Simultaneous quantification of chrysophanol and physcion in rat plasma by ultra fast liquid chromatography–tandem mass spectrometry and application of the technique to comparative pharmacokinetic studies of Radix et Rhei Rhizoma extract alone and Dahuang Fuzi Decoction

Liu, Xiao; Li, Huan; Wu, Li; Xing, Jiangwa; Poh, Yanhong; Cai, Hao; Cai, Bao Chang

doi:10.1016/j.jchromb.2014.11.025

Cited by 20 publications

(16 citation statements)

References 17 publications

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“…b–b3). Based on a suitable dosage and safety of the anthraquinones, 10 μM was selected as the subsequent inhibitor concentration at which no apparent cytotoxicity was observed (Li et al ; Liu, et al, ; Wang, et al, ). The inhibition rates for crosslinked AGEs formation determined at this concentration were 46.48%, 66.38%, and 57.32%, respectively.…”

Section: Resultsmentioning

confidence: 99%

Main anthraquinone components in Aloe vera and their inhibitory effects on the formation of advanced glycation end-products

Kang

Zhao

et al. 2016

Journal of Food Processing and Preservation

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Food heating process causes increased protein glycation and the formation of advanced glycation endproducts (AGEs) which related with diabetes and ageing. Aloe vera (A. vera) extract is a potent antioxidant with established effects attributed largely to a key ingredient anthraquinone. This study investigated the inhibitory ability of the three anthraquinones from A. vera on the formation of AGEs in a heated model system at 70°C. Anthraquinones, including aloe‐emodin (AED), emodin (ED), and chrysophanol (CSN), were extracted from A. vera and analyzed by ultra‐high performance liquid chromatography‐tandem mass spectrometry. Under optimal extraction conditions, the extraction yield of the anthraquinones was 4.377 mg/g. Anthraquinones showed good inhibition toward the formation of glycation products; the inhibition rates of AED, ED, and CSN on crosslinked AGEs were 46.48%, 66.38%, and 57.32% at 10 μM concentrations. Sodium dodecyl sulfate–polyacrylamide gel electrophoresis images also proved that the anthraquinones could significantly inhibit crosslinked AGE formation in a time‐dependent manner. ED showed higher inhibitory ability than AED and CSN on the formation of Nɛ‐(carboxymethyl)lysine and crosslinked AGEs. The results indicate that the antiglycation properties of these anthraquinones are likely related to the phenolic hydroxyl groups in their structures, but this ability is not related to their antioxidant activity, which probably depends on the whole structure of the quinone. Generally, the anthraquinones in A. vera, especially ED, can effectively inhibit AGE formation and reduce protein crosslinking during food processing, even at low concentration. Practical applications The inhibitory effects of three anthraquinones extracted from Aloe vera on the formation of AGEs were investigated in a heated model system. The results indicate Aloe can be used as an effective inhibitor of glycation products in food processing, moreover, this research can be useful for finding suitable nature inhibitors of AGEs for food processing.

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Section: Resultsmentioning

confidence: 99%

Main anthraquinone components in Aloe vera and their inhibitory effects on the formation of advanced glycation end-products

Kang

Zhao

et al. 2016

Journal of Food Processing and Preservation

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“…Increased AUC, T 1/2 and T max and decreased C max and MRT compared to Radix et Rhizoma Rhei group [94] Rheum palmatum L., and Aconitum carmichaelii Debx.…”

Section: Male Sprague Dawley Ratsmentioning

confidence: 91%

“…In Quyu Qingre granules (composing of Rhizome Rhei, Semen Persicae, Fructus Cartaegi, Ramulus Cinnamomi and Radix Glycyrrhizae ), the half‐life of chrysophanol was prolonged compared to the rhubarb group . DHFZ Decoction (composed of Radix et Rhizoma Rhei, Radix Aconiti Lateralis Praeparata and Radix et RhizomaAsari ) reduced the peak time retention and C max of chrysophanol and emodin, but enhanced the therapeutic effect for acute pancreatitis and reduced toxicity . Interestingly, removing Radix et RhizomaAsari significantly increased the C max and area under the curve of emodin and chrysophanol compared to the Radix et Rhizoma Rhei group .…”

Section: Pharmacologymentioning

confidence: 99%

“…[93] DHFZ Decoction (composed of Radix et Rhizoma Rhei, Radix Aconiti Lateralis Praeparata and Radix et RhizomaAsari) reduced the peak time retention and C max of chrysophanol and emodin, but enhanced the therapeutic effect for acute pancreatitis and reduced toxicity. [94] Interestingly, removing Radix et RhizomaAsari significantly increased the C max and area under the curve of emodin and chrysophanol compared to the Radix et Rhizoma Rhei group. [95] In addition, a drug pair consisting of Radix et Rhizoma Rhei and Gardenia jasminoides Ellis could increase systemic exposure to chrysophanol and prolong retention time.…”

