Simultaneous Differential Pulse Voltammetric Determination of Ascorbic Acid and Caffeine in Pharmaceutical Formulations Using a Boron‐Doped Diamond Electrode

Abstract

A cathodically pretreated boron-doped diamond electrode was used for the simultaneous anodic determination of ascorbic acid (AA) and caffeine (CAF) by differential pulse voltammetry. Linear calibration curves (r ¼ 0.999) were obtained from 1.9 Â 10 À5 to 2.1 Â 10 À4 mol L À1 for AA and from 9.7 Â 10 À6 to 1.1 Â 10 À4 mol L À1 for CAF, with detection limits of 19 mmol L À1 and 7.0 mmol L À1, respectively. This method was successfully applied for the determination of AA and CAF in pharmaceutical formulations, with results equal to those obtained using a HPLC reference method.

Electrochemical sensor for the simultaneous determination of caffeine and aspirin in human urine samples

“…It is the most commonly used stimulant drug due to its ability to arouse the central nervous system (CNS) and cardiovascular system [10,11]. CAF is usually prescribed as analgesic adjuvant in pharmaceutical preparations for the treatment of headache and pain related to postpartum, postoperative, and dental surgery [12,13] and therapeutically used for the treatment of migraine in combination with ergotamine [14]. CAF also acts as a natural pesticide as it kills the insects that attempt to feed on plants [15] and is the main and active ingredient of coffee and plays an important role in determining the quality of coffee beverages [16].…”

Determination of ascorbic acid levels in food samples by using an ionic liquid–carbon nanotube composite electrode

“…At the traditional electrodes, DA and UA are oxidised at potentials close to that of AA, resulting in an overlapping voltammetric response (Lourenção et al, 2010;Zhu et al, 2009). Fig.…”

“…The linear equation was calibrated as I AA (lA) = 0.16 + 20.12C AA (mM) with the correlation coefficient of 0.9990 in the concentration range from 3.0 lM to 4.2 mM and the detection limit was evaluated as 1.0 lM (S/N = 3), which was much lower than boron doped diamond electrode (19.0 lM) (Lourenção, Medeiros, Rocha-Filho, & Fatibello-Filho, 2010), ordered mesoporous carbon/Nafion modified GCE (20.0 lM) (Zheng, Ye, Zhou, Zhang, & Yu, 2009), and polyacrylic acid-CNT modified screen-printed carbon electrode (49.8 lM) (Huang, Liao, & Chen, 2010). When compared with the CNT modified carbon ceramic electrode (3.0 lM) (Habibi & Pournaghi-Azar, 2010), copper nanoparticles/polyaniline modified GCE (2.0 lM) (Xi, Ren, Luo, & Zhu, 2010), and polystyrene sulfonate/CNT modified graphite electrode (0.5 lM) (Manjunatha, Suresh, Melo, D'Souza, & Venkatesha, 2010), the present electrode showed the comparable detection limit.…”

Bioelectroanalysis of pharmaceutical compounds

“…The same research group simultaneously determined ascorbic acid (2-(1,2-dihydroxyethyl)-4,5-dihydroxyfuran-3-one) (AA) and caffeine (1,3,7-trimethyl-purine-2,6-dione) (CAF) by differential pulse voltammetry (DPV) using a cathodically pre-treated boron-doped diamond electrode as working electrode [155]. Linear analytical curves (r00.999) were obtained from 1.9×10 −5 to 2.1×10 −4 M for AA and from 9.7×10 −6 to 1.1×10 −4 M for CAF, with detection limits of 19 μM and 7.0 μM, respectively.…”