2018
DOI: 10.1080/16583655.2018.1490562
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Simultaneous estimation of silodosin and silodosin β-D-glucuronide in human plasma using LC-MS/MS for a pharmacokinetic study

Abstract: A rapid, simple, sensitive and selective LC-MS/MS method has been developed and validated for simultaneous quantification of silodosin and silodosin β-D-glucuronide human plasma using stable labelled isotopes as internal standards. Solid phase extraction technique (SPE) was used for the extraction and the method validated over a range of 0.20 ng/mL to 100.56 ng/mL for silidisin and 0.20 ng/mL to 101.63 ng/mL for silodosin β-D-glucuronide. The chromatographic separation was achieved on Cosmicsil Adze C18 (4.6 ×… Show more

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“…SLD is a potent antagonist of post-synaptic alpha adrenoreceptors which are found mainly in the human prostate, the base of the bladder, the neck of the bladder, the urethral capsule, and the prostatic urethra [6,7]. Due to the inhibition of alpha-1 adrenoreceptor, the smooth muscles in these tissues may relax which enhances urine flow and lower the BPH symptoms [8,9]. SLD is easily soluble in methanol, ethanol, and acetic acid but very slightly soluble in water.…”
Section: Introductionmentioning
confidence: 99%
“…SLD is a potent antagonist of post-synaptic alpha adrenoreceptors which are found mainly in the human prostate, the base of the bladder, the neck of the bladder, the urethral capsule, and the prostatic urethra [6,7]. Due to the inhibition of alpha-1 adrenoreceptor, the smooth muscles in these tissues may relax which enhances urine flow and lower the BPH symptoms [8,9]. SLD is easily soluble in methanol, ethanol, and acetic acid but very slightly soluble in water.…”
Section: Introductionmentioning
confidence: 99%