Simultaneous determination of paracetamol, pseudoephedrine, dextrophan and chlorpheniramine in human plasma by liquid chromatography–tandem mass spectrometry

Analysis of Paracetamol, Pseudoephedrine and Brompheniramine in Comtrex® Tablets Using Chemometric Methods

“…[2,3] PAR is official in the British pharmacopoeia (BP). [4] Literature survey revealed that PAR alone or in combination with other drugs was determined by titrimetry, [4,5] spectrophotometry, [6][7][8][9][10][11][12] spectrofluorimetry, [13] thin layer chromatography (TLC), [14][15][16] GC, [17] HPLC-UV, [18][19][20][21][22][23] HPLC-MS/MS [24] and capillary electrophoresis (CE). [25][26][27] PSE; [(+)-threo-a-[1-methylamino) ethyl] benzyl alcohol] hydrochloride, is a sympathomimetic amine which directly acts on the adrenergic receptor system.…”

Multi-component quantitation of loratadine, pseudoephedrine and paracetamol in plasma and pharmaceutical formulations with liquid chromatography-tandem mass spectrometry utilizing a monolithic column

“…LC-MS/MS in particular, is the most popular analytical technique primarily because of its inherent selectivity and sensitivity. [5][6][7][8][9][10][11][12][13][14][15][16][17] The other techniques including capillary electrophoresis, ion-pair LC and ion mobility spectrometry have also been utilized for the determination of pseudoephedrine with other drugs in various biological and pharmaceutical samples. [18][19][20] Evaluations of monolithic columns have shown them to be equivalent to commercially available particle packed columns in terms of high binding capacity, high flow rates with low back pressure leading to fast separations, higher mass transfer kinetics, and increased efficiency.…”

“…The direct protein precipitation procedure is a robust, reliable and quick alternative for the determination of selected components as compared to multi-step sample processing procedures like liquid-liquid and solid phase extraction. Many articles are available reporting the simultaneous determination of LOR with Des-LOR, 5,6,15 PSE with LOR 7 and PSE with PAR or others 9,12,16 but to the best of our knowledge not a single method has been reported for the multi--component determination of all these components in plasma and pharmaceutical formulations utilizing a monolithic column.…”

Comparison of classic and derivative UV spectrophotometric methods for determination of dextromethorphani hydrobromidum

“…Due to the medical importance of DXM and its widespread use, several analytical methods have been employed for the determination of DXM in the bulk and in the dosage forms and in biological fluids. Most of those analytical methods imply chromatographic techniques, such as HLPC (Galli & Barbas, 2004, Lin et al, 2007, Santagati et al, 2005, HPLC-MS/MS (Lou et al, 2010, Zhang et al, 2010, GC-MS (Bagheri et al, 2005), and capillary electrophoresis (Dong et al, 2005, Yang et al, 2008. For the quantification of DXM, literature recommended either electrooxidation on a carbon nanotube--carbon microparticle liquid composite (Heli et al, 2010), or FIA with potentiometric detection (Khaled et al, 2010) and potentiometric membrane sensors (El-Naby, 2008).…”