Simultaneous determination of polyamines in human nail as 4-(N,N-dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole derivatives by nano-flow chip LC coupled with quadrupole time-of-flight tandem mass spectrometry

Min, Jun Zhe; Yano, Hiroya; Matsumoto, Akihito; Yu, Hai-fu; Shi, Qing; Higashi, Tatsuya; Inagaki, Shinsuke; Toyo’oka, Toshimasa

doi:10.1016/j.cca.2010.09.018

Cited by 30 publications

(27 citation statements)

References 18 publications

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“…We developed a simultaneous determination method for polyamines in human hair and nails by UPLC-ESI-TOF-MS, nano-flow chip LC-Q-TOF-MS [4,31]. The polyamines were labeled with DBD-F at 60 °C for 30 min in 0.1 M borax (pH 9.3).…”

Section: A Quantitative Analysis Of the Polyamine In Lung Cancer Patimentioning

confidence: 99%

“…In contrast, the human nail is relatively clean and the samples can be quickly and noninvasively collected and easily stored. Analyzing the components of nail provides an important means for determining the individual past history of long-term chemical exposures, because many substances have been detected in the nail [4][5][6][7][8]. Due to the stability of drugs in nails, many studies concerning nail analysis have dealt with drugs of abuse, such as cocaine, itraconazole and amphetamines [9,10].…”

Section: Introductionmentioning

confidence: 99%

“…According to recent reports, human nails may be used to obtain physiologic information, and may serve as a noninvasive bio sample for the diagnosis of chronic disease. Certain kinds of endogenous biogenic amino acids, polyamines and AGEs have been detected in the human nail [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Development of the High Sensitive Separation Analysis Method of Metabolites in Human Nail and its Application to the Diagnosis of Chronic Disease

Min

2014

Chromatography

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This review summarizes the possibility to diagnosing the chronic diseases and application of determination of metabolites of the noninvasive human nails. A target derivatization UPLC-ESI-MS method is a powerful tool for the analysis of bioactive compounds with high sensitivity and selectivity. We developed target derivatization UPLC-ESI-MS methods to analyze the biological trace components in human fingernail. Moreover, we have used these methods to detect the metabolites in human fingernails, such as DL-amino acids, polyamines and Advanced Glycation End products (AGEs). Through detecting the biological trace components in the real samples from human, we tested the possibility to use these new methods to diagnosing the chronic diseases, i.e., diabetes, lung cancer. Some applications utilizing these target derivatization methods for the analyses determination of metabolites in the human fingernails are also described in this paper.

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Section: A Quantitative Analysis Of the Polyamine In Lung Cancer Patimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of the High Sensitive Separation Analysis Method of Metabolites in Human Nail and its Application to the Diagnosis of Chronic Disease

Min

2014

Chromatography

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“…For instance, histamine and its metabolites in hair were easily labeled with DBD-F and determined by LC separation and time-of-flight (TOF)-MS detection. [18][19][20][21][22][23] The polyamines in the fingernail of lung-cancer patients were also determined after labeling with DBD-F and detected by LC-TOF-MS. 24 DBD-F was also applied to the determination of polyamines, including its N-acetylated form in the saliva of breast-cancer patients by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS). 25 The increase and decrease of specific polyamines were identified in breast-cancer patients.…”

Section: Reagents For Amines and Carboxylic Acidsmentioning

confidence: 99%

Derivatization-based High-throughput Bioanalysis by LC-MS

Toyo’oka

2017

ANAL. SCI.

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Liquid chromatography coupled with mass spectrometry (LC-MS) is one of the most prominent analytical techniques due to its inherent selectivity and sensitivity. LC-MS is currently the first choice for high-throughput bioanalysis due to the advancements in MS instruments and the analytical software. Based on this situation, we are developing various types of derivatization reagents, including chiral reagents for MS and/or MS/MS detection. These developed reagents are adopted for the detection of biomarker candidates related to diseases. The biomarker candidates include not only achiral molecules, but also chiral ones. Although determining the already-identified chiral molecules is relative easy, it is very difficult to identify and/or determine unknown enantiomer(s) in real samples. To solve this difficulty, we proposed a new strategy to identify unknown enantiomeric biomarkers related to diseases. This review paper deals with the development of derivatization reagents for amines and carboxylic acids in LC-MS analysis and their application to bioanalysis.

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“…Nowadays, the human fingernail has been generally accepted in the biomedical field due to the advantage of neatness, noninvasive collection and easily store. 14,15 At present, the diagnosis of chronic diseases relied on the physiologic information obtained by human nails regarded as a noninvasive bio sample. 16 …”

Section: Introductionmentioning

confidence: 99%

Development of Highly Sensitive Analysis Method for Histamine and Metabolites in Pregnant Women’s Fingernail by UPLC-ESI-MS

Uchibe

Shi

et al. 2018

ANAL. SCI.

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In this study, a highly sensitive analysis method for the rapid detection of histamine (HA), imidazole-4-acetic acid (IAA) and 1-methylhistamine (MHA) in pregnant women fingernails was developed by the ultra-performance liquid chromatography ( coefficient were found to be above 0.9998, the measured detection limit for derivatized histamine and metabolites ranged from 0.06 fmol to 0.15 fmol, and the relative standard derivations of intra-day and inter-day assay were 6.3%. Furthermore, the mean recoveries (%) of the standards added to human fingernails were in the range of 90.2-100.5%. The validatedmethod was successfully applied to analyze human fingernail samples from 3 pregnant women and 3 healthy women. The report about the detection of histamine and metabolites in the fingernails in pregnant women fingernails was the first published.

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Simultaneous determination of polyamines in human nail as 4-(N,N-dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole derivatives by nano-flow chip LC coupled with quadrupole time-of-flight tandem mass spectrometry

Cited by 30 publications

References 18 publications

Development of the High Sensitive Separation Analysis Method of Metabolites in Human Nail and its Application to the Diagnosis of Chronic Disease

Development of the High Sensitive Separation Analysis Method of Metabolites in Human Nail and its Application to the Diagnosis of Chronic Disease

Derivatization-based High-throughput Bioanalysis by LC-MS

Development of Highly Sensitive Analysis Method for Histamine and Metabolites in Pregnant Women’s Fingernail by UPLC-ESI-MS

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