Simultaneous qualitative and quantitative determination of phenolic compounds in Aloe barbadensis Mill by liquid chromatography–mass spectrometry-ion trap-time-of-flight and high performance liquid chromatography-diode array detector

Wu, Xiaofang; Ding, Wen-Jing; Zhong, Jia-Sheng; Wan, Jinzhi; Xie, Zenghong

doi:10.1016/j.jpba.2013.02.034

Cited by 59 publications

(63 citation statements)

References 34 publications

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“…This splitting through the sugar moiety can be considered a characteristic fragmentation pattern for C-glycosides [19,20]. The loss of glucose unit (162 Da) or rutinose unit (308 Da) has also been observed in some C-glycosyl flavonoids, such as flavosativaside and vitexin 2 -rhamnoside [21][22][23].…”

Section: Hplc-qtof-ms-based Analyte Identificationmentioning

confidence: 99%

Identification and quantification of phenolic compounds in Vitex negundo L. var. cannabifolia (Siebold et Zucc.) Hand.-Mazz. using liquid chromatography combined with quadrupole time-of-flight and triple quadrupole mass spectrometers

Huang

Zhang

et al. 2015

Journal of Pharmaceutical and Biomedical Analysis

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Section: Hplc-qtof-ms-based Analyte Identificationmentioning

confidence: 99%

Identification and quantification of phenolic compounds in Vitex negundo L. var. cannabifolia (Siebold et Zucc.) Hand.-Mazz. using liquid chromatography combined with quadrupole time-of-flight and triple quadrupole mass spectrometers

Huang

Zhang

et al. 2015

Journal of Pharmaceutical and Biomedical Analysis

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“…Aloe-emodin, an anthraquinone constituent in Aloe barbadensis MILLER, Rheum palmatum L., Cassia obtusifolia L. and C. angustifolia VAHL, etc. (Peng et al, 2014;Shia et al, 2009a;Wu et al, 2013;Xu et al, 2012), has shown a wide range of beneficial activities including anticancer Guo et al, 2007;Mulakayala et al, 2013), antivirus (Li et al, 2014), anti-inflammation Park et al, 2009) and antiangiogenesis (Cardenas et al, 2006). However, most of the bioactivities of aloe-emodin were demonstrated by in vitro studies.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the pharmacokinetics and metabolism of aloe‐emodin following intravenous and oral administrations in rats

Shia

Lin

et al. 2016

Biomedical Chromatography

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Aloe-emodin, a natural polyphenolic anthraquinone, has shown various beneficial bioactivities in vitro. The aim of this study was to investigate the pharmacokinetics and metabolism of aloe-emodin. Aloe-emodin was intravenously and orally administered to rats. The concentrations of aloe-emodin and rhein, a metabolite of aloe-emodin, were determined by HPLC method prior to and after hydrolysis with β-glucuronidase and sulfatase/β-glucuronidase. The results showed that the systemic exposures of aloe-emodin and its metabolites were ranked as aloe-emodin glucuronides (G) > rhein sulfates (S) > aloe-emodin > rhein and rhein G when aloe-emodin was given intravenously. In contrast, when aloe-emodin was administered orally, the parent form of aloe-emodin was not absorbed per se, and the systemic exposures of its metabolites were ranked as aloe-emodin G > rhein G > rhein. In conclusion, the metabolites of aloe-emodin are more important than the parent form for the bioactivities in vivo. Copyright © 2016 John Wiley & Sons, Ltd.

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“…The sulfonyl substituted chromones, thiazolidinedione hybrids display a potent role in opening potassium channels on ATP compared with the other pyridonechromenes . Gas chromatography‐mass spectrometry (GC‐MS), nuclear magnetic resonance (NMR), and high‐resolution mass spectrometry (HRMS) coupled with other separation techniques have been used for the quantification of substituted 3‐chromones in drugs . Among this, HPLC‐MS is highly recommended due to its high throughput analysis ability and the process does not need further derivatization.…”

Section: Introductionmentioning

confidence: 99%

Gas phase reaction between chromones and solvent in an electrospray ionization source

et al. 2018

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Chromones were measured by using electrospray ionization mass spectrometry in negative mode. Interestingly, in addition to the deprotonated ion ([M − H]−), unexpected [M + 17]− and [M + 31]− ions were observed in high intensity when water and methanol were used as the solvent. Chromones with different substitutes were tested. Compared with the deprotonated ion, [M + 17]− and [M + 31]− ions were observed with higher abundances when the C‐3 site of chromones was substituted by electron withdrawing groups. Based on high performance liquid chromatography‐mass spectrometry (LC‐MS), deuterium‐labeling and collisional‐induced dissociation experiments, a covalent gas‐phase nucleophilic addition reaction between chromone and water, and the formation of a noncovalent complex between chromone and methanol were proposed as the mechanism for the observed [M + 17]− and [M + 31]− ions, respectively. Understanding and using these unique gas phase reactions can avoid misannotation when analyzing chromones and their metabolites.

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Simultaneous qualitative and quantitative determination of phenolic compounds in Aloe barbadensis Mill by liquid chromatography–mass spectrometry-ion trap-time-of-flight and high performance liquid chromatography-diode array detector

Cited by 59 publications

References 34 publications

Identification and quantification of phenolic compounds in Vitex negundo L. var. cannabifolia (Siebold et Zucc.) Hand.-Mazz. using liquid chromatography combined with quadrupole time-of-flight and triple quadrupole mass spectrometers

Identification and quantification of phenolic compounds in Vitex negundo L. var. cannabifolia (Siebold et Zucc.) Hand.-Mazz. using liquid chromatography combined with quadrupole time-of-flight and triple quadrupole mass spectrometers

Analysis of the pharmacokinetics and metabolism of aloe‐emodin following intravenous and oral administrations in rats

Gas phase reaction between chromones and solvent in an electrospray ionization source

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