Simultaneous measurement of tissue oxygen level‐dependent (TOLD) and blood oxygenation level‐dependent (BOLD) effects in abdominal tissue oxygenation level studies

Ding, Yao; Mason, Ralph P.; McColl, Roderick W; Yuan, Qing; Hallac, Rami R.; Sims, Robert; Weatherall, Paul T.

doi:10.1002/jmri.24006

Cited by 30 publications

(25 citation statements)

References 21 publications

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“…TOLD imaging tends to be slower and therefore even more susceptible to motion. In some cases, echo planar imaging sequences have proven successful as recently demonstrated in human mediastinal organs (kidney, spleen) , but in lung echo planar imaging is subject to severe distortions. As shown here, both R 1 and

R_{2}^{*}

responses are related to pO 2 .…”

Section: Discussionmentioning

confidence: 99%

Correlations of noninvasive BOLD and TOLD MRI with pO₂ and relevance to tumor radiation response

et al. 2013

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Purpose To examine the potential use of BOLD (Blood Oxygenation Level Dependent) and TOLD (Tissue Oxygenation Level Dependent) contrast MRI to assess tumor oxygenation and predict radiation response. Methods BOLD and TOLD MRI were performed on Dunning R3327-AT1 rat prostate tumors during hyperoxic gas breathing challenge at 4.7 T. Animals were divided into two groups. In Group 1 (n=9), subsequent 19F MRI based on spin lattice relaxation of hexafluorobenzene reporter molecule provided quantitative oximetry for comparison. For Group 2 rats (n=13) growth delay following a single dose of 30 Gy was compared with pre-irradiation BOLD and TOLD assessments. Results Oxygen (100%O2) and carbogen (CB; 95%O2/5%CO2) challenge elicited similar BOLD, TOLD and pO2 responses. Strong correlations were observed between BOLD or R2* response and quantitative 19F pO2 measurements. TOLD response showed a general trend with weaker correlation. Irradiation caused a significant tumor growth delay and tumors with larger changes in TOLD and R1 values upon oxygen breathing exhibited significantly increased tumor growth delay. Conclusion These results provide further insight into the relationships between oxygen sensitive (BOLD/TOLD) MRI and tumor pO2. Moreover, a larger increase in R1 response to hyperoxic gas challenge coincided with greater tumor growth delay following irradiation.

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R_{2}^{*}

responses are related to pO 2 .…”

Section: Discussionmentioning

confidence: 99%

Correlations of noninvasive BOLD and TOLD MRI with pO₂ and relevance to tumor radiation response

et al. 2013

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“…A significant increase in R 1 values was observed in eight of these patients with ovarian, cervical, or gastrointestinal malignancies (117). The effect of hyperoxia has also been investigated in the brain using a dynamic T 1 -weighted sequence called tissue oxygen level dependent (TOLD) (118). This method allows reduced acquisition times and is more suited for a dynamic assessment of changes induced by a hyperoxic challenge.…”

Section: Mri Methodsmentioning

confidence: 99%

“…As there is a real interest in combining the measurement of R 1 and

R_{2}^{*}

, Ding and colleagues have recently proposed a new sequence enabling simultaneous acquisition of

T_{2}^{*}

and T 1 measurement. With this new method, they monitored the dynamic changes in oxygenation of abdominal organs (spleen, medulla, and renal cortex) (118). …”

Section: Mri Methodsmentioning

confidence: 99%

Assessing Tumor Oxygenation for Predicting Outcome in Radiation Oncology: A Review of Studies Correlating Tumor Hypoxic Status and Outcome in the Preclinical and Clinical Settings

2017

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Tumor hypoxia is recognized as a limiting factor for the efficacy of radiotherapy, because it enhances tumor radioresistance. It is strongly suggested that assessing tumor oxygenation could help to predict the outcome of cancer patients undergoing radiation therapy. Strategies have also been developed to alleviate tumor hypoxia in order to radiosensitize tumors. In addition, oxygen mapping is critically needed for intensity modulated radiation therapy (IMRT), in which the most hypoxic regions require higher radiation doses and the most oxygenated regions require lower radiation doses. However, the assessment of tumor oxygenation is not yet included in day-to-day clinical practice. This is due to the lack of a method for the quantitative and non-invasive mapping of tumor oxygenation. To fully integrate tumor hypoxia parameters into effective improvements of the individually tailored radiation therapy protocols in cancer patients, methods allowing non-invasively repeated, safe, and robust mapping of changes in tissue oxygenation are required. In this review, non-invasive methods dedicated to assessing tumor oxygenation with the ultimate goal of predicting outcome in radiation oncology are presented, including positron emission tomography used with nitroimidazole tracers, magnetic resonance methods using endogenous contrasts (R1 and R2*-based methods), and electron paramagnetic resonance oximetry; the goal is to highlight results of studies establishing correlations between tumor hypoxic status and patients’ outcome in the preclinical and clinical settings.

