Simultaneous Determination of Propranolol Hydrochloride and Sodium Benzoate in Oral Liquid Preparations by HPLC

Zahálka, Lukáš; Matysová, Ludmila; Šklubalová, Zdeňka; Klovrzová, Sylva; Solich, Petr

doi:10.1007/s10337-013-2457-z

Cited by 13 publications

(11 citation statements)

References 7 publications

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“…The precision, estimated as percent relative standard deviation (% RSD) of ten consecutive DPV experiments of test solution containing 10 μM of each analyte ranged between 5 % and 6 %. The LODs obtained in this study, although encouraging and appropriate for routine applications, are generally higher than those specified in other studies based on the spectrophotometric or mass spectrometry procedures 8–13, 33–36. On the other hand, DPV techniques based on the chemically modified electrodes show LODs equal or less than 0.5 μM 21–28.…”

Section: Resultscontrasting

confidence: 41%

“…Numerous analytical methods proposed for the determination of the common β‐blockers in various contexts are mainly based on reverse‐phase liquid chromatography generally coupled with spectrophotometric UV‐Vis detection, fluorescence or mass spectrometry devices used as on‐line detectors 8–13. Other analytical methodologies based on chemiluminescence measurements 14, diffuse reflectance spectroscopy 15 or near‐infrared spectrometry 16, have also been developed.…”

Section: Introductionmentioning

confidence: 99%

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Determination of some β‐Blockers by Electrochemical Detection on Polycrstalline Gold Electrode after Solid Phase Extraction (SPE)

2015

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Dedicated to professor Pier Giorgio Zambonin on the occasion of his 80th birthday. 1Introductionb-blockers,a lso called b-adrenergic antagonists such as: propranolol( Pp), atenolol( At), nadolol (Nd), bisoprolol, etc. are of therapeutic interest in the treatment of various cardiovasculard isorders,a ngina pectoris,c ardiaca rrhythmia, hypertension and associated pathologies,e tc. [1][2][3]. Thep ropranolol, 1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol, is consideredt he prototype drug of b-adrenergic blockers.I ts main medicalu se has changed, in the last years,f rom therapyo fc ardiovascular diseases to therapy of infantile haemangiomas in pediatric patients.I nf act, Pp orally administered, has ac onsistent and rapid therapeutic effect, leadingt oc onsiderable shortening of the naturalc ourse of infantile haemangiomas with good clinical tolerance.I na ddition, this therapeutic drugc ould also be usedi ns ome sports requiringi ntensec oncentration as ad oping agent [4].I nt his respect, the International Olympic Committee has classified the Pp as doping specie and has includedi nalist of forbidden substances.Although these b-blockers are widely used in many therapeutic contexts,h igh plasma concentration of the Pp,N d, At, etc. can cause severe respiratoryp roblems such as asthma, adult respiratory distress syndromea nd heart failure [5].I np articular,a tenolol can be associated with an increasedr isk of diabetesm ellitus and increased risk of stroke [6].T hus,t hese drugs require continuous monitoring in biological fluids and/or pharmaceutical formulations for adjusting the corresponding dose in order to preventh azardouse ffects on health.Substantial amounts of these pharmaceuticals and their metabolitesg et into the wastewater after excretion and finallyi ns urface water due to an incomplete eliminationi n wastewater treatments.I nt his respect, recent ecotoxicological studies show that several aquatic organisms are sensitive to the presence of some b-blockers and/ort heir derivatives [7].Inparticular, the contact of hospital pollutantsw ith aquatic ecosystems leads to as evere risk on biological balance of natural environments.O nt he basis of these considerations,s imple,s ensitive,a ccurate and inexpensivea nalytical methodologies for quantification of thesec ompounds in biological fluids,e nvironmentalc ontextsa nd pharmaceutical formulations is required.Numerous analytical methods proposed for the determination of the common b-blockers in variousc ontexts are mainly based on reverse-phase liquid chromatography generally coupled with spectrophotometric UV-Vis detection,f luorescence or mass spectrometryd evices used as on-line detectors [8][9][10][11][12][13]. Other analyticalm ethodologies basedo nc hemiluminescence measurements [14],d iffuse Abstract:T he electroanalyticalc haracterizationa nd determinationo ft hree selected b-blocker agents,n amely propranolol, atenolol and nadolol usingc yclic voltammetry and differential pulse voltammetry (DPV) in phosphate buffer solution (pH 2.5) plus 22 %a cet...

