Simultaneous determination of progabide and its acid metabolite by reversed-phase high-performance liquid chromatography

Decourt, J; Mura, Paola; Papet, Yves; Piriou, Alain; Reiss, D.

doi:10.1016/s0378-4347(00)82103-9

Cited by 4 publications

(1 citation statement)

References 6 publications

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“…The method of Decourt et al (21) is modified and extended to a preparative scale. The deliverence under an appropriate pharmaceutical preparation is limited to a simple dilution with bidistilled water.…”

Section: Discussionmentioning

confidence: 99%

The synthesis of 4‐(4‐([¹¹C]methoxyphenyl) ‐(5‐fluoro‐2‐hydro‐xyphenyl)‐methylene‐aminobutyric acid, as a potential radioli‐gand for the gaba receptor in the brain

Vos

Slegers

1994

Labelled Comp Radiopharmac

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A procedure for the synthesis of 4-(4-[ llC]methoxyphenyl) -(5fluoro-2-hydroxyphenyl)-methylene-aminobutyr~c acid has been developed.The production entailed a 0-methylation of 5fluoro-2-hydroxy-4r-hydroxybenzophenone with cyclotron produced [llC]iodomethane in the presence of alkali and a subsequent Schif f reaction of 5-f luoro-2-hydroxy-4 -[ llC]methoxybenzophenone with y-aminobutyric acid. 5-Fluoro-2-hydroxy-4f-hydroxybenzophenone was obtained by a demethylation of the 4'-methoxyderivative with boron tribromide. Subsequent purification by HPLC and sterilisation by filtration gave 740 MBq(2O mci) of an injectable solution. The radiochemical yield (decaycorrected) from ['k] iodomethane achieved 27%. The specific activity was 3.7 GBq/pmo1(100 mCi/pmol) at the end of the radiosynthesis (45 min from EOB). The preparations have been demonstrated to be chemically and radiochemically pure by HPLC and TLC.

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Section: Discussionmentioning

confidence: 99%

The synthesis of 4‐(4‐([¹¹C]methoxyphenyl) ‐(5‐fluoro‐2‐hydro‐xyphenyl)‐methylene‐aminobutyric acid, as a potential radioli‐gand for the gaba receptor in the brain

Vos

Slegers

1994

Labelled Comp Radiopharmac

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High-performance liquid chromatographic determination of (4-[11C]methoxyphenyl)-(5-fluoro-2-hydroxyphenyl)-methyleneaminobutyric acid and its benzophenone metabolite

Vos

Slegers

1995

Journal of Chromatography A

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Mechanisms of the inhibition of human erythrocyte pyridoxal kinase by drugs

Lainé-Cessac

Cailleux

Allain

1997

Biochemical Pharmacology

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Simultaneous determination of progabide and its acid metabolite by reversed-phase high-performance liquid chromatography

Cited by 4 publications

References 6 publications

The synthesis of 4‐(4‐([¹¹C]methoxyphenyl) ‐(5‐fluoro‐2‐hydro‐xyphenyl)‐methylene‐aminobutyric acid, as a potential radioli‐gand for the gaba receptor in the brain

The synthesis of 4‐(4‐([¹¹C]methoxyphenyl) ‐(5‐fluoro‐2‐hydro‐xyphenyl)‐methylene‐aminobutyric acid, as a potential radioli‐gand for the gaba receptor in the brain

High-performance liquid chromatographic determination of (4-[11C]methoxyphenyl)-(5-fluoro-2-hydroxyphenyl)-methyleneaminobutyric acid and its benzophenone metabolite

Mechanisms of the inhibition of human erythrocyte pyridoxal kinase by drugs

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Simultaneous determination of progabide and its acid metabolite by reversed-phase high-performance liquid chromatography

Cited by 4 publications

References 6 publications

The synthesis of 4‐(4‐([11C]methoxyphenyl) ‐(5‐fluoro‐2‐hydro‐xyphenyl)‐methylene‐aminobutyric acid, as a potential radioli‐gand for the gaba receptor in the brain

The synthesis of 4‐(4‐([11C]methoxyphenyl) ‐(5‐fluoro‐2‐hydro‐xyphenyl)‐methylene‐aminobutyric acid, as a potential radioli‐gand for the gaba receptor in the brain

High-performance liquid chromatographic determination of (4-[11C]methoxyphenyl)-(5-fluoro-2-hydroxyphenyl)-methyleneaminobutyric acid and its benzophenone metabolite

Mechanisms of the inhibition of human erythrocyte pyridoxal kinase by drugs

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Product

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The synthesis of 4‐(4‐([¹¹C]methoxyphenyl) ‐(5‐fluoro‐2‐hydro‐xyphenyl)‐methylene‐aminobutyric acid, as a potential radioli‐gand for the gaba receptor in the brain

The synthesis of 4‐(4‐([¹¹C]methoxyphenyl) ‐(5‐fluoro‐2‐hydro‐xyphenyl)‐methylene‐aminobutyric acid, as a potential radioli‐gand for the gaba receptor in the brain