Simultaneous determination of uric acid, xanthine and hypoxanthine with an electrochemically pretreated carbon paste electrode

Cai, Xiaohua; Kalcher, Kurt; Neuhold, Christian

doi:10.1007/bf00325569

Cited by 34 publications

(27 citation statements)

References 23 publications

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“…Early work measured the voltammetric oxidation of UA, XA and HX at a glassy carbon electrode, but this procedure suffered from serious interference by ascorbic acid and also there was a nonlinear dependence of the current response on the concentration of these compounds [47]. Other workers proposed a method which utilised simultaneous differential pulse voltammetric determination of the three compounds at an electrochemically pre-treated carbon paste electrode [48]. A preanodised nontronite (an iron-rich clay) coated screenprinted carbon electrode could be used for the simultaneous determination of HX, XA and UA [49], with detection limits of 0.34, 0.07 and 0.42 mmol L…”

Section: Direct Electrochemical Detection Of Uric Acidmentioning

confidence: 98%

“…Various reports have been published for the simultaneous determination of UA in the presence of other species such as AA, dopamine, xanthine (XA) and hypoxanthine (HX), by nonenzymatic electrochemical approaches [35,36,[47][48][49][50][51][52][53][54]. Early work measured the voltammetric oxidation of UA, XA and HX at a glassy carbon electrode, but this procedure suffered from serious interference by ascorbic acid and also there was a nonlinear dependence of the current response on the concentration of these compounds [47].…”

Section: Direct Electrochemical Detection Of Uric Acidmentioning

confidence: 99%

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Electrochemical Detection of Uric Acid in Mixed and Clinical Samples: A Review

et al. 2011

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The present review has sought to explore the technological advances that have been made in recent years towards the selective analysis of uric acid and critically evaluate how they could, in fact, be exploited as a basis for a multi analyte sensor incorporating uric acid detection. Numerous strategies have evolved in recent years but these have invariably focused on the manufacture and response characterization of discrete sensors. Various methods of obtaining selective detection such as use of uricase enzymes, nanoparticles, carbon nanotubes, polymers, conducting polymers and MIPs are also discussed along with the clinical relevance of UA determination.

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Section: Direct Electrochemical Detection Of Uric Acidmentioning

confidence: 98%

Section: Direct Electrochemical Detection Of Uric Acidmentioning

confidence: 99%

Electrochemical Detection of Uric Acid in Mixed and Clinical Samples: A Review

et al. 2011

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“…Sensors have been developed using microelectrodes [8], chemically modified electrodes [9,10] and by mechanical or electrochemical activation of the electrode surfaces [11,12]. However, most of the reported research has used oxidase-based enzyme biosensors for hypoxanthine detection with measurement of oxygen consumption or product formation [13 -25].…”

Section: Introductionmentioning

confidence: 99%

Voltammetric and impedance studies of inosine-5′-monophosphate and hypoxanthine

Oliveira-Brett

Silva

Farace

et al. 2003

Bioelectrochemistry

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The oxidation mechanism and adsorption of inosine 5V -monophosphate and hypoxanthine were investigated in solutions of different pH using voltammetric and impedance methods at glassy carbon electrodes. For both compounds, the pH dependence from differential pulse voltammetry showed that the same number of electrons and protons are involved in the rate-determining step of the electrochemical reaction. In the case of hypoxanthine, it was also possible to study the effect of different concentrations. At high concentrations of hypoxanthine, two oxidation peaks were observed, the first due to hypoxanthine oxidation with formation of oligomers and the second due to hypoxanthine oligomer oxidation, both compounds adsorbing strongly. Impedance measurements corroborated the voltammetric results and enabled the study of the adsorption of hypoxanthine on glassy carbon. D

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“…The electro-oxidation of urate at various forms of carbon is well documented and there are numerous analytical methodologies incorporating such [19][20][21][22][23][24]. The uses of carbon fibre electrodes for biomedical applications are also well documented for the detection of: nitric oxide [25], lactate dehydrogenase [26], perphenazine [27], haemoglobin [28], ascorbate, catechol and indole [29], chloramphenicol [30] and uric acid [31,32] However the aforementioned detection of uric acid was performed in-vitro, using diluted sample and a large surface area sensor.…”

Section: Nottingham Trent University August 2007mentioning

confidence: 99%

Carbon Fibre Composites: Integrated Electrochemical Sensors for Wound Management

Sharp

Forsythe

Davis

2008

The Journal of Biochemistry

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The applicability of employing a carbon fibre mesh as an electrochemical sensing substructure for assessing urate transformations within wound exudates is evaluated. Prototype sensor assemblies have been designed and their response characteristics towards uric acid and other common physiological components are detailed. Modification of the carbon fibre sensor through surface anodisation and the application of cellulose acetate permselective barriers have been shown to lead to optimized responses and much greater sensitivity (1440% increase) and specificity. These could enable the accurate periodic monitoring of uric acid in wound fluid. The performance characteristics of the composite sensors in whole blood, serum and blister fluid have been investigated. KeywordsCarbon fibre, smart bandage, urate, uric acid, wound infection 2 Sharp et al.

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Simultaneous determination of uric acid, xanthine and hypoxanthine with an electrochemically pretreated carbon paste electrode

Cited by 34 publications

References 23 publications

Electrochemical Detection of Uric Acid in Mixed and Clinical Samples: A Review

Electrochemical Detection of Uric Acid in Mixed and Clinical Samples: A Review

Voltammetric and impedance studies of inosine-5′-monophosphate and hypoxanthine

Carbon Fibre Composites: Integrated Electrochemical Sensors for Wound Management

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