic Stroke: Literature Review

Effect of MLC901 on Red Cell Distribution Width (RDW) in Acute Ischemic Stroke: Literature Review

Quantitative multicomponent analysis of a single marker–based simultaneous determination and quality assessment of nucleoside analogs from Qi Zhi capsules

Library-based UHPLC-Q-exactive-orbitrap-MS putative identification of isomeric and non-isomeric bioactives from Zibushengfa Tablet and pharmacopeia quality-marker chemistry

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