Simultaneous determination of pharmaceutically active compounds in wastewater samples by solid phase extraction and high-performance liquid chromatography with diode array and fluorescence detectors

Santos, Juan Luís; Aparicio, Irene; Alonso, Esteban; Callejón, Manuel

doi:10.1016/j.aca.2005.06.064

Cited by 194 publications

(81 citation statements)

References 13 publications

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“…Concentrations of caffeine in influent samples were lower than 40.12 lg/ L, as can be seen in Table 5, and these high levels agree with Ternes et al [15] who found caffeine values as high as 147 lg/L in raw municipal wastewater. In influent samples of STPs, Santos et al [25] found maximum values of ibuprofen of 143 lg/L, and concentrations of naproxen, caffeine and carbamazepine below 16.3 lg/L. Like other authors [2,26] who have found that ibuprofen is the compound that is most removed from STPs, the results of our study showed significantly lower concentrations in effluent samples than in influent samples.…”

Section: Application To Environmental Samplescontrasting

confidence: 62%

Pharmaceutical determination in surface and wastewaters using high‐performance liquid chromatography‐(electrospray)‐mass spectrometry

Pedrouzo

Reverté

Borrull

et al. 2007

J of Separation Science

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A method was developed to determine 11 pharmaceutical compounds in water samples. The method uses SPE and HPLC coupled to MS (LC/MS) using ESI in both positive and negative modes. Three different sorbents were compared for the extraction of analytes from river and sewage treatment plant (STP) waters and OASIS HLB provided the best results. For the solid-phase extraction of 500 mL of river water samples, the recoveries were between 41 and 101% with the exception of acetaminophen, salicylic acid and naproxen. The LODs were between 3 and 5 ng/L for all the compounds, except naproxen which had an LOD of 15 ng/L. Acetaminophen, caffeine, carbamazepine, bezafibrate and ibuprofen were found in three of the tested river samples at ng/L levels and among them, the highest values were for caffeine and bezafibrate with 305 and 363 ng/L, respectively. For the influent and effluent water samples of the STP, volumes of 100 and 250 mL were used, respectively, to obtain acceptable recoveries. All the compounds showed recoveries between 33 and 91% for effluent samples and 33-72% for influent samples, with the exception of acetaminophen, salicylic acid and bezafibrate, which had lower recoveries. The method developed enabled pharmaceuticals in the influent and effluent sewage waters to be determined in five campaigns carried out between February 2004 and June 2005. Several pharmaceuticals were found in the influent samples: for instance, maximum concentrations of ibuprofen and caffeine were 6 and 40 microg/L, respectively.

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Section: Application To Environmental Samplescontrasting

confidence: 62%

Pharmaceutical determination in surface and wastewaters using high‐performance liquid chromatography‐(electrospray)‐mass spectrometry

Pedrouzo

Reverté

Borrull

et al. 2007

J of Separation Science

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“…Samples as pH and volume sample were optimized. For pH of the sample considering that most of the compound were from acidic nature, pH 7 and lower were tested since acidification of an aqueous solution is likely to reduce the dissociation of the weakly acidic analytes, which can improve the efficiency of extraction [14,15]. As can been seen in Figure 1, only IB show an increase in the chromatographic response when pH 5, while the other analytes have no significant difference at the pH interval.…”

Section: Spe Optimizationmentioning

confidence: 99%

Pharmaceutical Compounds Determination in Water Samples: Comparison Between Solid Phase Extraction and Stir Bar Sorptive Extraction

Suazo

Vásquez

Retamal

et al. 2017

J. Chil. Chem. Soc.

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A variety of organic compounds and their metabolites used in pharmaceutical and personal care products (PPCP´s) are continuously introduced into the environment by domestic or industrial wastewater. Solid phase extraction (polymeric dinivylbenzene cartridge) and stir bar sorptive extraction (polydimethylsiloxane phase) methodologies were optimized for the determination of some selected PPCP´s in aqueous matrices. Carbamazepine, β estradiol, 3-(4-methylbenzylidene) champhor, benzophenone-1 and ibuprofen were extracted from aqueous samples and methanol was used as conditioning/eluting solvent. The variables involved in the extraction of the analytes in the original sample were studied, pH between 3 and 6 and sample volume between 50 and 500 mL were considered. Three concentration levels were extracted at the optimal conditions of pH 5 and 500 mL of sample volume with a recovery up to 89%. The determination was performed in a GC-MS, and a derivatization step using BSTFA+TMCS (99:1) was needed previous to the injection. Real samples from Maipo River and Villarrica Lake were analyzed with the optimized method, and concentrations below the detection limit were detected.

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“…Contudo, os processos convencionais a que são submetidos os esgotos domésticos, baseados na degradação biológica dos contaminantes, não são eficientes para a completa remoção de fármacos residuais por possuírem ação biocida ou estruturas químicas complexas não passíveis de biodegradação, comprovado por diversos estudos que mostram a presença desse tipo de contaminante em efluentes de ETE. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Fármacos de diversas classes terapêuticas, como antibióticos, hormônios, antilipêmicos, antiinflamatórios, analgésicos, entre outros, têm sido detectados em esgoto doméstico, águas superficiais e subterrâneas em concentrações na faixa de ng L -1 a μg L -1 em várias partes do mundo (Tabela 1). …”

Section: Resíduos De Fármacos No Ambienteunclassified

Degradação de fármacos residuais por processos oxidativos avançados

Melo¹,

Trovó²,

Bautitz³

et al. 2009

Quím. Nova

186

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DegraDação De fármacos resiDuais por processos oxiDativos avançaDos silene alessandra santos melo, alam gustavo trovó, ivonete rossi Bautitz e raquel fernandes pupo nogueira* Departamento de Química Analítica, Instituto de Química de Araraquara, Universidade Estadual Paulista, CP 355, 14801-970 Araraquara -SP, BrasilRecebido em 19/12/07; aceito em 17/7/08; publicado na web em 5/12/08 DEGRADATION OF RESIDUAL PHARMACEUTICALS BY ADVANCED OXIDATION PROCESSES. The concern about aquatic ecosystems and the potential risk of drinking water contamination by pharmaceuticals have stimulated the study of processes for the efficient degradation of these contaminants, since the conventional treatment have been inefficient on that purpose. The advanced oxidation processes (AOPs) appear as viable alternatives due to their efficiency on the degradation of different classes of organic contaminants. This review presents an overview of the main AOP (O 3 , H 2 O 2 /UV, TiO 2 /UV, Fenton and photo-Fenton) which have been applied to the degradation of different pharmaceuticals. The main results obtained, intermediates identified and toxicity data are presented.

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Simultaneous determination of pharmaceutically active compounds in wastewater samples by solid phase extraction and high-performance liquid chromatography with diode array and fluorescence detectors

Cited by 194 publications

References 13 publications

Pharmaceutical determination in surface and wastewaters using high‐performance liquid chromatography‐(electrospray)‐mass spectrometry

Pharmaceutical determination in surface and wastewaters using high‐performance liquid chromatography‐(electrospray)‐mass spectrometry

Pharmaceutical Compounds Determination in Water Samples: Comparison Between Solid Phase Extraction and Stir Bar Sorptive Extraction

Degradação de fármacos residuais por processos oxidativos avançados

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