Simultaneous determination of strontium ranelate and aspartame in pharmaceutical formulation for the treatment of postmenopausal osteoporosis by capillary zone electrophoresis

Carvalho, Renata Corrêa de; Netto, Annibal Duarte Pereira; Marques, Flávia Ferreira de Carvalho

doi:10.1016/j.microc.2014.06.024

Cited by 15 publications

(8 citation statements)

References 20 publications

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“…The concentrations of aspartame in Coke Zero, Sprite Zero, mango juice, kiwi fruit juice, strawberry juice and Lipton lipya tea sachet were calculated using the calibration graph to be approximately 35.36 µM, 40.20 µM, 0.96 mM, 1.34 mM, 0.88 mM, and 1.53 mM, respectively in this way. Compared with any other method presented in the literatures (Table 1) [28,60,61,62,63,64,65,66,67,68], this approach offers significantly low RSD and can expand the detection of the aspartame in real samples. Consequently, the developed MWCNTs@ZnO/PMAEFc/GCE modified electrode sensors are proved to be an effective tool for quick and simple detection of aspartame contents in real beverage or food samples.…”

Section: Resultsmentioning

confidence: 98%

“…These LOD values signify that an effective combination of the three constituents can significantly lower the LOD value of the modified electrodes, and thus detect an extremely trace amount of additives in food or beverage. These values are superior to those obtained from any other technique such as flow injection analysis (FIA), surface-bound molecular imprinting technology (SMIT), capillary zone electrophoresis (CZE), square-wave voltammetry (SWV), FTIR, DPV, hydrophilic interaction liquid chromatography (HILIC), and UV visible simultaneous analysis (CZE-UV) [10,28,59,60,61,62,63,64,65,66,67,68], and also lower than the result only obtained from MWCNTs@ZnO modified electrode sensors [28], as summarized in Table 1. This may be ascribed to unique redox electrochemical properties and fast electron transfer feature of ferrocene groups at the electrode interfaces based on a synergetic effect of these constituents [29,30].…”

Section: Resultsmentioning

confidence: 99%

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Organic–Inorganic Nanohybrid Electrochemical Sensors from Multi-Walled Carbon Nanotubes Decorated with Zinc Oxide Nanoparticles and In-Situ Wrapped with Poly(2-methacryloyloxyethyl ferrocenecarboxylate) for Detection of the Content of Food Additives

Cui

et al. 2019

Nanomaterials

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An electrochemical sensor for detection of the content of aspartame was developed by modifying a glassy carbon electrode (GCE) with multi-walled carbon nanotubes decorated with zinc oxide nanoparticles and in-situ wrapped with poly(2-methacryloyloxyethyl ferrocenecarboxylate) (MWCNTs@ZnO/PMAEFc). MWCNTs@ZnO/PMAEFc nanohybrids were prepared through reaction of zinc acetate dihydrate with LiOH·H2O, followed by reversible addition-fragmentation chain transfer polymerization of 2-methacryloyloxyethyl ferrocenecarboxylate, and were characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), Raman, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), atomic force microscope (AFM), scanning electron microscope (SEM), and transmission electron microscope (TEM) techniques. The electrochemical properties of the prepared nanohybrids with various composition ratios were examined by cyclic voltammetry (CV), and the trace additives in food and/or beverage was detected by using differential pulse voltammetry (DPV). The experimental results indicated that the prepared nanohybrids for fabrication of electrochemical modified electrodes possess active electroresponse, marked redox current, and good electrochemical reversibility, which could be mediated by changing the system formulations. The nanohybrid modified electrode sensors had a good peak current linear dependence on the analyte concentration with a wide detection range and a limit of detection as low as about 1.35 × 10−9 mol L−1, and the amount of aspartame was measured to be 35.36 and 40.20 µM in Coke zero, and Sprite zero, respectively. Therefore, the developed nanohybrids can potentially be used to fabricate novel electrochemical sensors for applications in the detection of beverage and food safety.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Organic–Inorganic Nanohybrid Electrochemical Sensors from Multi-Walled Carbon Nanotubes Decorated with Zinc Oxide Nanoparticles and In-Situ Wrapped with Poly(2-methacryloyloxyethyl ferrocenecarboxylate) for Detection of the Content of Food Additives

