Simultaneous intracellular nanorheology and nanothermometry using diamond quantum sensing

Gu, Qiushi; Shanahan, Louise; Hart, Jack W.; Belser, Sophia; Noah, Shofer,; Atatüre, Mete; Knowles, Helena S.

doi:10.1364/fio.2022.jw4a.75

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…For example, orientation tracking of FNDs located on the cell membrane can be correlated with cell metabolic activities. [49,77,78] Usually, such measurements are done using a confocal imaging setup and single particle tracking analysis of the diffusing nanodiamond. This requires a complicated analysis of the fields and trajectories.…”

Section: Uncontrolled Rotationmentioning

confidence: 99%

Spatial Manipulation of Fluorescent Colloidal Nanodiamonds for Applications in Quantum Sensing

Vashist,

Ghosh,

Ghosh

2023

Advanced Physics Research

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Nitrogen vacancy (NV) centers in diamonds are of current interest as quantum sensors, single photon sources, and biological nanomaterials due to their unique optical and spin properties, biocompatibility, and robust structure. Though NV center in diamonds demonstrates longer coherence time and has been used for more sensing and quantum operations compared to nanodiamonds (NDs), the prospect of selecting NDs with single, few, or multiple NV centers and moving the NDs to the location of interest makes NDs suitable for various applications, due to which there is a significant boost in the last decade to manipulate and position the NDs on the surface or to achieve dynamic control in the fluidic environment. This work covers some of the basics of the materials and optical properties of nanodiamonds and discusses the capabilities and challenges for practical applications, followed by a detailed review of the various static and dynamic manipulation methods of nanodiamonds in microfluidic environments (colloidal NDs).

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Section: Uncontrolled Rotationmentioning

confidence: 99%

Spatial Manipulation of Fluorescent Colloidal Nanodiamonds for Applications in Quantum Sensing

Vashist,

Ghosh,

Ghosh

2023

Advanced Physics Research

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“…They are the basis of ultrasentisive diagnostics with orders of magnitude enhanced sensitivity in biomarker detection (Miller et al, 2020) and could enable nanoparticle-based drug delivery with integrated nanosensor in model systems (Chauhan et al, 2020). The ability of NV centres to operate concurrently in different modalities opens the door to implementing interleaved protocols, where multiple parameters are measured simultaneously or in fast succession, without the need to correlate results from different sensors and different experimental runs (Gu et al, 2023). This unique feature of NV centres facilitates experiments to probe the interdependence of multiple properties at the same time.…”

Section: Challenges and Future Opportunitiesmentioning

confidence: 99%

Multimodal quantum metrology in living systems using nitrogen-vacancy centres in diamond nanocrystals

Hart

Knowles

2023

Front. Quantum Sci. Technol.

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Nitrogen-vacancy centres in diamond nanocrystals are among the leading candidates for realising nanoscale quantum sensing under ambient conditions. Due to their exceptional electronic spin coherence at room temperature and optical addressability, these solid state spin-based sensors can achieve a wide selection of sensing modalities, including probing temperature, external magnetic and electric field, as well as the detection of nearby electronic and nuclear spins. In this article, we discuss recent progress made utilizing nanodiamond quantum sensors in living systems and explore both opportunities for future advances and challenges that lie ahead.

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Opportunities for diamond quantum metrology in biological systems

Belser

Hart

et al. 2023

Applied Physics Letters

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Sensors that harness quantum mechanical effects can enable high sensitivity and high spatial resolution probing of their environment. The nitrogen-vacancy defect in diamond, a single, optically accessible electronic spin, is a promising quantum sensor that can operate in soft and living systems and provides nanoscale spatial resolution when hosted inside a diamond nanoparticle. Nanodiamond quantum sensors are nontoxic, amenable to surface functionalization, and can be introduced into a variety of living systems. The optical readout of the spin provides detailed information about the local electromagnetic and thermal environment in a noninvasive way. In this Perspective, we introduce the different modalities that nanodiamond quantum sensors offer, highlight recent progress in quantum sensing of biological systems, and discuss remaining challenges and directions for future efforts.

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Simultaneous intracellular nanorheology and nanothermometry using diamond quantum sensing

Cited by 3 publications

References 4 publications

Spatial Manipulation of Fluorescent Colloidal Nanodiamonds for Applications in Quantum Sensing

Spatial Manipulation of Fluorescent Colloidal Nanodiamonds for Applications in Quantum Sensing

Multimodal quantum metrology in living systems using nitrogen-vacancy centres in diamond nanocrystals

Opportunities for diamond quantum metrology in biological systems

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