Simultaneous osteosarcoma and renal cell carcinoma with <i>BRCA1</i> mutation in a young male adult with prior oligodendroglioma

Dhir, Aditi; Li, Rong; Li, Geling; Dean, Jane H.; Robin, Nathaniel H.; Alva, Elizabeth

doi:10.1002/pbc.28116

Cited by 3 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aberrant activation of oncogenes (eg, COPS3 , PIK3CA , CARD11 , MYC ) and inactivation of tumour suppressor genes (eg, TP53 , RB1 , ATRX , DLG2 , BRCA1 / 2 ) by somatic mutations and epigenetic mechanisms play a pivotal pathogenic role in osteosarcoma 26‐37 . Aside from alterations in these protein‐coding genes, it has now been realized that dysregulation of non‐coding RNAs (ncRNAs), including microRNAs (miRNAs), long non‐coding RNAs (lncRNAs) and the recently discovered circular RNAs (circRNAs), is crucial to the initiation and progression of osteosarcoma 2,38‐46 .…”

Section: Introductionmentioning

confidence: 99%

“…Aberrant activation of oncogenes (eg, COPS3, PIK3CA, CARD11, MYC) and inactivation of tumour suppressor genes (eg, TP53, RB1, ATRX, DLG2, BRCA1/2) by somatic mutations and epigenetic mechanisms play a pivotal pathogenic role in osteosarcoma. [26][27][28][29][30][31][32][33][34][35][36][37] Aside from alterations in these protein-coding genes, it has now been realized that dysregulation of non-coding RNAs (ncRNAs), including microR-NAs (miRNAs), long non-coding RNAs (lncRNAs) and the recently discovered circular RNAs (circRNAs), is crucial to the initiation and progression of osteosarcoma. 2,[38][39][40][41][42][43][44][45][46] CircRNAs are single-stranded RNAs that form covalently closed loops and function as an important regulatory element of the genome through multiple machineries, including transcription regulation, modulation of alternative splicing, sponging of miRNAs and direct interactions with RNA-binding proteins.…”

mentioning

confidence: 99%

See 1 more Smart Citation

An update on the roles of circular RNAs in osteosarcoma

Zheng

et al. 2020

Cell Proliferation

View full text Add to dashboard Cite

Osteosarcoma, a neoplasm thought to be derived from the bone-forming mesenchymal stem cells, is the most common primary bone malignancy, predominantly involving metaphyseal regions of the long bones (eg, proximal end of tibia or humerus and distal end of femur) which are the most rapidly growing parts of the skeleton in children and adolescents. 1-5 The incidence of osteosarcoma follows a bimodal age distribution with ages between 10 and 30 primarily affected. 6-10 The second peak appears in the elderly in which osteosarcoma very often comes as a later cancer secondary to radiation exposure or is associated with Paget disease (a disorder of bone remodelling resulting in structural weakening). 11-16 With the advent of neoadjuvant and adjuvant chemotherapy with cisplatin, doxorubicin and high-dose methotrexate and the advances in surgery, the 5-year survival rate of patients with osteosarcoma has improved from ~20% before the 1980s to currently ~ 70%. 17-22 Nevertheless, half of the patients still do not survive for longer than 10 year. 23-25 Thus, it is

show abstract

“…Aberrant activation of oncogenes (eg, COPS3 , PIK3CA , CARD11 , MYC ) and inactivation of tumour suppressor genes (eg, TP53 , RB1 , ATRX , DLG2 , BRCA1 / 2 ) by somatic mutations and epigenetic mechanisms play a pivotal pathogenic role in osteosarcoma 26‐37 . Aside from alterations in these protein‐coding genes, it has now been realized that dysregulation of non‐coding RNAs (ncRNAs), including microRNAs (miRNAs), long non‐coding RNAs (lncRNAs) and the recently discovered circular RNAs (circRNAs), is crucial to the initiation and progression of osteosarcoma 2,38‐46 .…”

Section: Introductionmentioning

confidence: 99%

“…Aberrant activation of oncogenes (eg, COPS3, PIK3CA, CARD11, MYC) and inactivation of tumour suppressor genes (eg, TP53, RB1, ATRX, DLG2, BRCA1/2) by somatic mutations and epigenetic mechanisms play a pivotal pathogenic role in osteosarcoma. [26][27][28][29][30][31][32][33][34][35][36][37] Aside from alterations in these protein-coding genes, it has now been realized that dysregulation of non-coding RNAs (ncRNAs), including microR-NAs (miRNAs), long non-coding RNAs (lncRNAs) and the recently discovered circular RNAs (circRNAs), is crucial to the initiation and progression of osteosarcoma. 2,[38][39][40][41][42][43][44][45][46] CircRNAs are single-stranded RNAs that form covalently closed loops and function as an important regulatory element of the genome through multiple machineries, including transcription regulation, modulation of alternative splicing, sponging of miRNAs and direct interactions with RNA-binding proteins.…”

mentioning

confidence: 99%