Granular cell tumors (GCTs) are uncommon neoplasms that occur in various organs, including the integumentary system, respiratory tract, and gastrointestinal tract. Colonic granular cell tumors are rare and account for less than 0.5% of soft tissue tumors. The gross endoscopic diagnosis of colonic tumors can be challenging due to their submucosal predominance, and advanced endoscopic techniques are necessary for diagnosis and management. We present a rightsided granular cell tumor resected en bloc during colonoscopy and hypothesize that colonic granular cell tumors have a higher affinity for the right colon. The aim of this paper is to review the literature on granular cell tumors of the colon and assess the clinical and pathological characteristics, diagnosis, and management of granular cell tumors of the colon.