Simultaneous measurements of myocardial glucose metabolism and extracellular volumes with hybrid PET/MRI using concurrent injections of Gd-DTPA and [18F]FDG

Smailovic, H; Wilk, Benjamin; Wisenberg, Gerald; Sykes, Jane; Butler, John; Hicks, Justin; Thiessen, Jonathan D.; Prato, Frank S.

doi:10.1007/s12350-020-02486-6

Journal of Nuclear Cardiology

2022

DOI: 10.1007/s12350-020-02486-6

|View full text |Cite

Simultaneous measurements of myocardial glucose metabolism and extracellular volumes with hybrid PET/MRI using concurrent injections of Gd-DTPA and [18F]FDG

H Smailovic

Benjamin Wilk

Gerald Wisenberg

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

2024

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The combination of pre-and postcontrast T1 maps can give a measure of the extracellular volume (ECV), where an increase relates to myocardial fibrosis and correlates with an increasing likelihood of cardiac events (12). The optimal means of quantifying ECV is during a slow, constant infusion of a gadolinium tracer, with a constant concentration of a tracer being supplied to the myocardium during the capture of 3-dimensional T1 maps (13). Lastly, increases in the T2 relaxation rate correlate with an increase in extracellular water, that is, edema.…”

mentioning

confidence: 99%

PET/MRI Assessment of Acute Cardiac Inflammation 1 Month After Left-Sided Breast Cancer Radiation Therapy

Chau

Islam

Lock

et al. 2023

J. Nucl. Med. Technol.

View full text Add to dashboard Cite

Our purpose was to investigate the utility of 18 F-FDG PET/MRI and serial blood work to detect early inflammatory responses and cardiac functionality changes at 1 mo after radiation therapy (RT) in patients with left-sided breast cancer. Methods: Fifteen left-sided breast cancer patients who enrolled in the RICT-BREAST study underwent cardiac PET/MRI at baseline and 1 mo after standard RT. Eleven patients received deep-inspiration breath-hold RT, whereas the others received free-breathing RT. A list-mode 18 F-FDG PET scan with glucose suppression was acquired. Myocardial inflammation was quantified by the change in 18 F-FDG SUV mean (based on body weight) and analyzed on the basis of the myocardial tissue associated with the left anterior descending, left circumflex, or right coronary artery territories. MRI assessments, including left ventricular functional and extracellular volumes (ECVs), were extracted from T1 (before and during a constant infusion of gadolinium) and cine images, respectively, acquired simultaneously during the PET acquisition. Cardiac injury and inflammation biomarker measurements of high-sensitivity troponin T, high-sensitivity C-reactive protein, and erythrocyte sedimentation rate were measured at the 1-mo follow-up and compared with preirradiation values. Results: At the 1-mo follow-up, a significant increase (10%) in myocardial SUV mean in left anterior descending segments (P 5 0.04) and ECVs in slices at the apex (6%) and base (5%) was detected (P # 0.02). Further, a significant reduction in left ventricular stroke volume (27%) was seen (P , 0.02). No significant changes in any circulating biomarkers were seen at follow-up. Conclusion: Myocardial 18 F-FDG uptake and functional MRI, including stroke volume and ECVs, were sensitive to changes at 1 mo after breast cancer RT, with findings suggesting an acute cardiac inflammatory response to RT.

show abstract

mentioning

confidence: 99%

PET/MRI Assessment of Acute Cardiac Inflammation 1 Month After Left-Sided Breast Cancer Radiation Therapy

Chau

Islam

Lock

et al. 2023

J. Nucl. Med. Technol.

View full text Add to dashboard Cite

show abstract

Tracking the progress of inflammation with PET/MRI in a canine model of myocardial infarction

Wilk

Smailovic

Wisenberg

et al. 2022

Journal of Nuclear Cardiology

View full text Add to dashboard Cite

Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2022: positron emission tomography, computed tomography, and magnetic resonance

Murphy

AlJaroudi

Hage

2023

Journal of Nuclear Cardiology

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Simultaneous measurements of myocardial glucose metabolism and extracellular volumes with hybrid PET/MRI using concurrent injections of Gd-DTPA and [18F]FDG

Cited by 5 publications

References 32 publications

PET/MRI Assessment of Acute Cardiac Inflammation 1 Month After Left-Sided Breast Cancer Radiation Therapy

PET/MRI Assessment of Acute Cardiac Inflammation 1 Month After Left-Sided Breast Cancer Radiation Therapy

Tracking the progress of inflammation with PET/MRI in a canine model of myocardial infarction

Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2022: positron emission tomography, computed tomography, and magnetic resonance

Contact Info

Product

Resources

About