Simultaneous extraction and derivatization of 2-chlorovinylarsonous acid from soils using supercritical and pressurized fluids

Chaudot, Xavier; Tambute, A.; Caude, M.

doi:10.1016/s0021-9673(00)00506-9

Cited by 19 publications

(4 citation statements)

References 16 publications

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“…The method was used to detect hydrolysis product 2 at a former chemical-weapon storage site in the UK [20] and in water samples [21]. Aliphatic dithiols, such as ethane-1,2-dithiol and propane-1,3-dithiol, have been used to derivatise Lewisites I and II and their hydrolysis products [22][23][24][25][26][27][28][29]. Haas showed that a series of -dithiols, up to C 8 , and ethanethiol and propanethiol reacted with Lewisite I [29].…”

Section: LII Liiimentioning

confidence: 99%

Analysis of chemical warfare agents

Muir

Slater

Cooper

et al. 2004

Journal of Chromatography A

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Section: LII Liiimentioning

confidence: 99%

Analysis of chemical warfare agents

Muir

Slater

Cooper

et al. 2004

Journal of Chromatography A

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“…Reaction of intact or hydrolyzed LI may be accomplished using mono and bis-thiols. Aliphatic dithiols, such as 1,2-ethanedithiol and 1,3propanedithiol(PDT), have been used to derivatize LI and its hydrolysis products [8]. The results showed that the derivatives have favourable GC properties and mass spectral fragmentation patterns.…”

Section: Introductionmentioning

confidence: 99%

Trace Level Determination of Lewisite in Water by Solid-Phase Microextraction and Gas Chromatography-Mass Spectrometry with Selected Ion-Monitoring

Zhou¹,

Jianmei²,

Liu³

et al. 2008

2008 2nd International Conference on Bioinformatics and Biomedical Engineering

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A new analytical procedure was developed for the extraction of Lewisite of chemical warfare agents from water and for derivatization prior to analysis by gas chromatography-mass spectrometry (GC-MS) with selected ion-monitoring. Firstly ,lewisite and its degradation products 2-chlorovinylarsonous acid (CVAA) or 2-chlorovinylarsenous oxide(CVAO) or 2-chlorovinylarsonic acid (CVAOA) were derivatized with the propane-1,3-dithiol,then SPME with 100µm polydimethylsiloxane (PDMS) and analyzed. The experimental results indicated that the recoveries were more than 95%, the lowest detected concentration is 0.0002mg/L, and the relative standard deviation of seven injections is 3.2%. This method could satisfy the requirements for the destruction of abandoned chemical weapons by Japan in China.

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“…Bis(2-hydroxyethyl) sulfide (thiodiglycol, TDG,9) is the most important sulfur mustard decomposition product, as well as a starting material for its production, a compound listed in Schedule 2 of toxic chemicals in the Annex on Chemicals of the CWC. 1 Due to its high polarity and the absorptive nature, TDG is not extractable from water or soil using an organic solvent, except at a very high concentration, for the same reason it is also not easy to analyze it directly using GC.…”

Section: Introductionmentioning

confidence: 99%

Reaction of Lewisite-1 with Alcohols, Diols, and Thiols in Water—A Simple Method of Derivatization of Thiodiglycol

Sokolowski

Konopski

2007

Phosphorus, Sulfur, and Silicon and the Related Elements

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Reaction of 2-chlorovinyldichloroarsine (Lewisite-1) with alcohols, thiols, diols, and hydroxy thiols in water at 40 • C has been examined. The expected derivatization products, dialkyl 2-chlorovinylarsonites or corresponding arsonodithiolites, were obtained with alcohols and thiols, whereas reactions with bifunctional diols and hydroxythiols produced analogous cyclic esters. All derivatives may be easily detected using gas chromatography. This reaction was found useful to easily transform bis(2-hydroxyethyl) sulfide (thiodiglycol), a sulfur mustard decomposition product, to a stable eight-membered cyclic arsonite derivative. After extraction with dichloromethane, the derivative may be easily and selectively detected using GC/MS at a 100 ppb level thiodiglycol content in water matrices, eliminating tedious evaporation of water and then silylation. This method may be applied to analyze Chemical Weapons Convention related environmental water samples.

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Simultaneous extraction and derivatization of 2-chlorovinylarsonous acid from soils using supercritical and pressurized fluids

Cited by 19 publications

References 16 publications

Analysis of chemical warfare agents

Analysis of chemical warfare agents

Trace Level Determination of Lewisite in Water by Solid-Phase Microextraction and Gas Chromatography-Mass Spectrometry with Selected Ion-Monitoring

Reaction of Lewisite-1 with Alcohols, Diols, and Thiols in Water—A Simple Method of Derivatization of Thiodiglycol

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