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Section: Resultscontrasting

confidence: 41%

Section: Introductionmentioning

confidence: 99%

Determination of some β‐Blockers by Electrochemical Detection on Polycrstalline Gold Electrode after Solid Phase Extraction (SPE)

2015

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“…[20][21][22] The amount of disodium hydrogen phosphate dodecahydrate was adjusted experimentally during the preparation development. In our experience, this formulation has a more pleasant taste than the F1 formulation.…”

Section: Developed Paediatric Formulationsmentioning

confidence: 99%

Furosemide ethanol-free oral solutions for paediatric use: formulation, HPLC method and stability study

et al. 2017

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BackgroundOral liquid solutions of the diuretic active ingredient furosemide (FUR) marketed across Europe do not comply with recent requirements for paediatric preparation owing to their ethanol content and, moreover, in some countries only tablet or injection dosage forms of furosemide are available.ObjectivesTo formulate extemporaneous paediatric ethanol-free solutions of FUR (2 mg/mL) with suitable solubility in the aqueous vehicle and an acceptable taste and to evaluate their stability under two different storage conditions during a 9-month study period.MethodsOur work presents two developed formulations of FUR ethanol-free paediatric oral solutions 2 mg/mL for easy extemporaneous compounding in a pharmacy. FUR solubility avoiding the use of ethanol was achieved using sodium hydroxide (formulation F1) or disodium hydrogen phosphate dodecahydrate (formulation F2). The preparations were stored at 25°C±3°C or at 40°C±0.5°C and protected from light. For FUR and preservative, methylparaben (MP), a stability assay was conducted by a high-performance liquid chromatography validated method and determination of pH stability.ResultsThe remaining FUR concentration was >90% of the initial concentration after 270 days in both formulations at both storage conditions, 25°C and 40°C. The concentration of MP decreased significantly in the formulation F2 stored at 40°C.ConclusionsBoth formulations were stable when stored at room temperature for up to 9 months; formulation F1 was stable even at 40°C. MP used as an antimicrobial agent fully satisfied the recommended criteria for preservative efficacy in oral preparations according to the European Pharmacopoeia 9.0 (5.1.3).

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“…3 The rising demands for propranolol detection have driven tremendous efforts in the development of sensitive methods for quantification of propranolol in pharmaceutical formulations. [4][5][6][7][8] Among various analytical methods such as chromatographic and spectrophotometric analysis, electrochemical techniques have attracted considerable interest due to the high efficiency and low cost. 9,10 However, the direct oxidation of propranolol at conventional electrodes, including glassy carbon electrodes, requires high overpotentials.…”

Section: Introductionmentioning

confidence: 99%

Ion-Transfer Voltammetric Behavior of Propranolol at Nanoscale Liquid–Liquid Interface Arrays

2015

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In this work, the ion-transfer voltammetric detection of the protonated β-blocker propranolol was explored at arrays of nanoscale interfaces between two immiscible electrolyte solutions (ITIES). Silicon nitride nanoporous membranes with 400 pores in a hexagonal arrangement, with either 50 or 17 nm radius pores, were used to form regular arrays of nanoITIES. It was found that the aqueous-to-organic ion-transfer current continuously increased steadily rather than reaching a limiting current plateau after the ion-transfer wave; the slope of this limiting current region was concentration dependent and associated with the high ion flux at the nanointerfaces. Electrochemical data were examined in terms of an independent nanointerface approach and an equivalent microdisc approach, supported by finite element simulation. In comparison to the larger interface configuration (50 nm radius), the array of 17 nm radius nanoITIES exhibited a 6.5-times higher current density for propranolol detection due to the enhanced ion flux arising from the convergent diffusion to smaller electrochemical interfaces. Both nanoITIES arrays achieved the equivalent limits of detection, 0.8 μM, using cyclic voltammetry. Additionally, the effect of scan rate on the charging and faradaic currents at these nanoITIES arrays, as well as their stability over time, was investigated. The results demonstrate that arrays of nanoscale liquid-liquid interfaces can be applied to study electrochemical drug transfer, and provide the basis for the development of miniaturized and integrated detection platforms for drug analysis.

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Simultaneous Determination of Propranolol Hydrochloride and Sodium Benzoate in Oral Liquid Preparations by HPLC

Cited by 13 publications

References 7 publications

Determination of some β‐Blockers by Electrochemical Detection on Polycrstalline Gold Electrode after Solid Phase Extraction (SPE)

Determination of some β‐Blockers by Electrochemical Detection on Polycrstalline Gold Electrode after Solid Phase Extraction (SPE)

Furosemide ethanol-free oral solutions for paediatric use: formulation, HPLC method and stability study

Ion-Transfer Voltammetric Behavior of Propranolol at Nanoscale Liquid–Liquid Interface Arrays

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