Cui

et al. 2019

Nanomaterials

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“…BÉLA KOVÁCS 1,2 * LAJOS KRISTÓF KÁNTOR 1 MIRCEA DUMITRU CROITORU 3 ÉVA KATALIN KELEMEN 1 MONA OBREJA 1 ELŐD ERNŐ NAGY 2 BLANKA SZÉKELY-SZENTMIKLÓSI 4 ÁRPÁD GYÉRESI 4 Literature data of the active substance revealed that only a few analytical methods have been developed for the assay of strontium ranelate, including HPLC (3)(4)(5), HPTCL (6), UV spectrophotometry (7,8), capillary electrophoresis (9) and others (10,11).…”

mentioning

confidence: 99%

Reversed phase HPLC for strontium ranelate: Method development and validation applying experimental design

et al. 2018

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A reverse-phase HPLC (RP-HPLC) method was developed for strontium ranelate using a full factorial, screening experimental design. The analytical procedure was validated according to international guidelines for linearity, selectivity, sensitivity, accuracy and precision. A separate experimental design was used to demonstrate the robustness of the method. Strontium ranelate was eluted at 4.4 minutes and showed no interference with the excipients used in the formulation, at 321 nm. The method is linear in the range of 20-320 μg mL-1 (R2 = 0.99998). Recovery, tested in the range of 40-120 μg mL-1, was found to be 96.1-102.1 %. Intra-day and intermediate precision RSDs ranged from 1.0-1.4 and 1.2-1.4 %, resp. The limit of detection and limit of quantitation were 0.06 and 0.20 μg mL-1, resp. The proposed technique is fast, cost-effective, reliable and reproducible, and is proposed for the routine analysis of strontium ranelate.

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“…The artificial sweetener sodium saccharin was found in 38.3 % of samples. Aspartame, cyclamate, acesulfame-K, and saccharin were determined in food products and pharmaceutical samples by CZE [84,85] and diet supplements [86]. The liquid samples were appropriately diluted with water and the solid samples were weighed, solubilized, and diluted appropriately in water.…”

Section: Isolation and Preconcentration Of Swts From Pharmaceuticalsmentioning

confidence: 99%

Analytical Strategies to Determine Artificial Sweeteners by Liquid Chromatography-Mass Spectrometry

Ferreira¹,

Yusty²,

Díaz³

2016

Reference Series in Phytochemistry

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The interest of consumers and government organizations on improving the quality of food and its impact on human health is growing in recent years. Consuming low-calorie foodstuffs are increasingly demanded, and the presence of artificial sweeteners plays an important role not only in food but also in waste reaching the environment. Analysis of these compounds is important in assessing food safety and quality. This chapter reviews the analytical approaches for the extraction and reliable identification and quantification of most commonly used artificial sweeteners in food, pharmaceutical, and environmental related matrices. The advantages and disadvantages of determination techniques used are described, with special emphasis on liquid chromatography coupled to mass

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Simultaneous determination of strontium ranelate and aspartame in pharmaceutical formulation for the treatment of postmenopausal osteoporosis by capillary zone electrophoresis

Cited by 15 publications

References 20 publications

Organic–Inorganic Nanohybrid Electrochemical Sensors from Multi-Walled Carbon Nanotubes Decorated with Zinc Oxide Nanoparticles and In-Situ Wrapped with Poly(2-methacryloyloxyethyl ferrocenecarboxylate) for Detection of the Content of Food Additives

Organic–Inorganic Nanohybrid Electrochemical Sensors from Multi-Walled Carbon Nanotubes Decorated with Zinc Oxide Nanoparticles and In-Situ Wrapped with Poly(2-methacryloyloxyethyl ferrocenecarboxylate) for Detection of the Content of Food Additives

Reversed phase HPLC for strontium ranelate: Method development and validation applying experimental design

Analytical Strategies to Determine Artificial Sweeteners by Liquid Chromatography-Mass Spectrometry

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