Simultaneous determination of lercanidipine, benazepril and benazeprilat in plasma by LC–MS/MS and its application to a toxicokinetics study

Chen, Keguang; Zhang, Jing; Liu, Sha; Zhang, Dujuan; Teng, Yuee; Wei, Chen; Wang, Benjie; Liu, Xiaoyan; Yuan, Gang; Zhang, Rui; Zhao, Wenjing; Guo, Rongbo

doi:10.1016/j.jchromb.2012.04.014

Cited by 14 publications

(11 citation statements)

References 24 publications

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“…8(b)]. Our results agree with previous reports [4,13]. Again, the two compounds look very similar, especially Mn 3d states appearing at −3 eV from majority spins and 1 eV from minority spins, and Te 5p states dominating at the valence-band maximum with some admixture with Mn 3d states.…”

Section: Dft Calculationssupporting

confidence: 91%

“…Again, the two compounds look very similar, especially Mn 3d states appearing at −3 eV from majority spins and 1 eV from minority spins, and Te 5p states dominating at the valence-band maximum with some admixture with Mn 3d states. While the low-energy part of the conduction band is dominated by Mn 3d minority spin states with some admixture with Bi 6p or Sb 5p states, there is a noticeable difference between MnBi 2 Te 4 Gray lines are the total DOS, other lines are partial DOS; blue is Te1, light blue is Te2, red is Mn, and green is Bi or Sb. Density functional theory calculations include antiferromagnetic ordering with the spin-orbit coupling as described in the text.…”

Section: Dft Calculationsmentioning

confidence: 99%

“…Intrinsic magnetic topological insulators are ideal for realizing exotic quantum states of matter such as an axion insulator and the quantum anomalous Hall effect at elevated temperatures. It has recently been proposed that MnBi 2 Te 4 is the first example of an antiferromagnetic topological insulator [1,2], which has immediately triggered extensive theoretical and experimental studies on bulk, thin films, and thin flakes [3][4][5][6][7][8][9][10][11]. As shown in the inset of Fig.…”

Section: Introductionmentioning

confidence: 99%

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Evolution of structural, magnetic, and transport properties in MnBi2−xSbxTe4

et al. 2019

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Here we report the evolution of structural, magnetic, and transport properties in MnBi2−xSbxTe4(0≤x≤2) single crystals. MnSb2Te4, isostructural to MnBi2Te4, is successfully synthesized in single-crystal form. Magnetic measurements suggest an antiferromagnetic order below TN=19K for MnSb2Te4 with the magnetic moments aligned along the crystallographic c axis. With increasing Sb content in MnBi2−xSbxTe4, the a-lattice parameter decreases linearly following Vegard's law, while the c-lattice parameter shows little compositional dependence. The contraction along a is caused by the reduction of the Mn-Te-Mn bond angle, while the Mn-Te bond length remains nearly constant. The antiferromagnetic ordering temperature slightly decreases from 24 K for MnBi2Te4 to 19 K for MnSb2Te4. More dramatic change was observed for the critical magnetic fields required for the spin-flop transition and the moment saturation. Both critical fields decrease with increasing Sb content for x≤1.72; a spin-flip transition occurs in MnSb2Te4 at a small field of 3 kOe applied along the c axis. In high magnetic fields, the saturation moment at 2 K shows significant suppression from 3.56μB/Mn for MnBi2Te4 to 1.57μB/Mn for MnSb2Te4. Analysis of the magnetization data suggests that both the interlayer magnetic interaction and single-ion anisotropy decrease with increasing Sb content for x≤1.72. The partial substitution of Bi by Sb also dramatically affects the transport properties. A crossover from n-type to p-type conducting behavior is observed around x≈0.63. Our results show close correlation between structural, magnetic, and transport properties in MnBi2−xSbxTe4 and that partial substitution of Bi by Sb is an effective approach to fine tuning both the magnetism and transport properties of MnBi2−xSbxTe4.

