Simultaneous determination of pharmaceuticals and metabolites in fish tissue by QuEChERS extraction and UHPLC Q/Orbitrap MS analysis

Kalogeropoulou, Aggeliki G.; Kosma, Christina I.; Albanis, Triantafyllos A.

doi:10.1007/s00216-021-03684-y

Cited by 10 publications

(7 citation statements)

References 54 publications

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“…However, in some cases, fish were deboned [ 80 ], only the muscle was analysed [ 39 , 42 , 46 , 69 , 78 ] or the different body cavities were analysed separately (fillet, gills, liver, intestine or brain) [ 49 , 53 , 56 , 82 ]. In addition, usually the samples were freeze-dried, so that spraying in the absence of humidity would be easier, although several studies worked with wet weight [ 50 , 79 ]. In case of molluscs, cephalopods or crustaceans were generally pooled without differentiating body cavities, removed from the shell if present, freeze-dried and ground into powder [ 34 , 60 , 68 ].…”

Section: Analytical Methodologies For the Determination Of Pharmaceut...mentioning

confidence: 99%

“…Gao et al developed a different type of clean-up based on SPE [ 79 ]. These authors used a metal organic framework (MOF) as adsorbent.…”

Section: Analytical Methodologies For the Determination Of Pharmaceut...mentioning

confidence: 99%

“…After adsorption, desorption of the analytes takes place by using desorption solvents. Gao et al [ 79 ] used this adsorbent for the extraction of some analgesics such as ketoprofen, naproxen, flurbiprofen, diclofenac sodium and ibuprofen in fish and crustaceans’ tissue, achieving recoveries between 95 and 116.99% and LODs between 0.12 and 3.50 ng mL −1 .…”

Section: Analytical Methodologies For the Determination Of Pharmaceut...mentioning

confidence: 99%

“…RP-LC using C18 silica columns is mainly used for separation, although chiral columns based on α1-glycoprotein (AGP) and phenyl or phenyl-hexyl columns have been also used as stationary phases [ 44 , 73 , 78 ]. Generally, the most commonly used solvents in the mobile phase are water as the aqueous component (phase A), and in the organic phase, ACN or MeOH (phase B) [ 68 , 78 , 79 ]. Some authors such as Moreno-González et al used dichloromethane and methanol (90:20, v / v ) in isocratic mode as mobile phases for the analysis of 20 PhACs in fishes and molluscs, prior to a study of bioaccumulation [ 47 ].…”

Section: Instrumental Analysismentioning

confidence: 99%

“…After chromatographic separation, spectrophotometric detection has been used on a limited, but interesting, number of cases, depending on the properties of the compounds under study [ 96 ]. For example, Gao et al coupled an ultraviolet detection system for the determination of 5 NSAIDs in fish and shrimp muscle tissues using a new synthetic MOF in the extraction of the compounds, achieving LODs between 0.12 and 3.50 ng mL −1 [ 79 ]. It is a universal and inexpensive detector that is very useful for routine analysis.…”

Section: Instrumental Analysismentioning

confidence: 99%

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An Overview of Analytical Methods to Determine Pharmaceutical Active Compounds in Aquatic Organisms

et al. 2022

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There is increasing scientific evidence that some pharmaceuticals are present in the marine ecosystems at concentrations that may cause adverse effects on the organisms that inhabit them. At present, there is still very little scientific literature on the (bio)accumulation of these compounds in different species, let alone on the relationship between the presence of these compounds and the adverse effects they produce. However, attempts have been made to optimize and validate analytical methods for the determination of residues of pharmaceuticals in marine biota by studying the stages of sample treatment, sample clean-up and subsequent analysis. The proposed bibliographic review includes a summary of the most commonly techniques, and its analytical features, proposed to determine pharmaceutical compounds in aquatic organisms at different levels of the trophic chain in the last 10 years.

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Section: Analytical Methodologies For the Determination Of Pharmaceut...mentioning

confidence: 99%

“…Gao et al developed a different type of clean-up based on SPE [ 79 ]. These authors used a metal organic framework (MOF) as adsorbent.…”

Section: Analytical Methodologies For the Determination Of Pharmaceut...mentioning

confidence: 99%

Section: Analytical Methodologies For the Determination Of Pharmaceut...mentioning

confidence: 99%

Section: Instrumental Analysismentioning

confidence: 99%

Section: Instrumental Analysismentioning

confidence: 99%

See 3 more Smart Citations

An Overview of Analytical Methods to Determine Pharmaceutical Active Compounds in Aquatic Organisms

et al. 2022

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Application of Low‐ and High‐resolution Liquid Chromatography‐Mass Spectrometry for the Determination of Contaminants in Food Matrices

Boti,

Koloka,

Konstantinou

2024

Encyclopedia of Analytical Chemistry

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Food quality and safety are becoming a top priority to consumers, food suppliers, food manufacturers, and regulators as markets become more and more globalized. The use of liquid chromatography combined with mass spectrometry ( LC‐MS ) has proven to be incomparable in several ways in food analysis. Most of the effective LC‐MS methods currently used involve different MS analyzers, such as triple‐quadrupole ( QqQ ), ion‐trap ( IT ), time‐of‐flight ( TOF ), or orbitrap technology for the identification and quantification of contaminants in food commodities. The analysis of food matrices for the presence of contaminants belongs to the main application areas of these technologies and requires a thorough evaluation of their strength and limitations in order to secure scientific progress in this particular area of analysis. This article focuses on gathering the knowledge and comparing LC‐MS methodologies, applying both low‐ and high‐resolution mass analyzers, for the determination of contaminants in food matrices, with a particular focus on pesticides, veterinary drugs, and per‐ and polyfluoroalkyl substances ( PFAS ).

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Understanding LC/MS‐Based Metabolomics: A Detailed Reference for Natural Product Analysis

Sarkar,

Singh,

Chandel

2024

Proteomics Clinical Apps

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Liquid chromatography, when used in conjunction with mass spectrometry (LC/MS), is a powerful tool for conducting accurate and reproducible investigations of numerous metabolites in natural products (NPs). LC/MS has gained prominence in metabolomic research due to its high throughput, the availability of multiple ionization techniques and its ability to provide comprehensive metabolite coverage. This unique method can significantly influence various scientific domains. This review offers a comprehensive overview of the current state of LC/MS‐based metabolomics in the investigation of NPs. This review provides a thorough overview of the state of the art in LC/MS‐based metabolomics for the investigation of NPs. It covers the principles of LC/MS, various aspects of LC/MS‐based metabolomics such as sample preparation, LC modes, method development, ionization techniques and data pre‐processing. Moreover, it presents the applications of LC/MS‐based metabolomics in numerous fields of NPs research such as including biomarker discovery, the agricultural research, food analysis, the study of marine NPs and microbiological research. Additionally, this review discusses the challenges and limitations of LC/MS‐based metabolomics, as well as emerging trends and developments in this field.

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Simultaneous determination of pharmaceuticals and metabolites in fish tissue by QuEChERS extraction and UHPLC Q/Orbitrap MS analysis

Cited by 10 publications

References 54 publications

An Overview of Analytical Methods to Determine Pharmaceutical Active Compounds in Aquatic Organisms

An Overview of Analytical Methods to Determine Pharmaceutical Active Compounds in Aquatic Organisms

Application of Low‐ and High‐resolution Liquid Chromatography‐Mass Spectrometry for the Determination of Contaminants in Food Matrices

Understanding LC/MS‐Based Metabolomics: A Detailed Reference for Natural Product Analysis

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