Simultaneous Mucosal and Small Bowel Angioedema Due to Captopril

Smoger, Steven H.; Sayed, M.A.

doi:10.1097/00007611-199811000-00015

Cited by 16 publications

(21 citation statements)

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“…9,10,14,15 Isolated visceral angioedema has been described secondary to C1 esterase deficiency 9-13 and ACE inhibitors. [1][2][3][4][5][6][7][8] Endoscopic descriptions of the intestine during an attack of angioedema are rare, possibly due to the rapid resolution of the abnormalities. Koruth et al 11 described the colonoscopic finding of massive mucosal colonic edema in a patient with hereditary angioedema.…”

Section: Discussionmentioning

confidence: 99%

Calcium Channel Blocker-associated Small Bowel Angioedema

Turcu¹,

White

Kulaga³

et al. 2009

Journal of Clinical Gastroenterology

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Section: Discussionmentioning

confidence: 99%

Calcium Channel Blocker-associated Small Bowel Angioedema

Turcu¹,

White

Kulaga³

et al. 2009

Journal of Clinical Gastroenterology

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“…Acute pancreatitis [1] and diarrhoea [2][3][4][5] are the two major gastrointestinal adverse effects of ACE inhibitors. Diarrhoea might be associated with eosinophilic gastroenteritis [6] and angioedema of the small bowel [7][8][9][10][11]. There is a variety of causes for angioedema including hereditary angioedema, acquired C1-esterase inhibitor deficiency and reactions to contrast dyes, blood products and drugs.…”

Section: Discussionmentioning

confidence: 99%

“…ACE inhibitor-induced small bowel angioedema most frequently presents with severe abdominal pain and ascites and small bowel edema. It has been described following medication with lisinopril, enalapril, perindopril and captopril [7][8][9][10][11]. While the time between the start of the ACE inhibitor medication and the first manifestation of abdominal symptoms might vary symptoms spontaneously resolve within 24-48 h after onset.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic Visualization of Angiotensin-converting Enzyme Inhibitor-induced Small Bowel Angioedema as a Cause of Relapsing Abdominal Pain using Double-balloon Enteroscopy

2008

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A 40-year-old woman presented with 3 episodes of abdominal pain. Abdominal ultrasound demonstrated edema of the small bowel. Double-balloon enteroscopy (DBE) showed diffuse swelling of the small intestine, petechial bleeding in the jejunum, and focal inflammation of the ileum. Pain and small bowel edema resolved spontaneously within 48 h during each episode. Review of the patient's history revealed that she had been started on enalapril for arterial hypertension two weeks before her first episode. Angiotensin-converting enzyme (ACE) inhibitor-associated angioedema of the small bowel was suspected and enalapril was discontinued. The patient remained symptom-free after discontinuing the ACE inhibitor. Review of the literature reveals only 11 similar cases with this case being the first to apply DBE to visualize macroscopic alterations to the small intestine. Angioedema of the intestine is a diagnostic pitfall frequently leading to prolonged diagnostic procedures and is a potential cause for abdominal pain in patients taking ACE inhibitors.

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“…Although ACE inhibitors are generally safe, they are known to cause angioedema involving the face, neck, tongue, pharynx, and even gastrointestinal tract [5][6][7][8]. Angioedema can be extensive enough to cause acute airway obstruction and even death [9].…”

Section: Introductionmentioning

confidence: 99%

Angiotensin converting enzyme inhibitor-induced angioedema: a report of two cases

Assadi

Wang

Lawless

et al. 1999

Pediatric Nephrology

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Angioedema is a rare but potentially fatal side effect of angiotensin converting enzyme (ACE) inhibitors. We report for the first time, two children with systemic lupus erythematosus who developed acute angioedema after the long-term use of enalapril. Prompt recognition and appropriate management of ACE-induced angioedema prevented life-threatening complications. This report highlights the potential risks of angioedema associated with the use of ACE inhibitors in children. Patients should be advised to seek medical treatment immediately if they experience swelling of the face, neck, or tongue, and especially if they have trouble breathing, speaking, or swallowing.

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Simultaneous Mucosal and Small Bowel Angioedema Due to Captopril

Cited by 16 publications

References 0 publications

Calcium Channel Blocker-associated Small Bowel Angioedema

Calcium Channel Blocker-associated Small Bowel Angioedema

Endoscopic Visualization of Angiotensin-converting Enzyme Inhibitor-induced Small Bowel Angioedema as a Cause of Relapsing Abdominal Pain using Double-balloon Enteroscopy

Angiotensin converting enzyme inhibitor-induced angioedema: a report of two cases

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