Simultaneous Multiple Immunoassays in a Compact Disc–Shaped Microfluidic Device Based on Centrifugal Force

Honda, N.; Lindberg, Ulrika; Andersson, P.; Hoffmann, Stephan; Takei, Hiroyuki

doi:10.1373/clinchem.2005.053348

Cited by 145 publications

(95 citation statements)

References 13 publications

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“…A number of studies have shown the possibility of being able to modify the exposed metal layer using readily available office printers [7,10,76] or similar techniques [73] or chemically to form self-assemble monolayers [32] of for the addition for functional groups [33]. Beyond the scope of this review, reports have shown the possibility of utilising CDs and DVDs for both sample preparation as well as quantification using approaches such as surface plasma resonance [89], centrifugal microfluidics or so called 'lab-on-a-disc' devices [90][91][92][93][94][95], DNA microarrays [96]. Their application in the exploitation of solar energy [97] and the development of batteries [98] has also been reported.…”

Section: Discussionmentioning

confidence: 99%

Cheap and disposable gold and silver electrodes: Trends in the application of compact discs and digital versatile discs for electroanalytical chemistry

Honeychurch

2017

TrAC Trends in Analytical Chemistry

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Highlights Compact discs and digital versatile discs can be readily used to give cheap reproducible Au and Ag electrodes. Their fabrication and use in electroanalytical chemistry is reviewed. Applications, performance characteristics and construction details are reviewed. AbstractIncreasingly more reports have focused on the use of digital versatile discs (DVDs) and compact discs (CDs) for the fabrication of electrodes. The majority of discs use Al to reflect the laser. However, a notable percentage utilise Au or Ag. This layer can be mechanically or chemically exposed allowing for the economic fabrication of 2 otherwise expensive Ag and Au electrodes. Cleaning steps are not required due to the layer's mirror like surface. Mass production of these discs means they are available, reproducible and disposable. Modifications can be made by laser, inkjet printing, etching or xurography. Self-assembled monolayers and the attachment of functional groups can also be made. This review (98 references and 5 figures) is divided into four sections. The first describes the development of these electrodes and their fabrication and modification. The next three sections focused on applications for the determination of metal ions, biomedical and environmental analysis.

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Section: Discussionmentioning

confidence: 99%

Cheap and disposable gold and silver electrodes: Trends in the application of compact discs and digital versatile discs for electroanalytical chemistry

Honeychurch

2017

TrAC Trends in Analytical Chemistry

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“…Here, the application of microchip technology offers the opportunity to reduce the costs associated with clinical grade reagents, while ensuring faster, accurate, and time-resolved analysis Chin et al, 2011;Eyer et al, 2013;Kim and Paczesny, 2013). A number of different ELISA-lab-on-a-chip (ELISA-LoC) systems with comparable sensitivities were recently designed, fabricated, and tested for immunological detection (Honda and Lindberg, 2005;Sista et al, 2008;Lee et al, 2009;Kim et al, 2011;Miller and Ng, 2011). A digital microfluidic (DMF) device by Miller and Ng (2011) was applied to a heterogeneous sandwich immunoassay ( Figure 5A).…”

Section: Immunoassay-on-chip For Quality Control Applicationsmentioning

confidence: 99%

Automated, Miniaturized, and Integrated Quality Control-on-Chip (QC-on-a-Chip) for Cell-Based Cancer Therapy Applications

et al. 2015

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The combination of microfabrication-based technologies with cell biology has laid the foundation for the development of advanced in vitro diagnostic systems capable of evaluating cell cultures under defined, reproducible, and standardizable measurement conditions. In the present review, we describe recent lab-on-a-chip developments for cell analysis and how these methodologies could improve standard quality control in the field of manufacturing cell-based vaccines for clinical purposes. We highlight in particular the regulatory requirements for advanced cell therapy applications using as an example dendritic cell-based cancer vaccines to describe the tangible advantages of microfluidic devices that overcome most of the challenges associated with automation, miniaturization, and integration of cell-based assays. As its main advantage, lab-on-a-chip (LoC) technology allows for precise regulation of culturing conditions, while simultaneously monitoring cell relevant parameters using embedded sensory systems. State-of-the-art lab-on-a-chip platforms for in vitro assessment of cell cultures and their potential future applications for cell-based strategies for cancer immunotherapy are discussed in the present review.

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“…centrifugal devices (CD)), the circulation of the fluid relies on the hydrophilicity of the surface substrate. The sequential release of the fluids depends on the centrifugal and capillary forces; when spinning the device, the centrifugal force overcomes the capillary force in the valves [150,151]. An advantage of the CD is that centrifugal pumping eliminates the need for pumps requiring large power supplies to drive the fluids.…”

Section: Miniaturisation Of Immunosensorsmentioning

confidence: 99%

Trends and Perspectives in Immunosensors

2012

Antibodies Applications and New Developments

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Immunosensors are devices that comprise both a biomolecular recognition system, such as an antibody and its corresponding antigen, and a transducer to translate the high affinity and specific binding event into a physical signal.Antibodies are produced by an immunological response to the presence of a foreign substance called an antigen. Antibodies may be immobilised onto a variety of platforms including bulk planar surfaces and nanoparticles by either covalent or adsorption strategies. Different interfaces between the bio-components and the detector are available to monitor in 'real-time' the signal generated by biological interactions. The transducers detect, for example, the change in electron transfer, absorbance, fluorescence, refractive index, mass change or heat transfer as the antibody binds to the antigen of interest. Such analytical devices have allowed a wide range of analytes to be identified and quantified such as pathogens, toxins, environmental food contaminants and disease biomarkers.The demand for sensitive, rapid, 'on-site' techniques has taken advantage of the latest advances in microfluidics and nanotechnology. This chapter will highlight current trends in immobilisation, micro/nano-fluidics/ and transducers utilised. A number of examples outlining the exploitation of these elements in immunosensors and their successful applications will be described.

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Simultaneous Multiple Immunoassays in a Compact Disc–Shaped Microfluidic Device Based on Centrifugal Force

Cited by 145 publications

References 13 publications

Cheap and disposable gold and silver electrodes: Trends in the application of compact discs and digital versatile discs for electroanalytical chemistry

Cheap and disposable gold and silver electrodes: Trends in the application of compact discs and digital versatile discs for electroanalytical chemistry

Automated, Miniaturized, and Integrated Quality Control-on-Chip (QC-on-a-Chip) for Cell-Based Cancer Therapy Applications

Trends and Perspectives in Immunosensors

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