Simultaneous encapsulation of magnetic nanoparticles and zinc phthalocyanine in poly(methyl methacrylate) nanoparticles by miniemulsion polymerization and in vitro studies

Encapsulation of Magnetic Nanoparticles and Copaíba Oil in Poly(methyl methacrylate) Nanoparticles via Miniemulsion Polymerization for Biomedical Application

“…[31,32] The high colloidal stability of the system could be attributed to the presence of lecithin adsorbed at the surface of the PMMA-MNPs-CO NPs. [26,33] Figure 1 displays the TEM image of PMMA-MNPs-CO. As can be observed, the NPs presented submicrometric size with a number average diameter equal to 84 ± 3 nm as observed in Figure 2, with the particle size distribution.…”

“…[15,[22][23][24][25] Also, PMMA has desirable physicochemical properties to perform a simple and one step miniemulsion polymerization and simultaneously encapsulate different types of biomolecules and structures in the NPs. [26,27] In this way, the goal of this study was to synthesize and characterize PMMA NPs containing MNPs and CO obtained by miniemulsion polymerization. Lastly, in vitro cytotoxicity assays were performed in embryo mouse fibroblast (NIH3T3) cells.…”

Incorporation of Magnetic Nanoparticles in Poly(Methyl Methacrylate) Nanocapsules

“…For these applications, MNPs must combine properties of high magnetic saturation, super‐paramagnetic properties and biocompatibility. The encapsulation of MNPs in polymeric particles aims to protect and to prevent aggregation of MNPs and at the same time can ensure the mobility of the polymeric particles when a magnetic field is applied, enabling their use for targeted delivery of therapeutic agents in combination with hyperthermia in cancer treatments …”

“…Miniemulsion polymerization has been used to encapsulate MNPs into polymeric nanoparticles in different polymeric matrixes such as polystyrene, poly(styrene–butadiene), poly(urea–urethane), and poly(methyl methacrylate) (PMMA) . However, as far as the authors are aware, the incorporation of MNPs in polymer nanocapsules was not previously studied.…”

Bio‐Based Hybrid Magnetic Latex Particles Containing Encapsulated γ ‐Fe2O3 by Miniemulsion Copolymerization of Soybean Oil‐Acrylated Methyl Ester and Styrene

“…The scientific literature reports researches involving the use of miniemulsion polymerization for development of magnetic hybrid nanomaterials as, for instance, the encapsulation of MNPs in poly(methyl methacrylate) (PMMA) through minimemulsion as reported by Feuser et al . According to the research, the obtained nanocomposites with ≈100 nm average diameters did not present cytotoxicity, making them suitable for application in hyperthermia treatment as suggested by the authors.…”