Simultaneous Determination of Procaine Penicillin G and Benzathine Penicillin G by Second Derivative Spectrophotometry

Pulgarı́n, José A. Murillo; Molina, Aurelia Alañón; Rodríguez, José Manuel Fernández

doi:10.1080/00032719208016128

Analytical Letters

1992

DOI: 10.1080/00032719208016128

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Simultaneous Determination of Procaine Penicillin G and Benzathine Penicillin G by Second Derivative Spectrophotometry

José A. Murillo Pulgarı́n

Aurelia Alañón Molina

José Manuel Fernández Rodríguez

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Cited by 9 publications

References 13 publications

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Resolution of Ternary Mixture of Tartrazine, Quinoline Yellow and Sunset Yellow by Derivative Spectrophotometry and Ratio Spectra Derivative

Nevado¹,

Rodríguez²,

Llerena³

1993

Bulletin des Soc Chimique

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Two methods for determining the colorants Tartrazine (E-102), Quinoline Yellow (E-104)and Sunset Yellow (E-110) in mixtures are described. As first method was used the second derivative s ectrophotometry with measurement in the "zero-crossing" wavelengths. The second method, cafied "ratio spectrum zero crossing derivative", is based on the simultaneous use of the first derivative of ratio spectra and measurements at "zero-crossing" wavelengths. The two described procedures do not require any separation step. The calibrations gra hs are linear up to 20 pg/mL for Tartrazine, 40 pglmL for Sunset Yellow and 24 pg/mL for &noline Yellow in both methods. The methods are applied to determine these compounds in three food commercial products.

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Resolution of Ternary Mixture of Tartrazine, Quinoline Yellow and Sunset Yellow by Derivative Spectrophotometry and Ratio Spectra Derivative

Nevado¹,

Rodríguez²,

Llerena³

1993

Bulletin des Soc Chimique

Self Cite

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Stability Determination of 3‐Bromo‐2‐hydroxy‐N‐(3,4‐dimethyl‐5‐isoxazolyl)‐1,4‐naphthoquinon‐4‐imine in Ethanol by First‐Derivative Spectrophotometry

Dabbene

Briñón

Bertorello

1994

Journal of Pharmaceutical Sciences

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A sequential injection fluorometric procedure for the determination of procaine in human blood and pharmaceuticals

2006

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An automated procedure for the assay of procaine hydrochloride in human blood and pharmaceuticals was developed using a sequential injection (SI) technique with fluorometric detection and fluorescamine as the fluorescence probe. A few microliters of fluorescamine and procaine hydrochloride solutions were used in the SI system leading to the formation of a derivative, which was then excited by a 400-nm LED and whose emitted fluorescence was monitored at a wavelength of 494 nm. A linear calibration graph was obtained with 10-200 ng mL(-1) (procaine) by loading 10.0 microL of sample solution and 5.0 microL of fluorescamine solution (both 0.125 % m/v). A detection limit of 2.6 ng mL(-1), defined as 3 times the blank standard deviation (3sigma), was achieved along with a sampling frequency of 25 h(-1) and a precision of 2.1 % RSD at the 50.0 ng mL(-1) level. Procaine contents in injection solutions from various pharmaceutical manufactures were analyzed and reasonable agreement was achieved between the values obtained by using the present procedure and the documented spectrophotometry, and both were coincident with the nominal concentrations. In addition, the degradation of procaine in human blood was investigated. A fast degradation of procaine in human blood was observed for the first 30 min, while afterwards the degradation was retarded.

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Simultaneous Determination of Procaine Penicillin G and Benzathine Penicillin G by Second Derivative Spectrophotometry

Cited by 9 publications

References 13 publications

Resolution of Ternary Mixture of Tartrazine, Quinoline Yellow and Sunset Yellow by Derivative Spectrophotometry and Ratio Spectra Derivative

Resolution of Ternary Mixture of Tartrazine, Quinoline Yellow and Sunset Yellow by Derivative Spectrophotometry and Ratio Spectra Derivative

Stability Determination of 3‐Bromo‐2‐hydroxy‐N‐(3,4‐dimethyl‐5‐isoxazolyl)‐1,4‐naphthoquinon‐4‐imine in Ethanol by First‐Derivative Spectrophotometry

A sequential injection fluorometric procedure for the determination of procaine in human blood and pharmaceuticals

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