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“…For example, blood flow can contribute to recovery of tissue water 1 H longitudinal magnetization, masking the contribution of dissolved O 2 to the overall relaxation process. Nevertheless, oxygen- sensitive MRI experiments, coupled with breathing-gas modulation, have been used to non-invasively interrogate tissue oxygenation in tumor (2,3,8,27), radiation treatment (29), and a number of control-state (normal, healthy) organs (1,5,7,30). …”

Section: Introductionmentioning

confidence: 99%

O₂‐sensitive MRI distinguishes brain tumor versus radiation necrosis in murine models

Beeman

Shui

Pérez-Torres

et al. 2015

Magnetic Resonance in Med

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Purpose To quantify the relationship between 1H longitudinal relaxation rate constant, R1, and O2 concentration (relaxivity, r1) in tissue and to quantify O2-driven changes in R1 (ΔR1) during a breathing gas challenge in normal brain, radiation-induced lesions, and tumor lesions. Methods Relaxivity determination. R1 data were collected in control-state mice (n=4) during three different breathing gas (and thus tissue O2) conditions. In parallel experiments, pO2 was measured in the thalamus of control-state mice (n=4) under the same breathing gas conditions using an O2-sensitive micro-probe. The relaxivity of tissue O2 was calculated using the R1 and pO2 data. Pathology determination. R1 data were collected in control-state (n=4) mice, a glioma model (n=7), and a radiation necrosis model (n=6) during two breathing gas (thus tissue O2) conditions. R1 and ΔR1 were calculated for each cohort. Results O2 r1 in the brain was 9×10−4±3×10−4 mmHg−1s−1 at 4.7T. R1 and ΔR1 measurements distinguished radiation necrosis from tumor (p<0.03 and p<0.01, respectively). Conclusion The relaxivity of O2 in brain is determined. R1 and ΔR1 measurements differentiate tumor lesions from radiation necrosis lesions in the mouse models. These pathologies are difficult to distinguish by traditional imaging techniques; O2-driven changes in R1 holds promise in this regard.

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Simultaneous measurement of tissue oxygen level‐dependent (TOLD) and blood oxygenation level‐dependent (BOLD) effects in abdominal tissue oxygenation level studies

Cited by 30 publications

References 21 publications

Correlations of noninvasive BOLD and TOLD MRI with pO₂ and relevance to tumor radiation response

Correlations of noninvasive BOLD and TOLD MRI with pO₂ and relevance to tumor radiation response

Assessing Tumor Oxygenation for Predicting Outcome in Radiation Oncology: A Review of Studies Correlating Tumor Hypoxic Status and Outcome in the Preclinical and Clinical Settings

O₂‐sensitive MRI distinguishes brain tumor versus radiation necrosis in murine models

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Simultaneous measurement of tissue oxygen level‐dependent (TOLD) and blood oxygenation level‐dependent (BOLD) effects in abdominal tissue oxygenation level studies

Cited by 30 publications

References 21 publications

Correlations of noninvasive BOLD and TOLD MRI with pO2 and relevance to tumor radiation response

Correlations of noninvasive BOLD and TOLD MRI with pO2 and relevance to tumor radiation response

Assessing Tumor Oxygenation for Predicting Outcome in Radiation Oncology: A Review of Studies Correlating Tumor Hypoxic Status and Outcome in the Preclinical and Clinical Settings

O2‐sensitive MRI distinguishes brain tumor versus radiation necrosis in murine models

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Product

Resources

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Correlations of noninvasive BOLD and TOLD MRI with pO₂ and relevance to tumor radiation response

Correlations of noninvasive BOLD and TOLD MRI with pO₂ and relevance to tumor radiation response

O₂‐sensitive MRI distinguishes brain tumor versus radiation necrosis in murine models