Simultaneous determination of three residual barbiturates in pork using accelerated solvent extraction and gas chromatography–mass spectrometry

Zhao, Hang; Wang, Liping; Qiu, Yueming; Zhou, Zhiqiang; Li, Xiang; Zhong, Weike

doi:10.1016/j.jchromb.2006.05.002

Cited by 34 publications

(13 citation statements)

References 13 publications

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“…In addition, as extraction pressure was fixed in Dionex ASE 300 TM instrument and 1500 psi was found as the optimal extraction pressure in published references [27,28], we did not evaluate the effect of this parameter in this study.…”

Section: Effect Of Extraction Cyclesmentioning

confidence: 99%

Pressurized liquid extraction followed by LC‐ESI/MS for analysis of four chromones in Radix Saposhnikoviae

Wang

Chen

et al. 2010

J of Separation Science

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An efficient pressurized liquid extraction (PLE) technique was employed in extracting chromones from the roots of Saposhnikovia divaricata (Radix Saposhnikoviae). Chromones were quantified and analyzed by LC-ESI/MS. The PLE procedure was optimized, validated and compared with the other conventional extraction techniques. PLE gained the best result due to the highest extraction efficiency within the shortest extraction time. The optimal conditions of PLE were employing 50% ethanol as the extraction solvent at a temperature of 140°C and an extraction pressure of 1500 psi, using one extraction cycle with a static extraction time of 8 min. A good LC separation was achieved using a Hypersil ODS2 column and methanol/water as the mobile phase at a flow rate of 0.8 mL/min. MS coupling with an ESI interface in the positive ion mode was used as the detection technique. This is the first report on combining PLE with LC-ESI/MS for the extraction and quantification of chromones in Radix Saposhnikoviae. The elaborated PLE method also provided a good alternative for the chromone extraction from other plant substances.

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Section: Effect Of Extraction Cyclesmentioning

confidence: 99%

Pressurized liquid extraction followed by LC‐ESI/MS for analysis of four chromones in Radix Saposhnikoviae

Wang

Chen

et al. 2010

J of Separation Science

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“…[31][32][33] In a recent study, Zhao et al 34 developed a new method for the extraction of barbital, amobarbital and phenobarbital residues in pork. They used a C18 SPE cartridge for clean-up the extracts after an accelerated solvent extraction of the samples.…”

mentioning

confidence: 99%

Molecularly imprinted sol-gel silica for solid phase extraction of phenobarbital

Pilau¹,

Silva²,

Jardim³

et al. 2008

J. Braz. Chem. Soc.

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Sílica organicamente modificada e molecularmente impressa foi preparada através de um procedimento sol-gel simples, e avaliada como sorvente específico para extração em fase sólida (Solid Phase Extraction, SPE) de fenobarbital em amostras aquosas e forenses. As propriedades analíticas dessa sílica molecularmente impressa (MIS, molecularly imprinted silica) foram inicialmente avaliadas e o material determinado como específico para as espécies-alvo: o fator de impressão IF, medido como a razão entre o pico do fenobarbital em cromatogramas de MIS e NIS (sílica não-impressa) foi estimado como 58. Este valor é consideravelmente maior que aquele apresentado normalmente para sorventes de impressão convencional baseados em metacrilatos e sugere que interações não-específicas analito/sorvente são insignificantes no MIS. O material foi aplicado no isolamento de fenobarbital de amostras aquosas e plasma; limites de detecção de 10 e 62 µg mL -1 , respectivamente, foram encontrados para essas amostras.A molecularly imprinted organically modified silica was prepared through a simple sol-gel procedure, and evaluated as specific sorbent for solid-phase extraction (SPE) of phenobarbital from aqueous and forensic samples. The analytical properties of the molecularly imprinted silica (MIS, non-imprinted sílica) were initially evaluated and the MIS was found to be specific towards the target species: the imprinting factor IF, measured as the ratio between phenobarbital peak areas in the MIS and NIS chromatograms, was estimated as 58. This value is considerably higher than those usually found for conventional methacrylate-based molecularly imprinted sorbents and suggests that non-specific analyte/sorbent interactions are insignificant in the MIS. This material is applied to the isolation of phenobarbital from aqueous samples and plasma; detection limit of 10 and 62 µg mL -1 was achieved for the former samples, respectively. Keywords: molecularly imprinted silica, sol-gel, ormosils, phenobarbital, SPE IntroductionThere is a demand for sensitive, accurate and simple analytical procedures. One of the tools to achieve these goals is the incorporation of biomolecules and biologicallike processes in the methodologies. However, despite of the specificity achieved on these procedures, natural biomolecules usually are expensive and chemically unstable. Synthetic materials such as molecularly imprinted polymers (MIP) are valid alternatives to these biological matrices. Molecular imprinting was proposed by Pauling 1 as a possible mechanism for the production of antibodies by living systems. According to his model, the synthesis of antibodies was based on the use of the aggressor chemical molecules as templates. Weak intermolecular forces such as hydrogen bonding or van der Waals forces drove proper monomer units to organize themselves around the antigen. Polymerization of the organized monomers and removal of the template would render macromolecules with cavities where the template or other species with similar structure could be highly select...

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“…For instance, it can be used to detect the extracts from the water, soil, sediment, minerals, chemical products, biological samples (vegetables, fruits, meat, fish, plants) and other harmful substances (such as various pesticides, hydrocarbons, chemicals and the like) [82][83][84][85][86][87][88][89][90][91][92][93] . ASE technology is very important and helpful for environmental protection and human health.…”

Section: Discussionmentioning

confidence: 99%

Optimalization of Extraction Conditions for Increasing Microalgal Lipid Yield by Using Accelerated Solvent Extraction Method (ASE) Based on the Orthogonal Array Design

Rulong¹,

Wenxuan²,

Xing³

et al. 2012

Energy Conservation

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Simultaneous determination of three residual barbiturates in pork using accelerated solvent extraction and gas chromatography–mass spectrometry

Cited by 34 publications

References 13 publications

Pressurized liquid extraction followed by LC‐ESI/MS for analysis of four chromones in Radix Saposhnikoviae

Pressurized liquid extraction followed by LC‐ESI/MS for analysis of four chromones in Radix Saposhnikoviae

Molecularly imprinted sol-gel silica for solid phase extraction of phenobarbital

Optimalization of Extraction Conditions for Increasing Microalgal Lipid Yield by Using Accelerated Solvent Extraction Method (ASE) Based on the Orthogonal Array Design

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