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Section: Dft Calculationssupporting

confidence: 91%

Section: Dft Calculationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evolution of structural, magnetic, and transport properties in MnBi2−xSbxTe4

et al. 2019

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“…The review of the literature revealed that few methods have been reported for the determination of the LCP in human plasma and pharmaceutical formulation namely capillary electrophoresis (CE), high‐performance liquid chromatography (HPLC), and liquid chromatography–mass spectrometry . However, these methods are expensive and require sophisticated instrumentation, highly skilled personnel, and time‐consuming extraction procedures which restrict their use in routine analysis.…”

Section: Introductionmentioning

confidence: 99%

A sensitive voltammetric sensor based on synergistic effect of graphene–polyaniline hybrid film for quantification of calcium antagonist lercanidipine

Jain

Tiwari

Shrivastava

2014

J of Applied Polymer Sci

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A chemically modified sensor based on the synergistic effect of graphene and polyaniline for electrochemical sensing of calcium antagonist lercanidipine (LCP) has been developed. Scanning electron microscopy, electrochemical impedance spectroscopy, square-wave voltammetry, and cyclic voltammetry were utilized to characterize the morphology and electroanalytical performance of the fabricated sensor. Under optimized conditions, reduction peak current was linear over the wide concentration range from 5 to 125 ng mL 21 with correlation coefficient of 0.9998. The limit of detection and the limit of quantification were found to be 1.94 and 5.89 ng mL 21 . The developed sensor also exhibited good reproducibility and long-term stability. In addition, the proposed method was successfully applied to the determination of LCP in pharmaceutical formulation which is proved by recovery studies. Graphenepolyaniline composites are expected to be promising material for biosensing applications because of the ease of fabrication, excellent electrochemical performance, and high electroactive surface area.

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“…Plasma concentrations of BH, BZ, and IS (enalapril) were extracted from plasma and determined using the established methods (Chen et al, 2012;Rezk & Badr, 2014).…”

mentioning

confidence: 99%

Development of a new benazepril hydrochloride chewable tablet and evaluation of its bioequivalence for treatment of heart failure in dogs

Qian

Chen

Zhou

et al. 2015

Vet Pharm & Therapeutics

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The aim of the study was to develop a new chewable benazepril hydrochloride(BH) tablet, investigate its physical properties, and evaluate its bioequivalence with the branded formulation (Fortekor). A corrective agent was included in the formula to improve its palatability and convenience for administration to dogs. The tablet remained stable in light, heat, and humidity tests, and its physical properties such as hardness, uniformity of content, and dissolution rate were highly consistent with the technical standards. After single and repeated administrations to eight beagles and single dose to 14 mongrel dogs (0.5 mg/kg p.o.), plasma BH and its active metabolite, benazeprilat (BZ), were detected. There was no significant difference in the major pharmacokinetic parameters (Cmax , Tmax, and AUC₀₋₂₄) between the two formulations. The 90% confidence intervals calculated for the ratios of area under the time-concentration curve (AUC₀₋₂₄) were 92.4-116.3% for BH and 89.9-102.3% for BZ, within the accepted range for bioequivalence of 80-125%. The results showed our new chewable tablet is bioequivalent to the commercial product and suitable for addition to the benazepril product family for the treatment of heart failure in dogs.

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Simultaneous determination of lercanidipine, benazepril and benazeprilat in plasma by LC–MS/MS and its application to a toxicokinetics study

Cited by 14 publications

References 24 publications

Evolution of structural, magnetic, and transport properties in MnBi2−xSbxTe4

Evolution of structural, magnetic, and transport properties in MnBi2−xSbxTe4

A sensitive voltammetric sensor based on synergistic effect of graphene–polyaniline hybrid film for quantification of calcium antagonist lercanidipine

Development of a new benazepril hydrochloride chewable tablet and evaluation of its bioequivalence for treatment of heart failure in dogs

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