Simultaneous determination of eight estrogens and their metabolites in serum using liquid chromatography with electrochemical detection

Inhibition of Human Liver Aldehyde Oxidase: Implications for Potential Drug-Drug Interactions

“…This site may have its conformation altered by the presence or absence of substrate at the active site, such that the affinity for (Westhoff et al, 2010). b In pregnant women (Piwowarska et al, 2010). c For patients given a 150-mg dose twice a day for 7 days (Brunton et al, 2006).…”

Critical period for dopaminergic neuroprotection by hormonal replacement in menopausal rats

“…For analysis of blood levels of 17b-estradiol by HPLC (Fernandez et al, 1993;Piwowarska et al, 2010), blood was treated with 10M NaOH (0.5 mL by mL of blood) and then shaken for 5 minutes. The mixture was then extracted with 5 mL of diethyl ether by rotomixing for 10 minutes.…”

Reduced graphene oxide-Sb2O5 hybrid nanomaterial for the design of a laccase-based amperometric biosensor for estriol

“…The selected target analyte to evaluate the suitability of the hybrid nanomaterial-based biosensor was estriol ((16α,17β)-estra-1,3,5(10)-triene-3,16,17-triol), a phenolic estrogen hormone widely used in the treatment of urogenital diseases in menopausal women. This drug, classified as endocrine disrupting compound [18,19], is commonly eliminated in the urine of patients and is not completely degraded during the treatment of sewage becoming a potential environmental risk [20]. The determination of estriol in human and environmental samples has been mainly performed by gas and liquid chromatography [19,[21][22][23] and spectrophotometric techniques [24][25][26], but these analytical procedures require exhaustive pre-treatment of samples prior to analysis.…”

“…This drug, classified as endocrine disrupting compound [18,19], is commonly eliminated in the urine of patients and is not completely degraded during the treatment of sewage becoming a potential environmental risk [20]. The determination of estriol in human and environmental samples has been mainly performed by gas and liquid chromatography [19,[21][22][23] and spectrophotometric techniques [24][25][26], but these analytical procedures require exhaustive pre-treatment of samples prior to analysis. Several authors have proposed electroanalytical techniques as reliable alternatives for estriol detection [18,20,27], and succesful results have been achieved by using proper combination of new advanced materials and highly selective bioreceptor on the transducer interfase.…”