Simultaneous Determination of Selected Antidiabetic Pharmaceutical Drugs as Adulterants in Herbal Medicines Sold in Kenya Using Liquid Chromatography–Tandem Mass Spectrometry (LC–MS/MS)

Maina, Caroline W.; Gachanja, Anthony; Kigondu, Elizabeth; Kairigo, Pius K.; Ouma, Josephine A.; Tuhkanen, Tuula; Gichuki, Joyline; Koech, Lilian C.; Nyangacha, Ruth

doi:10.1007/s42250-023-00665-9

Cited by 1 publication

(1 citation statement)

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“…8 A very recent research work reported a simultaneous determination of selected antidiabetic pharmaceutical drugs as adulterants in herbal medicines sold in Kenya using liquid chromatography-tandem mass spectrometry (LC-MS/MS). 9 To overcome this barrier, the University of Georgia developed a test method using the radiocarbon dating technique to analyze curcumin products on the market to determine the percentage of synthetic curcumin (SC) versus natural curcumin (NC) or a combination of both. Currently, this approach is not in use due to its high expenditure, high-skilled labor, time consumption and lack of availability.…”

Section: Current Available Analytical Techniques and Their Limitationsmentioning

confidence: 99%

Identification of Synthetic Impurities and Their Significance in Natural Products Quality Control

Nunavath,

Nagappan

2024

Natural Product Communications

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Herbal remedies are widely sought after in developing countries for primary healthcare due to their cost-effectiveness, compatibility with the human body and minimal adverse effects. According to World Health Organization, 80% of the world's population still rely on traditional medicine as their primary health care. Most of the modern drugs in the market such as aspirin, digitoxin, morphine, and quinine are derived through the scientific validation of herbal medicines.Nationally and internationally many of the pharmacopoeias and formularies had incorporated monographs for quality control of herbal species/extracts. These monograph analyses are based on herbal analytical/biological markers. Thus, these markers are gaining importance in the market as they are utilized to standardize and prove the chemical/Biological equivalence of herbal drugs. Thus, herbal drugs are adulterated with these analytical/biological markers for chemical and biological equivalence to match the regulatory requirements. Many of these herbal medicines/dietary supplements are sold in powder form, making them vulnerable to contamination with synthetic analogues. 1 Unfortunately, in today's scenario, most herbal products have not been subjected to a drug approval process to demonstrate their safety and effectiveness.Thus, there is an urge to define specific and novel analytical methods that can identify and quantify the presence of synthetic analogues in herbal medicines/dietary supplements which is evident through the literature for the analysis of herbal medicines for the presence of synthetic analogues. [2][3][4] It is essential to make a qualitative assessment and quantify the synthetic analogue's adulteration to sensitize the regulatory bodies and promote active vigilance on herbal formulations that are prone to adulteration with synthetic analogues. Letter to the Editor

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Section: Current Available Analytical Techniques and Their Limitationsmentioning

confidence: 99%

Identification of Synthetic Impurities and Their Significance in Natural Products Quality Control

Nunavath,

Nagappan

2024

Natural Product Communications

View full text Add to dashboard Cite

show abstract

Simultaneous Determination of Selected Antidiabetic Pharmaceutical Drugs as Adulterants in Herbal Medicines Sold in Kenya Using Liquid Chromatography–Tandem Mass Spectrometry (LC–MS/MS)

Cited by 1 publication

References 43 publications

Identification of Synthetic Impurities and Their Significance in Natural Products Quality Control

Identification of Synthetic Impurities and Their Significance in Natural Products Quality Control

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