Section: Mouse Osteoblast Unknownmentioning

confidence: 99%

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Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics

Xie

Tang

Song

et al. 2019

Journal of Pharmacy and Pharmacology

101

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Objective Chrysophanol is a natural anthraquinone, also known as chrysophanic acid and 1,8‐dihydroxy‐3‐methyl‐anthraquinone. It has been widely used in the food and pharmaceutical fields. This review is intended to provide a comprehensive overview of the pharmacology, toxicity and pharmacokinetic researches of chrysophanol. Key finding Information on chrysophanol was collected from the Internet database PubMed, Elsevier, ResearchGate, Web of Science, Wiley Online Library and Europe PM using a combination of keywords including ‘pharmacology’, ‘toxicology’ and ‘pharmacokinetics’. The literature we collected included from January 2010 to June 2019. Chrysophanol has a wide spectrum of pharmacological effects, including anticancer, antioxidation, neuroprotection, antibacterial and antiviral, and regulating blood lipids. However, chrysophanol has obvious hepatotoxicity and nephrotoxicity, and pharmacokinetics indicate that the use of chrysophanol in combination with other drugs can reduce toxicity and enhance efficacy. Summary Chrysophanol can be used in many diseases. Future research directions include how the concentration of chrysophanol affects pharmacological effects and toxicity; the mechanism of synergy between chrysophanol and other drugs.

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“…For example, a recent study of drug compatibility demonstrated that the combination of Radix Aconiti Laterlis with Radix Glycyrrhizae resulted in signicant changes in the pharmacokinetics of aconitine, mesaconitine and hypaconitine detected in rat plasma. The feasibility of these methods have been validated, [8][9][10][11] despite the fact that they require relatively large amounts of samples for testing and complex pre-treatment methods for detection. 6 In addition to metabolism, the combination and dose of herbs may alter absorption of the medicine.…”

Section: Introductionmentioning

confidence: 99%

Determination of baicalin and ginsenoside Re in Banxia-Xiexin decoction using pharmacokinetics and icELISA analysis in mice. Effects of interaction between prescription herbs on the pharmacokinetics of compounds

Sun

Sai

et al. 2015

Anal. Methods

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Currently, little is known about how the dosage of one component of traditional Chinese medicine (TCM) alters the pharmacokinetic properties of the others in prescriptions. Banxia-Xiexin Decoction (BXD) consists of concentrated granules of seven Chinese herbs. The aim of this study was to explore how dosage variations of Pinellia ternata (Thunb.) Breit., the monarch herb in BXD, affected the pharmacokinetics of baicalin (BAL) and ginsenoside Re (GsRe) in the blood of treated mice. The decoctions containing low dose, middle dose, and high dose of Pinellia ternata were administered orally to mice, and indirect competitive enzyme-linked immunosorbent assays (icELISAs) using an anti-BAL-monoclonal antibody (MAb) and anti-GsRe-MAb were performed to determine the concentrations of BAL and GsRe in the blood of treated mice. The results showed that variations of Pinellia ternata doses altered the contents of BAL and GsRe in mouse blood. In all the groups, the BAL concentrations peaked at approximately 30 min and again at approximately 400 min, while GsRe showed more concentration peaks than BAL. The AUC 0Àt of BAL showed a linear relationship with the dose of Pinellia ternata, and the AUC 0Àt of GsRe also showed a direct relationship with the dose of Pinellia ternata. IcELISA may represent a feasible method for the study of the pharmacokinetics of TCM. Moreover, these results provide a meaningful basis for evaluation of the interactions between the components in a complex prescription on their pharmacokinetics.

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Simultaneous quantification of chrysophanol and physcion in rat plasma by ultra fast liquid chromatography–tandem mass spectrometry and application of the technique to comparative pharmacokinetic studies of Radix et Rhei Rhizoma extract alone and Dahuang Fuzi Decoction

Cited by 20 publications

References 17 publications

Main anthraquinone components in Aloe vera and their inhibitory effects on the formation of advanced glycation end-products

Main anthraquinone components in Aloe vera and their inhibitory effects on the formation of advanced glycation end-products

Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics

Determination of baicalin and ginsenoside Re in Banxia-Xiexin decoction using pharmacokinetics and icELISA analysis in mice. Effects of interaction between prescription herbs on the pharmacokinetics of compounds

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