Simultaneous determination of two Amadori compounds in Korean red ginseng (Panax ginseng) extracts and rat plasma by high-performance anion-exchange chromatography with pulsed amperometric detection

Joo, Kyung Mi; Park, Chan-Woong; Jeong, Hye-­Jin; Lee, Sang Jun; Chang, Ih-Seop

doi:10.1016/j.jchromb.2008.02.012

Cited by 42 publications

(26 citation statements)

References 33 publications

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“…Another specific compound of RG, such as AFG and maltol was dramatically increased during the processing time as reported [23], [28]. These phenomena were also confirmed visually in step-by-step chromatograms (Fig.…”

Section: Resultssupporting

confidence: 79%

In situ analysis of chemical components induced by steaming between fresh ginseng, steamed ginseng, and red ginseng

Ahn

Bae

et al. 2017

Journal of Ginseng Research

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BackgroundThe chemical constituents of Panax ginseng are changed by processing methods such as steaming or sun drying. In the present study, the chemical change of Panax ginseng induced by steaming was monitored in situ.MethodsSamples were separated from the same ginseng root by incision during the steaming process, for in situ monitoring. Sampling was sequentially performed in three stages; FG (fresh ginseng) → SG (steamed ginseng) → RG (red ginseng) and 60 samples were prepared and freeze dried. The samples were then analyzed to determine 43 constituents among three stages of P. ginseng.ResultsThe results showed that six malonyl-ginsenoside (Rg1, Rb1, Rb3, Rc, Rd, Rb2) and 15 amino acids were decreased in concentration during the steaming process. In contrast, ginsenoside-Rh1, 20(S)-Rg2, 20(S, R)-Rg3 and Maillard reaction product such as AF (arginine-fructose), AFG (arginine-fructose-glucose), and maltol were newly generated or their concentrations were increased.ConclusionThis study elucidates the dynamic changes in the chemical components of P. ginseng when the steaming process was induced. These results are thought to be helpful for quality control and standardization of herbal drugs using P. ginseng and they also provide a scientific basis for pharmacological research of processed ginseng (Red ginseng).

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Section: Resultssupporting

confidence: 79%

In situ analysis of chemical components induced by steaming between fresh ginseng, steamed ginseng, and red ginseng

Ahn

Bae

et al. 2017

Journal of Ginseng Research

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“…Instrumental analysis of amino acids is accomplished using post-column cationic exchange HPLC, pre-column derivation HPLC (Heinrikson & Meredith, 1984), and anion-exchange chromatography methods (Thiele, Ganzle, & Vogel, 2002). High-performance anion-exchange chromatography was used for the simultaneous identification and quantification of AF and AFG (Joo, Park, Jeong, Lee, & Chang, 2008). In the present study, AF and AFG from P. quinquefolius L. were identified, isolated and then analysed using the pre-column derivation HPLC method.…”

Section: Introductionmentioning

confidence: 99%

Detection and distribution of arginine derivatives in Panax quinquefolius L. and investigations of their antioxidant properties

Gao

Zhang

Liu

et al. 2012

LWT

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“…Amino acid derivatives such as AF and AFG are widely distributed in KRG [5–7]. Previous studies reported that commercial red ginseng products could have AF and AFG levels ranging from 0.35 − 2.51 % and 0.25 − 2.64 %, respectively [8, 9]. The ginsenosides, which are better-known KRG components, have a content ranging from 0.5 − 1.1 % [8, 10].…”

Section: Introductionmentioning

confidence: 99%

Antihyperglycemic effect of short-term arginyl-fructose supplementation in subjects with prediabetes and newly diagnosed type 2 diabetes: randomized, double-blinded, placebo-controlled trial

Park

Kim

Kwak

et al. 2015

Trials

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BackgroundA previous study reported that arginyl-fructose may have great value as a functional food with antioxidant and antidiabetic activities. However, there have been few clinical studies on the efficacy of arginyl-fructose supplementation for blood glucose control.MethodsIn this double-blind, placebo-controlled study, 60 Korean subjects with prediabetes or type 2 diabetes mellitus were randomly assigned to placebo or test groups. The test group subjects received 1500 mg/day arginyl-fructose. Fasting serum levels of glucose, hemoglobin A1c, insulin, and free fatty acids were measured by 2-hour oral glucose tolerance tests at baseline and after the 6-week intervention. Eleven subjects dropped out or were excluded during the trial. The data for the remaining 49 were statistically analyzed using Student’s t-test and paired t-test.ResultsAfter the 6-week intervention, the test group showed significant reductions in serum glucose levels at 30 minutes (−19.4 ± 5.62 mg/dL) and 60 minutes (−15.4 ± 7.01 mg/dL) and reduced glucose area under the curve (−27.4 ± 8.59 mg/dL) compared with those of the placebo control group. The changes (differences from baseline) in serum glucose levels at 60 minutes and glucose area under the curve in the test group differed significantly from those in the control group even after adjusting for baseline values. In contrast, glucose-related biomarkers including hemoglobin A1c, insulin, and C-peptide levels were not significantly improved by the dietary intervention with arginyl-fructose.ConclusionsArginyl-fructose supplementation (1500 mg/day) may be beneficial for reducing postprandial blood glucose levels in patients with prediabetes or type 2 diabetes mellitus.Trial registrationClinicalTrials.gov NCT02285231. Registered 11 May 2014.Electronic supplementary materialThe online version of this article (doi:10.1186/s13063-015-1036-z) contains supplementary material, which is available to authorized users.

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Simultaneous determination of two Amadori compounds in Korean red ginseng (Panax ginseng) extracts and rat plasma by high-performance anion-exchange chromatography with pulsed amperometric detection

Cited by 42 publications

References 33 publications

In situ analysis of chemical components induced by steaming between fresh ginseng, steamed ginseng, and red ginseng

In situ analysis of chemical components induced by steaming between fresh ginseng, steamed ginseng, and red ginseng

Detection and distribution of arginine derivatives in Panax quinquefolius L. and investigations of their antioxidant properties

Antihyperglycemic effect of short-term arginyl-fructose supplementation in subjects with prediabetes and newly diagnosed type 2 diabetes: randomized, double-blinded, placebo-controlled trial

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