Simultaneous evaluation of benzotriazoles, benzothiazoles and benzenesulfonamides in water samples from the impacted urban Jacarepaguá Lagoon System (Rio de Janeiro, Brazil) by liquid chromatography coupled to electrospray tandem mass spectrometry

Ochs, Soraya de Mendonça; Souza, Thallis M.; Sobrinho, Rodrigo de Lima; Oliveira, Rodrigo Bueno de; Bernardes, Marcelo; Netto, Annibal Duarte Pereira

doi:10.1016/j.scitotenv.2022.160033

Cited by 7 publications

(1 citation statement)

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“…BTH (74.1 ng•L −1 ) and 2-ABTH (0.21 ng•L −1 ) were detected in Guangzhou, BTON (4.9 ng•L −1 ) [3,4] groundwater. MBT in Brazil's Tijuca Lagoon was as high as 2505 ng•L −1 [17]. BTH is mainly used as an intermediate for dyes, medicines, and rubber, with various pharmacological effects such as antibacterial, anti-inflammatory, anti-cancer, and anti-diabetic effects [18].…”

Section: Introductionmentioning

confidence: 99%

Comparing the Developmental Toxicity Delay and Neurotoxicity of Benzothiazole and Its Derivatives (BTHs) in Juvenile Zebrafish

Yin,

Wang,

Mao

2024

Toxics

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In this study, a semi-static water exposure method was employed to investigate the early developmental and neurotoxic effects of four benzothiazole substances (BTHs), namely benzothiazole (BTH), 2-mercaptobenzothiazole (MBT), 2-hydroxybenzothiazole (BTON), and 2-aminobenzothiazole (2-ABTH), on zebrafish at an equimolar concentration of 10 μM. The findings revealed that all four BTHs exerted certain impacts on early development in zebrafish. MBT stimulated spontaneous movement in juvenile zebrafish, whereas BTON inhibited such movements. Moreover, all four BTHs hindered the hatching process of zebrafish larvae, with MBT exhibiting the strongest inhibition at 24 h post-fertilization (hpf). Notably, MBT acted as a melanin inhibitor by suppressing melanin production in juvenile zebrafish eyes and weakening phototaxis. Additionally, both BTH and BTON exhibited significantly lower speeds than the control group and other test groups under conditions without bright field stimulation; however, their speeds increased to average levels after percussion stimulation, indicating no significant alteration in motor ability among experimental zebrafish groups. Short-term exposure to these four types of BTHs induced oxidative damage in zebrafish larvae; specifically, BTH-, MBT-, and BTON-exposed groups displayed abnormal expression patterns of genes related to oxidative damage. Exposure to both BTH and MBT led to reduced fluorescence intensity in transgenic zebrafish labeled with central nervous system markers, suggesting inhibition of central nervous system development. Furthermore, real-time quantitative PCR results demonstrated abnormal gene expression associated with neural development. However, no significant changes were observed in 2-ABTH gene expression at this concentration. Overall findings indicate that short-term exposure to BTHs stimulates neurodevelopmental gene expression accompanied by oxidative damage.

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