Simultaneous estimation of valdecoxib and tizanidine hydrochloride in tablets by RP-HPLC

Puranik, Manisha; Wadher, S. J.; Dhole, Seema M.; Yeole, PG

doi:10.4103/0250-474x.29647

Cited by 6 publications

(1 citation statement)

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“…United States Pharmacopeia (USP) have analytical methodologies involving TZ, using high performance liquid chromatography (LC) for related compounds determination (USP 39, 2016). Studies using LC have been reported with tizanidine alone or in association with other drugs, but there isn`t one using association with charged aerosol detector (CAD) (2,(5)(6)(7)(8). CAD detector is a new type of detector introduced for LC applications.…”

Section: Introductionmentioning

confidence: 99%

Stability-Indicating Method for Determination of Tizanidine Hydrochloride in Pharmaceutical Lc-Cad Method Using Chemometric Approach

et al. 2017

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A new LC method for tizanidine hydrochloride in tablet dosage form using a charged aerosol detector (CAD) is described. The influence of various parameters on chromatographic system was investigated by factorial designs and Derringer's desirability. Chromatographic conditions were: mobile phase constituted of acetonitrile and ammonium acetate buffer 17 mM (60:40; v/v), column oven at 39 °C and flow rate 0.8 mL.min-1 performed in on Acclaim Trinity P1 column UV at 230 nm. Thus, it was possible to validate a simple method to assay the tizanidine and its counter-ion in three formulations (drug reference, generic and manipulated). Method showed specificity when challenged by forced degradation and excipients. Finally, the method was compared with USP monograph method demonstrating equivalence in assay evaluation.

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Section: Introductionmentioning

confidence: 99%

Stability-Indicating Method for Determination of Tizanidine Hydrochloride in Pharmaceutical Lc-Cad Method Using Chemometric Approach

et al. 2017

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Sensitive spectrofluorimetric determination of tizanidine in pharmaceutical preparations, human plasma and urine through derivatization with dansyl chloride

Ulu

2011

Luminescence

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A sensitive spectrofluorimetric method was developed for the determination of tizanidine in human plasma, urine and pharmaceutical preparations. The method is based on reaction of tizanidine with 1-dimethylaminonaphthalene-5-sulphonyl chloride (dansyl chloride) in an alkaline medium to form a highly fluorescent derivative that was measured at 511 nm after excitation at 383 nm. The different experimental parameters affecting the fluorescence intensity of tizanidine was carefully studied and optimized. The fluorescence-concentration plots were rectilinear over the ranges 50-500 and 20-300 ng/mL for plasma and urine, respectively, detection limits of 1.81 and 0.54 ng/mL and quantification limits of 5.43 and 1.62 ng/mL for plasma and urine, respectively. The method presents good performance in terms of linearity, detection and quantification limits, precision, accuracy and specificity. The proposed method was successfully applied for the determination of tizanidine in pharmaceutical preparations. The results obtained were compared with a reference method, using t- and F-tests.

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A nano-level assay of tizanidine using the fluorogenic character of benzofurazan derivative: Application to plasma, tablets, and content homogeneity evaluation

AlSalem,

Alharbi,

Binkadem

et al. 2024

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Simultaneous estimation of valdecoxib and tizanidine hydrochloride in tablets by RP-HPLC

Cited by 6 publications

References 0 publications

Stability-Indicating Method for Determination of Tizanidine Hydrochloride in Pharmaceutical Lc-Cad Method Using Chemometric Approach

Stability-Indicating Method for Determination of Tizanidine Hydrochloride in Pharmaceutical Lc-Cad Method Using Chemometric Approach

Sensitive spectrofluorimetric determination of tizanidine in pharmaceutical preparations, human plasma and urine through derivatization with dansyl chloride

A nano-level assay of tizanidine using the fluorogenic character of benzofurazan derivative: Application to plasma, tablets, and content homogeneity evaluation

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