Simultaneous early adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach associated with Helicobacter pylori infection

Sakai, Takehiro; Ogura, Yuta; Narita, Junichi; Suto, T; Kimura, Daisuke; Ainai, S; Fujita, Hideaki; Kamada, Mitsuru

doi:10.1007/s10120-003-0241-8

Cited by 25 publications

(15 citation statements)

References 20 publications

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“…only been considered a major pathogenic factor for chronic gastritis, peptic ulcer, gastric cancer and mucosa-associated lymphoid tissue lymphoma of the stomach, (8,9) it has also been found to be closely related to chronic liver disease. (10) First discovered in 1992, infection with H. hepaticus was shown to cause chronic active hepatitis that ultimately induced the development of hepatocellular tumours in A/JCr mice.…”

Section: Since Its Initial Identification H Pylori Infection Has Notmentioning

confidence: 99%

Helicobacter hepaticus infection in primary hepatocellular carcinoma tissue

Yang¹,

Ji²,

Zhang³

et al. 2013

smedj

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INTRODUCTION Helicobacter (H.) hepaticus infection causes chronic active hepatitis and induces hepatocellular tumours in A/JCr mice, but evidence of this in humans is scarce. This study aimed to demonstrate the correlation between H. hepaticus and human primary hepatocellular carcinoma (HCC). MeThODsThe sera of 50 patients with primary HCC were tested for the presence of anti-H. pylori and anti-H. hepaticus immunoglobulin G (IgG) antibodies. The liver tissues of patients who tested positive for serum antibody were analysed for H. hepaticus-specific 16S rRNA, H. hepaticus cdtB, H. pylori cagA, H. pylori vacA and H. pylori ureC genes using polymerase chain reaction. ResUlTsAfter the anti-H. pylori antibodies in the serum samples were absorbed by H. pylori antigen, the anti-H. hepaticus IgG serum antibody detection rate was 50.0% in patients with primary HCC. This was significantly higher (p < 0.001) than the detection rate in the benign liver tumour (7.7%) and normal liver tissue (6.3%) groups. Of the 25 primary HCC samples that tested positive for anti-H. hepaticus IgG serum antibody, the H. hepaticus-specific 16S rRNA gene was detected in nine (36.0%) samples. Sequencing showed that the polymerase chain reaction-amplified product exhibited 95.5%-100% homology to the H. hepaticus-specific 16S rRNA gene. Among these nine primary HCC tissue samples, the H. hepaticus cdtB gene was detected in four (44.4%) samples, while no such expression was observed in the benign liver tumour or normal liver tissue groups. CONClUsIONThe present study identified the presence of H. hepaticus infection in patients with primary HCC using serological and molecular biological detection, suggesting that H. hepaticus infection may be involved in the progression of HCC.

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Section: Since Its Initial Identification H Pylori Infection Has Notmentioning

confidence: 99%

Helicobacter hepaticus infection in primary hepatocellular carcinoma tissue

Yang¹,

Ji²,

Zhang³

et al. 2013

smedj

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“…Cette entité est rare. Cinquante-six observations ont été rapportées par la littérature occidentale surtout anglo-saxonne dont dix ont été publiées en 1995 [4] et neuf en 1997 [1,5]. Quarante-cinq cas de tumeurs gastriques synchrones étaient décrits dans la littéra-ture japonaise [6].…”

Section: Discussionunclassified

“…Actuellement, l'H. pylori est incriminé aussi bien dans la carcinogenèse que dans la lymphomatogenèse gastrique [3,4,10]. Lorsque l'H.…”

Section: Discussionunclassified

Association d’un lymphome et d’un adénocarcinome gastrique : à propos de quatre cas

et al. 2012

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“…It is well known that both gastric adenocarcinoma and gastric MALToma are related to Helicobacter pylori infection (12 -15) and, interestingly, cases of simultaneous gastric MALT lymphoma and adenocarcinoma have been reported (16). The genetic susceptibility of the host makes the difference between the high number of patients with H. pylori infection and the small number of patients who develop gastric MALToma.…”

Section: Discussionmentioning

confidence: 99%

Risk of Second Cancer in Nongastric Marginal Zone B-Cell Lymphomas of Mucosa-Associated Lymphoid Tissue: A Population-Based Study from Northern Italy

Arcaini¹,

Burcheri²,

Rossi³

et al. 2007

Clinical Cancer Research

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Purpose: The aim of this study was to define the risk of second cancer in nongastric marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT). Experimental Design: We considered for the analysis 157 patients with a confirmed histology of marginal zone B-cell lymphoma of MALT, presenting with a clinically prevalent extranodal site of disease, except for stomach. All patients came from two hematologic institutions of Northern Italy. We compared the occurrence of second cancer with respect to the general population by calculating the standardized incidence ratio, with the age-and sex-specific incidence rates of a cancer registry of Northern Italy (Lombardia) as a reference. Results: A history of solid neoplasia was present in 29 (18%) patients for a total number of 30 neoplasms: 25 solid tumors, 2 hematologic diseases (1 Hodgkin's lymphoma and 1 essential thrombocythemia), and 3 nonmelanoma in situ skin cancers. In 4 patients, the site of cancer and lymphoma was the same. In 21cases the solid tumor preceded the MALToma, in 3 the neoplasm was concomitant, whereas in 6 it was subsequent. For the entire group, the standardized incidence ratio of an additional malignancy was 0.8 [95 % confidence interval (95 % CI), 0.55-1.17; P = 0.2]. After excluding nonmelanoma skin cancer, the standardized incidence ratio of a second tumor was 0.75 (95% CI, 0.5-1.12; P = 0.2). After excluding all previous malignancies, the standardized incidence ratio of a second cancer was 1.32 (95% CI, 0.69-2.55; P = 0.4). The comparison of risks between males and females was not significant in each group analysis. Conclusions: Patients with nongastric MALT lymphomas are not at increased risk for other neoplasms compared with the general population of the same geographic area.

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Simultaneous early adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach associated with Helicobacter pylori infection

Cited by 25 publications

References 20 publications

Helicobacter hepaticus infection in primary hepatocellular carcinoma tissue

Helicobacter hepaticus infection in primary hepatocellular carcinoma tissue

Association d’un lymphome et d’un adénocarcinome gastrique : à propos de quatre cas

Risk of Second Cancer in Nongastric Marginal Zone B-Cell Lymphomas of Mucosa-Associated Lymphoid Tissue: A Population-Based Study from Northern Italy

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