Simultaneous Gastric and Colonic Metastasis of Breast Cancer

Abstract

Although breast cancer (BC) is the most common malignancy in women, metastasization to the gastrointestinal tract is rare. We present a 59-year-old woman with simultaneous gastric and colonic metastasis of invasive lobular breast carcinoma. She had been diagnosed with BC and underwent surgery and systemic therapy. Two years later, an increase in tumor markers motivated investigation, including upper and lower gastrointestinal endoscopy, which identified gastric ulcers and mucosal irregularity in the cecum. Histopathological analysis was compatible with gastric and colonic metastases from BC. We highlight the importance of biopsying every endoscopically visible lesion in patients with BC history.

Therapeutic Effects of CDK4/6 Inhibitors in Gastric and Colonic Metastases From Breast Cancer: A Case Report

“…Conversely, GI metastases are uncommon, and previous studies have reported that the occurrence of gastric and colonic metastases is as low as 3% and 5%, respectively [ 7 ]. Moreover, simultaneous gastric and colonic metastasis is exceptionally rare, with only eight documented cases, including the case presented in our study [ 8 ]. Breast cancer, especially the luminal type, demonstrates a persistent tendency to recur, often spanning a prolonged period that sometimes exceeds 20 years.…”