Simultaneous quantitation of paracetamol, caffeine and propyphenazone by high-pressure liquid chromatography

Simultaneous determination of paracetamol, caffeine and propyphenazone in ternary mixtures by micellar electrokinetic capillary chromatography

“…For the simultaneous determination of these drugs in ternary mixture preparations, derivative spectrophotometry [18,19] single flow-through UV multiparameter sensor [20] and HPLC [18,21] Capillary electrokinetic techniques such as capillary zone electrophoresis (CZE) and micellar electrokinetic capillary chromatography (MEKC) have become popular techniques for the analysis of drug mixtures [22][23][24]. In MEKC, addition of micelles in the buffer solution, where the electrophoretic process takes place, allows the determination of neutral and charged analytes in a single injection [25].…”

Determination of paracetamol: Historical evolution

“…In neonates, the volume of blood taken is limited by ethical considerations and thus a method requiring only small volumes of blood is desirable. The use of a collection card similar to the Guthrie paper card used for the sampling of small volumes Caffeine, propyphenazone Reversed-phase HPLC Mobile phase is a linear water-methanol gradient [260] Codeine phosphate, sodium benzoate…”

Reversed‐phase capillary electrochromatography for the simultaneous determination of acetylsalicylic acid, paracetamol, and caffeine in analgesic tablets

“…Different methods have been reported for the simultaneous assay of ASA, PAR, and CAF, including spectrophotometry [2], second-derivative spectrophotometry [3], planar chromatography [4][5][6], infrared (IR) spectroscopy [7], capillary electrophoresis (CE) [8][9][10], and high-performance liquid chromatography [11][12][13][14][15]. Among the CE techniques employed for the analysis of ASA, PAR, and CAF, interesting results were obtained using capillary electrochromatography (CEC) coupled with nuclear magnetic resonance (NMR) [16], however, the analytical method is very expensive and requires experience in the field.…”