The objective of this study is to novel ‘high performance liquid chromatography’ method this is sensitivity and accurates, with focus on specificity, for measuring the amount of Flupenthixoland Escitalopramin bulk dosage form and pharmaceutical formulation. Methods: Drug and its impurities were separated chromatographically using C18(AGILENT) coloumn together with a methanol-based mobile phase and 0.1% TFAA (pH4.2 WITH TEA) at a flow rate of one milliliter per min in the ratio 65;35, with UV detection 235nm. Results: With good resolution, Flupenthixol and Esitalopram were successfully eluted during the retention period off 3.044 and 4.118 min, Respectivaly. The described method showed a linear relationship across the flupenthixol concentration range. (200-100ug/ml) and esitalopram (1-5 g/ml). Flupenthixol and Esitalopram were found to have 100%–102% recoveries. When validating the method, the ICH guidelines were adhered to. Excellent precision, accuracy, linearity, specificity, sensitivity, and robustness were demonstrated by the validation results. Conclusion: The proposed method effectively separated and quantified escitalopram and flupentixol. This developed technique is totally analysissure suitable for routine analysis ofEscitalopram and Flupenthixol in dosage of pharmaceuticals formulation.