Simultaneous determination of free biliverdin and free bilirubin in serum: A comprehensive LC-MS approach

Albreht, Alen; Martelanc, Mitja; Žiberna, Lovro

doi:10.1016/j.aca.2023.342073

Analytica Chimica Acta

2024

DOI: 10.1016/j.aca.2023.342073

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Simultaneous determination of free biliverdin and free bilirubin in serum: A comprehensive LC-MS approach

Alen Albreht,

Mitja Martelanc,

Lovro Žiberna

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Cited by 6 publications

References 46 publications

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N121T and N121S substitutions on the SARS‐CoV‐2 spike protein impact on serum neutralization

Lo,

Lim,

Jang

et al. 2024

Journal of Medical Virology

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The N121 site on the spike protein of SARS‐CoV‐2 is associated with heme and its metabolite, biliverdin, which can affect antibody binding. Both N121T and N121S substitutions have been observed in natural conditions and in a hamster model of dual infection with SARS‐CoV‐2 and Influenza A virus. Serum pseudotype neutralization assays against HIV‐1 particles carrying wild‐type, N121T, and N121S spikes with immune mouse and human sera revealed that N121T and N121S mutations had a greater impact on serum neutralization than biliverdin treatment. Although N121T and N121S substitutions are not currently major SARS‐CoV‐2 variants of concern, this study could provide fundamental information to prepare for potential future mutations at the N121 site of SARS‐CoV‐2.

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N121T and N121S substitutions on the SARS‐CoV‐2 spike protein impact on serum neutralization

Lo,

Lim,

Jang

et al. 2024

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

Bilirubin: Photophysical and photochemical properties, phototherapy, analytical methods of measurement. A short review

Tatikolov,

Pronkin,

Panova

2025

Biophysical Chemistry

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Simultaneous determination of canonical purine metabolism using a newly developed HILIC-MS/MS in cultured cells

Aihemaiti,

Liu,

Zou

et al. 2025

Journal of Pharmaceutical and Biomedical Analysis

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Simultaneous determination of free biliverdin and free bilirubin in serum: A comprehensive LC-MS approach

Cited by 6 publications

References 46 publications

N121T and N121S substitutions on the SARS‐CoV‐2 spike protein impact on serum neutralization

N121T and N121S substitutions on the SARS‐CoV‐2 spike protein impact on serum neutralization

Bilirubin: Photophysical and photochemical properties, phototherapy, analytical methods of measurement. A short review

Simultaneous determination of canonical purine metabolism using a newly developed HILIC-MS/MS in cultured cells

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