“…Sensors are crucial tools that connect the real world with digital data, , where sensitive materials work as the key elements that need to be specifically discussed. High-frequency electromagnetic wave sensors garnered significant attention, which are distinguished by their high reliability, rapid response, and cost-effectiveness compared to other sensors motivated by optics, acoustics, etc., attributing it as a research hotspot. − Recent advancements in the field have evidenced a paradigm shift in research focus, transitioning from traditional design optimization toward the exploration and incorporation of innovative materials. − These new materials, characterized by their unique electromagnetic properties, surface properties, and nanostructure designs, not only enhance the performance of high-frequency electromagnetic sensors for offering unprecedented sensitivity, selectivity, and miniaturization but also pioneer new application domains such as toxic gas, disease biomarkers, solid properties, etc. − Incorporating new materials into sensor design primarily aims to improve their response to high-frequency signals. Recently, sensitive two-dimensional (2D) materials like graphene and MXene, known for their large surface areas, show great promise in detecting humidity and VOCs with high sensitivity and selectivity. , Additionally, specially designed biomaterials have been used in antigen–antibody sensors to successfully detect coronaviruses at low concentrations, highlighting the significant impact of material innovation in enhancing sensor performance …”