Simultaneous determination of six constituents in the fruit of <i>Acanthopanax sessiliflorus</i> (Rupr. et Maxim.) Seem. by HPLC–UV

Zhao, Longshan; An, Qi; Qin, Feng; Xiong, Zhili

doi:10.1080/14786419.2013.877904

Cited by 13 publications

(8 citation statements)

References 4 publications

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“…Acanthopanax sessiliflorus belongs to the family Araliaceae and is widely distributed in Korea, China, and Japan [ 11 ]. The fruit of A. sessiliflorus has been used as a traditional medicine for hypertension, dizziness, and menopausal women’s syndrome [ 12 ], and numerous biological activities have been reported: anti-inflammatory [ 13 ], antihypertensive [ 14 ], antitumor, and immunostimulating activities [ 15 ]. A. sessiliflorus fruit can not only be eaten as a medicinal material but also used as a raw material for wine or tea, and it has been registered as a food by the Ministry of Food and Drug Safety [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

NMR-Based Metabolomics Approach to Investigate the Effects of Fruits of Acanthopanax sessiliflorus in a High-Fat Diet Induced Mouse Model

et al. 2021

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The prevalence of obesity is rapidly increasing and is recognized as a serious health problem. To investigate metabolic changes in an obese model after administration of Acanthopanax sessiliflorus, mice were divided into four groups: normal diet, high-fat diet (HFD), HFD with treatment fenofibrate, and A. sessiliflorus fruit extract. The liver tissue of mice was analyzed using nuclear magnetic resonance (NMR) spectrometry-based metabolomics. In multivariate statistical analyses, the HFD group was discriminated from the normal diet group, and the group fed A. sessiliflorus fruit was discriminated from the HFD group. In biomarker analysis between the HFD group and the group fed A. sessiliflorus fruit, alanine, inosine, formate, pyroglutamate, taurine, and tyrosine, with AUC values of 0.7 or more, were found. The levels of these metabolites were distinguished from the HFD mouse model. Changes in these metabolites were confirmed to act on metabolic pathways related to antioxidant activity.

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Section: Introductionmentioning

confidence: 99%

NMR-Based Metabolomics Approach to Investigate the Effects of Fruits of Acanthopanax sessiliflorus in a High-Fat Diet Induced Mouse Model

et al. 2021

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“…Acanthopanax senticosus Harms (ASH) and Acanthopanax sessiliflorus Seem (ASS) both belong to this genus, often called Ciwujia and Duangengwujia in China, respectively [ 3 ]. Various bioactive ingredients, i.e., triterperoid, saponins, lignans, flavones and phenolic compounds, exist in all parts of ASH and ASS plants [ 4 , 5 , 6 ]. Among them, elutheroside B is the main effect compound, which has immunomodulatary, antioxidant and anti-inflammatory activities [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

A Comparative Metabolomics Analysis Reveals the Tissue-Specific Phenolic Profiling in Two Acanthopanax Species

Liu

et al. 2018

Molecules

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Acanthopanax senticosus (Rupr. Maxim.) Harms (ASH) and Acanthopanax sessiliflorus (Rupr. Maxim.) Seem (ASS), are members of the Araliaceae family, and both are used in Asian countries. These herbals have drawn much attention in recent years due to their strong biological activity, with innocuity and little side effects. However, the common and distinct mode of compound profiles between ASH and ASS is still unclear. In this study, a high performance liquid chromatograph-mass spectrometry (HPLC-MS) method was developed to simultaneously quantify the seven major active compounds, including protocatechuate, eleutheroside B, eleutheroside E, isofraxidin, hyperoside, kaempferol and oleanolic acid. Then the targeted metabolomics were conducted to identify 19 phenolic compounds, with tight relation to the above mentioned active compounds, including nine C6C3C6-type, six C6C3-type and four C6C1-type in the two Acanthopanax species studied here. The results showed that the seven active compounds presented a similar trend of changes in different tissues, with more abundant accumulation in roots and stems for both plants. From the view of plant species, the ASH plants possess higher abundance of compounds, especially in the tissues of roots and stems. For phenolics, the 19 phenols detected here could be clearly grouped into five main clusters based on their tissue-specific accumulation patterns. Roots are the tissue for the most abundance of their accumulations. C6C3C6-type compounds are the most widely existing type in both plants. In conclusion, the tissue- and species-specificity in accumulation of seven active compounds and phenolics were revealed in two Acanthopanax species.

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“…Considering that TCMs usually contain one or more substances, multi-ingredient methods for assessing the quality of TCMs are important in order to meet the clinical requirements of safety and efficacy. Some common methods of quality control of TCMs include High-Performance Liquid Chromatography (HPLC) [1]–[3], Ultra-High Performance Liquid Chromatography (UPLC) [4], Gas Chromatography-Mass Spectrometry (GC-MS) [5], HPLC-MS [6] and UPLC-MS [7]. These methods are limited in the determination of the chemical contents of TCMs and they fail to reflect the comprehensive pharmacological effect.…”

Section: Introductionmentioning

confidence: 99%

The Activity-Integrated Method for Quality Assessment of Reduning Injection by On-Line DPPH-CE-DAD

et al. 2014

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A sensitive on-line DPPH-CE-DAD method was developed and validated for both screening and determining the concentration of seven antioxidants of Reduning injection. The pH and concentrations of buffer solution, SDS, β-CD and organic modifier were studied for the detection of DPPH and seven antioxidants. By on-line mixing DPPH and sample solution, a DPPH-CE method for testing the antioxidant activity of the complex matrix was successfully established and used to screen the antioxidant components of Reduning injection. Then, antioxidant components including caffeic acid, isochlorogenic acid A, isochlorogenic acid B, isochlorogenic acid C, chlorogenic acid, neochlorogenic acid and cryptochlorogenic acid were quantified by the newly established CE–DAD method. Finally, the total antioxidant activity and the multiple active components were selected as markers to evaluate the quality of Reduning injection. The results demonstrated that the on-line DPPH-CE-DAD method was reagent-saving, rapid and feasible for on-line simultaneous determination of total pharmacological activity and contents of multi-components samples. It was also a powerful method for evaluating the quality control and mechanism of action of TCM injection.

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Simultaneous determination of six constituents in the fruit of Acanthopanax sessiliflorus (Rupr. et Maxim.) Seem. by HPLC–UV

Cited by 13 publications

References 4 publications

NMR-Based Metabolomics Approach to Investigate the Effects of Fruits of Acanthopanax sessiliflorus in a High-Fat Diet Induced Mouse Model

NMR-Based Metabolomics Approach to Investigate the Effects of Fruits of Acanthopanax sessiliflorus in a High-Fat Diet Induced Mouse Model

A Comparative Metabolomics Analysis Reveals the Tissue-Specific Phenolic Profiling in Two Acanthopanax Species

The Activity-Integrated Method for Quality Assessment of Reduning Injection by On-Line DPPH-CE-DAD

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