Simultaneous near-infrared diffusive light and ultrasound imaging

Chen, Nanguang; Guo, Puyun; Yan, Shikui; Piao, Daqing; Zhu, Quing

doi:10.1364/ao.40.006367

Cited by 86 publications

(70 citation statements)

References 31 publications

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“…Our new imager has been calibrated using 0.52% Intralipid solution that has optical properties similar to human breasts. By use of a calibration method described in our previous publication [14], relative gains and phase delays can be obtained as well as corrected amplitudes and phases. Shown in Fig.…”

Section: Body: Multi-channel Three-wavelength Nir Imagermentioning

confidence: 99%

Monitoring Cancer Oxygenation Changes Induced by Ultrasound

Maurudis¹,

Zhu²

2004

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Section: Body: Multi-channel Three-wavelength Nir Imagermentioning

confidence: 99%

Monitoring Cancer Oxygenation Changes Induced by Ultrasound

Maurudis¹,

Zhu²

2004

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“…The amplitude and phase measured from the normal side of the breast are used to calculate the background absorption μ a and reduced scattering coefficient μ s ′ . 4 In our two-step image reconstruction, we first segment tissue volume into two regions, L and B, that contain a lesion as measured from coregistered ultrasound images and background tissue, respectively. We use the Born approximation to relate the scattered field U sc ′(r si , r di , ω) measured at source-detector pair i to absorption variations Δμ a (r′) in each volume element of two regions within the sample, where r si and r di are the source and detector positions, respectively.…”

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confidence: 99%

Imaging tumor angiogenesis by use of combined near-infrared diffusive light and ultrasound

2003

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A novel two-step reconstruction scheme using a combined near-infrared and ultrasound technique and its utility in imaging distributions of optical absorption and hemoglobin concentration of breast lesions are demonstrated. In the first-step image reconstruction, the entire tissue volume is segmented based on initial coregistered ultrasound measurements into lesion and background regions. Reconstruction is performed by use of a finer grid for lesion region and a coarse grid for the background tissue. As a result, the total number of voxels with unknown absorption can be maintained on the same order of total measurements, and the matrix with unknown total absorption distribution is appropriately scaled for inversion. In the second step, image reconstruction is refined by optimization of lesion parameters measured from ultrasound images. It is shown that detailed distributions of wavelength-dependent absorption and hemoglobin concentration of breast carcinoma can be obtained with the new reconstruction scheme.Tumor blood volume and microvascular density are parameters that are anatomically and functionally associated with tumor angiogenesis. During the past decade, modeling of light propagation in the near-infrared (NIR) region, combined with advancements of light source and detectors, has improved diffused light measurements and made possible the application of tomographic techniques for characterizing and imaging tumor angiogenesis. 1,2 However, the NIR technique has not been widely used in clinics, and the fundamental problem of intense light scattering remains. As a result, diffusive light probes a widespread region instead of providing information along a straight line, and tomographic image reconstruction is, in general, underdetermined and ill-posed. Zhu et al. 3 and Chen et al. 4 demonstrated a combined imaging technique, using a priori lesion structure information provided by coregistered ultrasound images to assist NIR imaging reconstruction in phantom studies. 3,4 As a result, the NIR image reconstruction is well defined and less sensitive to noise. In this Letter we report on our novel two-step image reconstruction scheme that uses the combined approach and demonstrate its utility in imaging tumor absorption and hemoglobin distributions. It is shown that detailed heterogeneous distributions of wavelength-dependent optical absorption and hemoglobin concentration of a breast carcinoma can be obtained. To the best of our knowledge, such detailed distributions have not been reported in the literature.

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“…In order to successfully reconstruct a lesion size and location in three dimensions, a priori information from another imaging modality (e.g. ultrasound) was required [65][66][67][68][69][70].…”

Section: Discussionmentioning

confidence: 99%

“…Several versions of a multi-modal hand-held device (Devices #10a, #10b, #11, Table 3.1) have been developed at the University of Connecticut [62][63][64][65][66][67][68][69][70][71] which combine NIR optical imaging and ultrasound into a single hand-held device. The optical information using multiple wavelengths can better determine the tumor malignancy [67,69] and the ultrasound component provides a priori information which enables tumor localization by 3D…”

Section: Tumor Localization and Characterizationmentioning

confidence: 99%

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Clinical Translation of a Novel Hand-held Optical Imager for Breast Cancer Diagnosis

Erickson¹

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Simultaneous near-infrared diffusive light and ultrasound imaging

Cited by 86 publications

References 31 publications

Monitoring Cancer Oxygenation Changes Induced by Ultrasound

Monitoring Cancer Oxygenation Changes Induced by Ultrasound

Imaging tumor angiogenesis by use of combined near-infrared diffusive light and ultrasound

Clinical Translation of a Novel Hand-held Optical Imager for Breast Cancer Diagnosis

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