Simultaneous Inference

Abstract

This covers statistical procedures to assess either more than one parameter or one parameter repeatedly during the course of a study. It includes multiple comparisons, multiple endpoints, sequential methods, and longitudinal data analysis. A common approach is to control the per‐family error rate (expected number of false positive conclusions per study) or the experimentwise error rate (probability of at least one false positive). Examples are given, with particular reference to problems of data monitoring of clinical trials.