Simultaneous HPLC Determination of Peroxyacetic Acid and Hydrogen Peroxide

Pinkernell, Ulrich; Effkemann, and Stefan; Kärst, Uwe

doi:10.1021/ac9701750

Cited by 237 publications

(102 citation statements)

References 12 publications

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“…A reliable, fast, accurate, and low level detection of H 2 O 2 has been the central task in various fields of analytical chemistry from environmental protection [23,24] to biosensors utilizing enzymes [25][26][27][28][29][30]. There are several disadvantages of the enzyme-modified electrodes, such as instability, high cost of enzymes and complicated immobilization procedure.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of 3D porous CeO2/reduced graphene oxide xerogel composite and low level detection of H2O2

Jha

Kumar

Raj

et al. 2014

Electrochimica Acta

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a b s t r a c tA novel synthetic approach has been designed to prepare CeO 2 /reduced graphene oxide (rGO) xerogel composite. The CeO 2 /rGO xerogel composite electrode displays much enhanced performance for the catalytic reduction of H 2 O 2 than the single component CeO 2 . The CeO 2 /rGO modified glassy carbon electrode displayed a wide linear range (60.7 nM-3.0 M), and low level of detection limit (30.40 nM) for H 2 O 2 and much higher sensitivity than that of CeO 2 nanoparticles modified electrode. The sensor fabricated by the xerogel composite was fast, stable, and reliable to the detection of hydrogen peroxide.

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Section: Introductionmentioning

confidence: 99%

Synthesis of 3D porous CeO2/reduced graphene oxide xerogel composite and low level detection of H2O2

Jha

Kumar

Raj

et al. 2014

Electrochimica Acta

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“…Peroxyacetic acid (PAA) is a sterilizing agent increasingly used in food industry [1,2] because it provides reduction products (water and acetic acid) displaying no toxic properties, unlike chlorine-based oxidants [1,3,4]. At the same time, it is less expensive with respect to other disinfectants exhibiting a similar low environmental impact, such as ozone and ammonium quaternary salts.…”

Section: Introductionmentioning

confidence: 99%

“…They include titration procedures [9,10], spectrophotometric [11 -13] and conductivity [2] measurements, as well as gas-chromatographic [14 -15] and high-performance liquidchromatographic [1,16] approaches. Even though some of these approaches are characterized by high selectivity and quite low detection limits, they are in general unsuitable for on-line and in situ monitoring.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Detection of Peracetic Acid and Hydrogen Peroxide by Amperometry at Pt and Au Electrodes

et al. 2006

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Based on preliminary voltammetric investigations at both Pt and Au electrodes in aqueous solutions buffered at different pH values in the range 0 -10, two possible profitable triple-pulse amperometric approaches were developed for determining simultaneously peroxyacetic acid (PAA) and hydrogen peroxide present in the same samples. At both surfaces a pulsed waveform applied at rotating-disc electrodes was adopted to take advantage on one hand of the optimized signal reproducibility achieved by this potential multistep antifouling approach and on the other hand of the constant thickness of the diffusion layer, which is necessary when the recording of time-independent currents is desired. At a rotating-disc Pt electrode an anodic selective signal was indeed recorded for H 2 O 2 alone, while PAA contents could be inferred only from the difference of convenient signals, since at all pHs explored its sole cathodic reaction could be observed at potentials coincident with those proper for the reduction of H 2 O 2 too. The same pulse approach at Au electrodes instead provided totally independent signals for the two analytes considered, thus proving to be suitable for their independent detection. In fact, H 2 O 2 alone undergoes anodic oxidation also at this surface, while the reduction of PAA occurs at potentials less cathodic than those required for H 2 O 2 . At both electrodes, the best results turned out to be achieved at pH 0 in terms of both precision (AE 2 -4%) and detection limits (0.2 -0.3 mM), as well as of linear range which extended for about three orders of magnitude. The kinetics of the equilibrium involving the generation of H 2 O 2 from the reaction of PAA with water was also evaluated, since it was suspected of making unreliable the proposed amperometric approaches.

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“…Another method using high performance liquid chromatography [8] (HPLC) based on the oxidation of triphenylphosphine by hydrogen peroxide could be used for this assay in order to confirm the results of our experiments. Moreover, it could be interesting to study the impact of oxidation on anti-cancer drugs and monoclonal antibodies, in order to assess if very low quantities of hydrogen peroxide can affect their structure or mechanism of action.…”

Section: Perspectivesmentioning

confidence: 55%

Permeability and Release of Decontaminating Agent Used in Cytotoxic Reconstitution Units: Diffusion of Hydrogen Peroxide in IV Bags

Gérard

Huguet

Escalup

et al. 2017

Pharmaceutical Technology in Hospital Pharmacy

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AbstractIntroductionOxidant agents used for top-decontamination in cytotoxic reconstitution units may spread into IV bags. The amount of hydrogen peroxide passing through the bags and its release have been evaluated using wrapped or unwrapped infusion bags made of three layers of polyolefin (FreeflexMethods3 experiments were carried out using 2 packages of 30 bags of polyolefin with (package A) or without (package B) overwrapping. A 43 min decontamination cycle with HResultsA linear calibration curve over the concentration range of 0.00–2.70 ppm was used prior to each analysis. The concentration of HConclusion/DiscussionThese results allow removing overwrapping for a lean production system, with an extemporaneous use. However, the graduate release of H

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Simultaneous HPLC Determination of Peroxyacetic Acid and Hydrogen Peroxide

Cited by 237 publications

References 12 publications

Synthesis of 3D porous CeO2/reduced graphene oxide xerogel composite and low level detection of H2O2

Synthesis of 3D porous CeO2/reduced graphene oxide xerogel composite and low level detection of H2O2

Simultaneous Detection of Peracetic Acid and Hydrogen Peroxide by Amperometry at Pt and Au Electrodes

Permeability and Release of Decontaminating Agent Used in Cytotoxic Reconstitution Units: Diffusion of Hydrogen Peroxide in IV Bags

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