Simultaneous integrated boost for mediastinal lymph node recurrence after radical surgery for esophageal cancer: Interim results from a phase I/II prospective study

Qi, Wei-Xiang; Zheng, Siyue; Cao, Lu; Xu, Cheng; Zhao, Shan; Chen, Jiayi

doi:10.1111/1759-7714.13891

Cited by 2 publications

(1 citation statement)

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“…The study was designed as a retrospective design from our prospective trials (NCT NCT04435197, NCT04435197, NCT04513418, NCT03990532) (25)(26)(27), and all included patients were treated with nCRT and PD-1 inhibitors followed by esophagectomy at Ruijin Hospital, Shanghai Jiao Tong university school of medicine, between Jan 2019 and July 2023. All included patients received standardized neoadjuvant chemoradiotherapy.…”

Section: Study Papulationmentioning

confidence: 99%

A machine learning approach using 18F-FDG PET and enhanced CT scan-based radiomics combined with clinical model to predict pathological complete response in ESCC patients after neoadjuvant chemoradiotherapy and anti-PD-1 inhibitors

Qi,

Li,

Xiao

et al. 2024

Front. Immunol.

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BackgroundWe aim to evaluate the value of an integrated multimodal radiomics with machine learning model to predict the pathological complete response (pCR) of primary tumor in a prospective cohort of esophageal squamous cell carcinoma (ESCC) treated with neoadjuvant chemoradiotherapy (nCRT) and anti-PD-1 inhibitors.Materials and methodsClinical information of 126 ESCC patients were included for analysis. Radiomics features were extracted from 18F-FDG PET and enhanced plan CT images. Four machine learning algorithms, including SVM (Support Vector Machine), Random Forest (RF), and eXtreme Gradient Boosting (XGB) and logistic regression (LR), were applied using k-fold cross-validation to predict pCR after nCRT. The predictive ability of the models was assessed using receiver operating characteristics (ROC) curve analysis.ResultsA total of 842 features were extracted. Among the four machine learning algorithms, SVM achieved the most promising performance on the test set for PET(AUC:0.775), CT (AUC:0.710) and clinical model (AUC:0.722). For all combinations of various modalities-based models, the combination model of 18 F-FDG PET, CT and clinical features with SVM machine learning had the highest AUC of 0.852 in the test set when compared to single-modality models in various algorithms. The other combined models had AUC ranged 0.716 to 0.775.ConclusionMachine learning models utilizing radiomics features from 18F-FDG PET and enhanced plan CT exhibit promising performance in predicting pCR in ESCC after nCRT and anti-PD-1 inhibitors. The fusion of features from multiple modalities radiomics and clinical features enhances the better predictive performance compared to using a single modality alone.

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Section: Study Papulationmentioning

confidence: 99%