Simultaneous Estimation of Lansoprazole and Domperidone in Tablet Dosage Form by Rp-HPLC

Abstract

INTRODUCTIONwhich is used as specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. Lansoprazole chemically is 2-({[3-methyl-4-(2, 2, 2-trifluoroethoxy) pyridin-2-yl] methane} sulfinyl)-1H-1, 3-benzodiazole and used as a proton pump inhibitor which prevents the stomach from producing acid [1-2].Literature survey reveals that there are methods to analyse these drugs by spectroscopic methods [3][4], in tablet [5][6][7][8][9][10][11][12][13][14][15][16], in plasma [17][18].There are no methods reported in tablets using Buffer and Acetonitrile as solvent which is cost effective.Hence an attempt is made to develop simple, Accurate and Precise and cost effective method [19][20] for simultaneous estimation of Lansoprazole and Domperidone by RP-HPLC in tablet dosage form according to ICH guidelines [21].