Simultaneous Occurrence of Ductal Carcinoma<i>In Situ</i>within Juvenile Fibroadenoma in Both Breasts: A Brief Case Report

Kwon, Mi Jung; Park, Hye-Rim; Seo, Jinwon; Kim, Dong Hoon; Jung, K.S.; Lim, Young Ah; Kim, Lee Su; Bae, Hyo-Sang; Park, In Ae; Min, Soo Kee

doi:10.4132/koreanjpathol.2014.48.2.164

Cited by 2 publications

(3 citation statements)

References 3 publications

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“…The risk of malignant change persisted even 20 years after the diagnosis of fibroadenoma. Other studies also provide strong evidence that fibroadenoma with hyperplasia is associated with an increased risk of breast cancer [19,20].…”

Section: Discussionmentioning

confidence: 99%

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Incidental Detection of Carcinoma in Situ in Fibroadenoma of Breast in a Young Woman: A Rare Finding

Kairanna

Singh

2019

Asian J Pharm Clin Res

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Fibroadenoma is the most common benign tumor of the breast in young females. Breast cancer arising within a fibroadenoma is a rare phenomenon. The incidence of carcinoma within a fibroadenoma is reported to be between 0.1% and 0.3% in a screened population, with a peak age of occurrence between the 4th and 5th decade. We present a case of 29-year-old female with ductal carcinoma in situ in a background of fibroadenoma. There is a low percentage of fibroadenomas harboring carcinoma; however, all breast lumps should be seriously managed; extirpation and histological examination is recommended.

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Section: Discussionmentioning

confidence: 99%

“…• Intraductal carcinoma focus is also seen in the adjacent breast • Intraductal proliferative lesions within fibroadenoma show cancer characteristic findings, for example, epithelial necrosis [20].…”

Section: Discussionmentioning

confidence: 99%

Incidental Detection of Carcinoma in Situ in Fibroadenoma of Breast in a Young Woman: A Rare Finding

Kairanna

Singh

2019

Asian J Pharm Clin Res

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“…The diagnostic criteria of DCIS within fibroadenomas require showing at least one of the following findings: (a) intraductal carcinoma focus, seen in the adjacent breast tissue, or (b) intraductal proliferative lesions within fibroadenomas show cancer-characteristic findings, e.g., epithelial necrosis [7].…”

Section: Discussionmentioning

confidence: 99%

Incidental Detection of Carcinoma In-situ in Fibroadenoma of the Breast in a Young Woman: A Rare Finding

Tiwari¹,

Singh²,

Varshney³

et al. 2018

Cureus

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Fibroadenoma, being a very common benign tumor of the breast in young females, does not pose any threat and, thus, can be treated with lumpectomy. Breast cancer arising within a fibroadenoma is a rare phenomenon, but detecting these neoplasms is of utmost importance for complete treatment and follow-up. These lesions are an incidental finding in a lumpectomy specimen done for fibroadenoma breast. A 28-year-old female presented with multiple bilateral lumps for eight years. The lumps were mobile, non-tender, and slowly growing, with no nipple discharge, no axillary lymphadenopathy, and no family history. The diagnosis of a benign lesion suggestive of fibroadenoma was given on ultrasonography (USG) and fine-needle aspiration cytology (FNAC). The patient underwent lumpectomy and the excised tissues were subjected to histopathological examination. Grossly, multiple, well-circumscribed, encapsulated masses, with the largest measuring 4x2.5x2 cm were noted. All masses showed homogenous grey-white areas with slit-like spaces. On microscopy, predominant areas were consistent with fibroadenoma, with few foci showing the features of ductal carcinoma in situ (DCIS) with nests of cells having pleomorphic nuclei, prominent nucleoli with atypical mitosis, a cribriform pattern, and comedo necrosis. This highlights the rare association of fibroadenoma and carcinoma in situ, thus, a careful and extensive sampling of the tissue is required to prevent the false negative diagnosis by pathologists.

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Simultaneous Occurrence of Ductal CarcinomaIn Situwithin Juvenile Fibroadenoma in Both Breasts: A Brief Case Report

Cited by 2 publications

References 3 publications

Incidental Detection of Carcinoma in Situ in Fibroadenoma of Breast in a Young Woman: A Rare Finding

Incidental Detection of Carcinoma in Situ in Fibroadenoma of Breast in a Young Woman: A Rare Finding

Incidental Detection of Carcinoma In-situ in Fibroadenoma of the Breast in a Young Woman: A Rare Finding

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