Simultaneous isolation of Rutin and Esculin from plant material and drugs using solid-phase extraction

Buszewski, Bogusław; Kawka, S.; Suprynowicz, Z.; Wolski, T.

doi:10.1016/0731-7085(93)80199-b

Cited by 29 publications

(14 citation statements)

References 7 publications

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“…From stem bark were isolated two pentacyclic triterpenes acyl lupeols (1 and 2, 25 mg, Brum et al, 1998); two coumarins, coumarin (3, 6.5 mg, Tonin & Tavares, 2002) and scopoletin (4, 4.0 mg, Silva et al, 2002); four flavonoids, naringenin (5, 2.5 mg, Almeida et al, 2005), kaempferol (6, 6 mg, Oliveira et al, 1999), quercetin (7, 4.5 mg, Barberá, 1986;Agrawal & Bansal, 1989) and myricitrin (9, 155.0 mg, Timbola et al, 2002), besides 2-methoxy-4-hydroxy-benzoic acid (11, 12 mg, Scott, 1972). From the leaves were isolated the flavonoid rutin (8, 7 mg, Buszewski et al, 1993;Agrawal & Bansal, 1989) and a pentacyclic triterpene ursolic acid (10, 20 mg, Tkachev et al, 2004). The compounds 9 and 11 were also isolated from the woods.…”

Section: Resultsmentioning

confidence: 99%

Chemotaxonomic significance of flavonoids, coumarins and triterpenes of Augusta longifolia (Spreng.) Rehder, Rubiaceae-Ixoroideae, with new insights about its systematic position within the family

Choze¹,

Delprete²,

Lião³

2010

Rev. bras. farmacogn.

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RESUMO: "Significância quimiotaxômica de flavonoides, cumarinas e triterpenos de Augusta longifolia (Spreng.) Rehder, Rubiaceae-Ixoroideae, com novos entendimentos sobre a posição sistemática dentro da família". Augusta tem sido tradicionalmente colocada na tribo Rondeletieae, Cinchonoideae subfamília. No entanto, recentes filogenias moleculares posicionou-a perto de Wendlandia, porém localizando A. longifolia perto do clado Ixoroidinae II. O estudo de A. longifolia resultou em duas cumarinas, cinco flavonoides, três triterpenoides e um derivado do ácido benzóico. Estes metabolitos reforçam a separação da Augusta como um gênero monoespecífico, e Lindenia como um gênero de três espécies, intimamente relacionada com Wendlandia.Unitermos: Rubiaceae, Augusta, Wendlandia, Lindenia, quimiotaxonomia.ABSTRACT: Augusta has traditionally been placed in the tribe Rondeletieae, subfamily Cinchonoideae. However, recent molecular phylogenies positioned it near to Wendlandia (Ixoroideae), but locate A. longifolia near to the clade Ixoroidinae II. The study of A. longifolia afforded two coumarins, five flavonoids, three triterpenoids and one benzoic acid derivative. These metabolites reinforce the separation of Augusta as a monospecific genus, and Lindenia as a genus of three species, closely related to Wendlandia.

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Section: Resultsmentioning

confidence: 99%

Chemotaxonomic significance of flavonoids, coumarins and triterpenes of Augusta longifolia (Spreng.) Rehder, Rubiaceae-Ixoroideae, with new insights about its systematic position within the family

Choze¹,

Delprete²,

Lião³

2010

Rev. bras. farmacogn.

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“…Currently, extraction methods such as supercritical fluid extraction (SFE) and solid phase microextraction (SPME) are successfully applied for the characterisation of hops and other plants raw material aromatic properties (Kovačevič and Kač 2001;Ravenchon 1997;Ligor and Buszewski 1999;Ligor et al 2000). Moreover, other extraction methods including solid-phase extraction (SPE) and solvent extraction are successfully used for the isolation of nonvolatile compounds from plant materials (Buszewski et al 1993a;Ligor et al 2008). SPE in off-line columns has become a popular and effective method of sample preparation, particularly for purification and/or isolation of polyphenolic compounds present in biological materials and natural products (Buszewski et al 1993a,b).…”

