Simultaneous human herpesvirus 6-associated encephalitis and Guillain-Barré syndrome in a patient after matched unrelated donor haematopoietic stem cell transplantation

Tomaszewska, Agnieszka; Nasiłowska-Adamska, Barbara; Dzieciątkowski, Tomasz; Mariańska, B

doi:10.5114/aoms.2010.13912

Cited by 8 publications

(8 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most patients who develop GBS post-transplant recover after treatment with IVIG and/or PE [3] , [8] . Usually, neurological symptoms gradually improve within 1 to several months after these treatments [3] , [11] . In 1 report, although muscle strength remained unchanged after IVIG by day 88 after neurological symptom onset, the patient displayed rapid recovery of muscle strength by day 150 [5] .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Guillain–Barré syndrome after allogeneic bone marrow transplantation: Case report and literature review

et al. 2016

View full text Add to dashboard Cite

A 50-year-old man with acute myelogenous leukemia underwent allogeneic bone-marrow transplantation (BMT). He presented with severe diarrhoea 86 days post BMT and was diagnosed with graft-versus-host disease (GVHD) based on skin and rectal biopsies. He complained of numbness and weakness in the distal extremities at 114 days after BMT. His symptoms rapidly deteriorated and he required mechanical ventilation for respiratory failure. His clinical course and the findings of a nerve conduction study fulfilled the criteria for diagnosis of Guillain–Barré syndrome (GBS). Sural nerve biopsy revealed active demyelination and infiltration of macrophages and CD8+ T-cells. After three cycles of intravenous immunoglobulin therapy, his symptoms gradually improved, and he could eventually walk unassisted. Although GBS has been known to develop after allogeneic BMT, the pathogenesis remains unclear, and specific treatment regimens have not been well established. Here, we report a case of GBS, caused by an immune-mediated mechanism related to GVHD, which was successfully treated using intravenous immunoglobulin therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Additional articles were sourced manually by searching the citations of relevant articles. We included 10 full-text articles that described patients who developed GBS after BMT [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] ( Table 1 ) and 2 clinical review articles [13] , [14] .…”

Section: Methodsmentioning

confidence: 99%

Guillain–Barré syndrome after allogeneic bone marrow transplantation: Case report and literature review

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Other reported causes include infection with EBV, human herpes virus 6, and coccidioides, while a few case reports have implicated vaccines (pneumococcal and influenza) and calcineurin inhibitors (both tacrolimus and cyclosporine). [3,[16][17][18][19][20][21][22] Given the prevalence in prior case reports and the temporal relationship of CMV viremia in the present case, we believe our patient most likely developed GBS related to his CMV infection. Table 3 contains a comprehensive list of prior cases of CMV associated GBS following transplantation.…”

Section: Discussionmentioning

confidence: 99%

“…At time of follow up with neurology one year later, his symptoms had resolved. [5][6][7][8][9][10][11][12][13][14][15] 18 EBV [16,17] 2 HHV-6 [18] 1 Coccidioidomycosis [19] 1 Pneumococcal vaccine [20] 1 Influenza vaccine [21] 1 Tacrolimus [3,22] 2 Cyclosporine [23][24][25] 3 C. jejuni [26,27] 2 Note. CMV = Cytomegalovirus; EBV = Ebstein-Barr virus; HHV = Human Herpes virus; C. jejuni = Campylobacter jejuni.…”

Section: Case Presentationmentioning

confidence: 99%

Guillain-Barré syndrome following heart transplantation complicated by myocardial infarction following treatment with IVIg

Newman

Chen

Rana

et al. 2017

CRIM

View full text Add to dashboard Cite

Guillain-Barré syndrome (GBS) is rare autoimmune polyneuropathy that is infrequently seen in the post-transplant population, presumably due to the presence of immunosuppression. When it does occur in this setting, Cytomegalovirus (CMV) infection is a common inciting factor. Treatment modalities for GBS include intravenous immunoglobulin (IVIg) or plasmapheresis. Rarely, IVIg infusion has been associated with myocardial infarction. We describe a case of a patient status post heart transplantation who presented with GBS shortly after developing CMV viremia. When treatment with IVIg was initiated, our patient developed myocardial infarction with acute cardiac biomarker elevation, acute systolic dysfunction, and cardiogenic shock requiring inotropic and vasopressor support. Coronary angiography demonstrated no significant coronary artery disease. The patient's cardiac function recovered, as did the GBS following initiation of plasmapheresis. We review prior cases of GBS in transplant patients as well as IVIg associated myocardial infarction.

show abstract

“…Increasing use of RQ-PCR in clinical diagnostics in recent years has made this technique an essential tool in laboratory detection of many infections [1,2]. RQ-PCR outrivals classic PCR due to many advantages, including improved speed, sensitivity, lower intra- and inter-assay variability, and increased specificity.…”

Section: Introductionmentioning

confidence: 99%

Udoskonalona metoda real-time PCR do identyfikacji i oceny ilościowej zakażeń wywołanych przez 54 serotypy ludzkich adenowirusów w próbkach klinicznych

Bil‐Lula¹,

Franceschi

Pawlik

et al. 2012

Med Sci Monit

View full text Add to dashboard Cite

SummaryBackgroundDetection and quantification of adenoviruses (AdVs) causing life-threatening complications are important abilities in recognition of infection and management of immunocompromised patients. Due to the rapid increase in the number of known AdV types, most commercial tests for detection and identification of AdVs are outdated.Material/MethodsWe designed an improved, easier and faster real-time quantitative polymerase chain reaction (RQ-PCR) method for detection and quantification of 54 types of human AdVs. A wide validation effort was undertaken to ensure confidence in highly sensitive and specific detection of AdVs in compromised patients. The validation process included evaluation of the method’s suitability and reliability for use in routine diagnostics.ResultsDue to high sensitivity (9.2×102 copies/ml) and broad dynamic range (7 log) we are able to detect specific viral DNA in large amounts of cell-free body fluids. The new assay is characterized by high precision and low variation within and between individual virus tests (CV=0.036%, CV=1.29%), low bias error (4%) and no cross-reactivity with other pathogens.ConclusionsThe implementation of this new assay in clinical and laboratory practice provides a rapid, reliable and less laborious method for detection and monitoring of AdV replication in immunocompromised patients. Moreover, it offers the ability to distinguish between active and latent infection and assess treatment efficiency.

show abstract

Simultaneous human herpesvirus 6-associated encephalitis and Guillain-Barré syndrome in a patient after matched unrelated donor haematopoietic stem cell transplantation

Cited by 8 publications

References 10 publications

Guillain–Barré syndrome after allogeneic bone marrow transplantation: Case report and literature review

Guillain–Barré syndrome after allogeneic bone marrow transplantation: Case report and literature review

Guillain-Barré syndrome following heart transplantation complicated by myocardial infarction following treatment with IVIg

Udoskonalona metoda real-time PCR do identyfikacji i oceny ilościowej zakażeń wywołanych przez 54 serotypy ludzkich adenowirusów w próbkach klinicznych

Contact Info

Product

Resources

About