Simultaneous fluorescence imaging monitoring of the programmed release of dual drugs from a hydrogel-carbon nanotube delivery system

Wei, Chang; Dong, Xia; Zhang, Yan; Liang, Jie; Yang, Afeng; Zhu, Dunwan; Liu, Tianjun; Kong, Deling; Lv, Feng

doi:10.1016/j.snb.2018.06.064

Cited by 50 publications

(23 citation statements)

References 43 publications

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“…For instance, by loading doxorubicin in chitosan‐coated carbon nanotubes and incorporating rhodamine B in the hydrogel matrix comprised by polycaprolactone‐polyethylene glycol‐polycaprolactone, researchers have demonstrated spatiotemporal programming of the two drugs. [ 59 ] At physiological conditions (pH ≈ 7.4), this platform showed distinct release rates with higher cumulative release of rhodamine B followed by doxorubicin, the latter which significantly enhanced its release rate when exposed to acidic conditions, unlike rhodamine B that maintained its passive diffusion‐mediated release kinetics. As showcased, designing nanocomposite hydrogels benefits from the added flexibility and ease for incorporating different bioactive compounds as well as encoding multimodal release rates to the meet the specifications of each drug and potentiate their effect.…”

Section: Stimuli‐responsive Nanocomposite Hydrogels and Biomedical Apmentioning

confidence: 99%

Stimuli‐Responsive Nanocomposite Hydrogels for Biomedical Applications

Lavrador

Esteves

Gaspar

et al. 2020

Adv Funct Materials

350

201

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The complex tissue‐specific physiology that is orchestrated from the nano‐ to the macroscale, in conjugation with the dynamic biophysical/biochemical stimuli underlying biological processes, has inspired the design of sophisticated hydrogels and nanoparticle systems exhibiting stimuli‐responsive features. Recently, hydrogels and nanoparticles have been combined in advanced nanocomposite hybrid platforms expanding their range of biomedical applications. The ease and flexibility of attaining modular nanocomposite hydrogel constructs by selecting different classes of nanomaterials/hydrogels, or tuning nanoparticle‐hydrogel physicochemical interactions widely expands the range of attainable properties to levels beyond those of traditional platforms. This review showcases the intrinsic ability of hybrid constructs to react to external or internal/physiological stimuli in the scope of developing sophisticated and intelligent systems with application‐oriented features. Moreover, nanoparticle‐hydrogel platforms are overviewed in the context of encoding stimuli‐responsive cascades that recapitulate signaling interplays present in native biosystems. Collectively, recent breakthroughs in the design of stimuli‐responsive nanocomposite hydrogels improve their potential for operating as advanced systems in different biomedical applications that benefit from tailored single or multi‐responsiveness.

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Section: Stimuli‐responsive Nanocomposite Hydrogels and Biomedical Apmentioning

confidence: 99%

Stimuli‐Responsive Nanocomposite Hydrogels for Biomedical Applications

Lavrador

Esteves

Gaspar

et al. 2020

Adv Funct Materials

350

201

View full text Add to dashboard Cite

show abstract

“…The difference of drug loading is pointed out as the source of the observed release rate. Furthermore, pH dependency was also noticed [98]. CNT based-hydrogels could also find applications in cancer therapy: Hindumathi et al confined CNT inside a PEG cocoon in order to load drugs such as curcumin, allowing curcumin cellular uptake [99].…”

Section: Cnt-based Hydrogels For Biomedical Applicationsmentioning

confidence: 99%

Overview of Carbon Nanotubes for Biomedical Applications

2019

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The unique combination of mechanical, optical and electrical properties offered by carbon nanotubes has fostered research for their use in many kinds of applications, including the biomedical field. However, due to persisting outstanding questions regarding their potential toxicity when considered as free particles, the research is now focusing on their immobilization on substrates for interface tuning or as biosensors, as load in nanocomposite materials where they improve both mechanical and electrical properties or even for direct use as scaffolds for tissue engineering. After a brief introduction to carbon nanotubes in general and their proposed applications in the biomedical field, this review will focus on nanocomposite materials with hydrogel-based matrices and especially their potential future use for diagnostics, tissue engineering or targeted drug delivery. The toxicity issue will also be briefly described in order to justify the safe(r)-by-design approach offered by carbon nanotubes-based hydrogels.

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“…Balb/c nude mice were subcutaneously administered with RB-DOX-CNTs/hydrogel and tracked by a multispectral fluorescence imaging system. Among the tested anti-cancer drugs, DOX exerted a significantly slower release rate vs. RB rate from hydrogel, affirming the system may prove a potential NDDP with programmed release of anti-cancer drugs in combined drug administration therapy for treatment of cancer [ 52 ]. Karthika et al (2018) [ 53 ] designed MWCNTs TiO 2 -Au to enhance the biocompatibility of NDDP for in vitro DOX delivery.…”

Section: Inorganic Nddps Implicated In Anti-cancer Therapymentioning

confidence: 99%

Advances in Therapeutic Implications of Inorganic Drug Delivery Nano-Platforms for Cancer

Naz

Shamoon

Wang

et al. 2019

IJMS

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Numerous nanoparticles drug delivery systems for therapeutic implications in cancer treatment are in preclinical development as conventional chemotherapy has several drawbacks. A chemotherapeutic approach requires high doses of chemotherapeutic agents with low bioavailability, non-specific targeting, and above all, development of multiple drug resistance. In recent years, inorganic nano-drug delivery platforms (NDDPs; with a metal core) have emerged as potential chemotherapeutic systems in oncology. One of the major goals of developing inorganic NDDPs is to effectively address the targeted anti-cancer drug(s) delivery related problems by carrying the therapeutic agents to desired tumors sites. In this current review, we delve into summarizing the recent developments in targeted release of anti-cancer drugs loaded in inorganic NDDPs such as mesoporous silica nanoparticles, carbon nanotubes, layered double hydroxides, superparamagnetic iron oxide nanoparticles and calcium phosphate nanoparticles together with highlighting their therapeutic performance at tumor sites.

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Simultaneous fluorescence imaging monitoring of the programmed release of dual drugs from a hydrogel-carbon nanotube delivery system

Cited by 50 publications

References 43 publications

Stimuli‐Responsive Nanocomposite Hydrogels for Biomedical Applications

Stimuli‐Responsive Nanocomposite Hydrogels for Biomedical Applications

Overview of Carbon Nanotubes for Biomedical Applications

Advances in Therapeutic Implications of Inorganic Drug Delivery Nano-Platforms for Cancer

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