Section: Introductionmentioning

confidence: 99%

Comparative Gas Chromatographic–Mass Spectrometric Evaluation of Hop (Humulus lupulus L.) Essential Oils and Extracts Obtained Using Different Sample Preparation Methods

et al. 2013

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The main aim of investigations was to identify chemotypes and determine differences between some domestic hop varieties and wild hops, which were collected from some regions of Lithuania and cultivated at the same edafoclimatic conditions in hops collection of Kaunas Botanical Garden of Vytautas Magnus University. One of objectives was to compare essential oils of hops (2 years harvest) by the evaluation of volatiles content. Among the main components of hop essential oils monoterpenes (β-myrcene) and sesquiterpenes (α-humulene and β-caryophyllene) were determined using gas chromatography coupled with mass spectrometry (GC-MS). Retention parameters (t R , calculated retention index, and Kovats retention index) and m /z value of molecular ion for selected compounds from hop essential oils were determined. Samples were prepared by applying solid phase microextraction (SPME), supercritical fluid extraction (SFE) and accelerated solvent extraction (ASE). The steam distillation was used to obtain hop essential oils. The chemometric comparison of domestic and wild hops based on GC-MS analysis data was carried out. The obtained statistical results allow us to classify the investigated wild forms and domestic varieties of hops according to the similarities of their chemotypes. The concentration of β-myrcene, α-humulene in hop essential oils obtained from cones 2 years harvests is much higher than other volatile organic compounds (15.2-23.7 % in total contribution). In analysed essential oils β-farnesene is a constituent in higher quantity of hop essential oils obtained from cones from second time harvest than from cones from first harvest. This can be explained by the year-toyear vegetation conditions difference.

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“…5 A number of studies have proved that flavonoids and phenolics have wide range of physiological functions due to their potent anti-oxidant activity. 6 Rutin (3′,4′,5,7-tetrahydroxy-flavone-3-rutinoside) (Figure 1a), a common dietary flavonoid with a wide range of pharmacological activities is present in many plants (as buckwheat seeds, tea), fruits (citrus fruits, apple), vegetables (onion), and red wine etc,. 7 Different studies have represented the biological effects of Rutin, such as anti-oxidative, antiinflammatory, antihypertensive, anti-carcinogenic, cytoprotective, and cardio protective activities.…”

Section: Introductionmentioning

confidence: 99%

Chemo Preventive Effect of Rutin Against N-Nitrosodiethylamine-Induced and Phenobarbital- Promoted Hepatocellular Carcinoma in Wistar Rats

Chandra¹,

Viswanathswamy²

2018

IJPER

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Background: In recent years, a large number of natural compounds have been identified and proved to have a potential cancer chemopreventive importance due to their strong antioxidant and cytotoxic activities. Objective: The present study is designed to investigate the preventive effects of Rutin against N-Nitrosodiethylamine-induced and Phenobarbital-promoted Hepatocellular carcinoma in male wistar rats. Materials and Methods: Twenty-four male wistar rats were divided into four groups (n=6). Group I serve as Control, Group II was induced HCC by DEN (200mg/kg b.wt) followed by phenobarbital (0.05 % w/v), Group III received same as Group II and followed by Rutin (50mg/kg b.wt) and Group IV received Rutin alone at a dose of 50mg/kg b.wt, up to 16 successive weeks. Results: Results observed that there is significant increase in relative liver weight and liver marker enzymes (P<0.001), tumor marker enzymes (AFP, CEA at P<0.001) and also Significant abnormalities were observed in membrane bound enzymes and Electrolytes, whereas the above said alterations were significantly restored in Rutin treated group compared with DEN treated Group. Conclusion: The results of these findings suggested that Rutin can be used as an adjunct to conventional chemopreventive agent, which may provide a novel therapeutic approach to serve as a promising agent for treatment of Hepatocellular carcinoma.

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Simultaneous isolation of Rutin and Esculin from plant material and drugs using solid-phase extraction

Cited by 29 publications

References 7 publications

Chemotaxonomic significance of flavonoids, coumarins and triterpenes of Augusta longifolia (Spreng.) Rehder, Rubiaceae-Ixoroideae, with new insights about its systematic position within the family

Chemotaxonomic significance of flavonoids, coumarins and triterpenes of Augusta longifolia (Spreng.) Rehder, Rubiaceae-Ixoroideae, with new insights about its systematic position within the family

Comparative Gas Chromatographic–Mass Spectrometric Evaluation of Hop (Humulus lupulus L.) Essential Oils and Extracts Obtained Using Different Sample Preparation Methods

Chemo Preventive Effect of Rutin Against N-Nitrosodiethylamine-Induced and Phenobarbital- Promoted Hepatocellular Carcinoma in Wistar Rats

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