Simultaneous quantitative analysis of 39 common toxicological drugs for increased efficiency in an ante- and postmortem laboratory

Mata, Dani C.; Davis, John F.

doi:10.1016/j.forsciint.2022.111246

Cited by 10 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fentanyl analogs, including acetylfentanyl and carfentanil, have been previously reported in driving cases [24,25] In addition to the increased fentanyl prevalence in casework, the average, median, and maximum blood concentrations increased in the three regions covered in this study. A similar trend has been observed in New Hampshire, Kansas, and Florida [9] and previously documented in Orange County [10]. In 2001, Winek cited therapeutic fentanyl blood concentrations between 1 and 10 ng/ mL [26], whereas Baselt referenced average fatal blood concentrations at 8.3 ng/mL (range = 3.0-29 ng/mL) [27].…”

Section: Discussionsupporting

confidence: 71%

“…The blood LOD was 0.5 ng/mL for fentanyl and 1.25 ng/mL for norfentanyl. Any fentanyl case identified by LC-QTOF was quantitated by LC-MS/MS (fentanyl LOQ of 1 ng/ mL) in a method that was quantitatively validated along with 38 other drugs [10]. LC-MS/MS analysis was performed on a Waters Aquity ultra-performance LC coupled to a Waters XeVo TQ-S triple quadrupole mass spectrometer system.…”

Section: Orange County Crime Laboratory (Occl)mentioning

confidence: 99%

“…Mata and Davis described a driver with greater than 300 ng/mL of fentanyl in his blood after being stopped for erratic driving [10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The impact of fentanyl on DUIDs and traffic fatalities: Blood and oral fluid data

Harper

Mata²,

Lee

2023

Journal of Forensic Sciences

Self Cite

View full text Add to dashboard Cite

Fentanyl has emerged as the most prolific drug in the ongoing opioid epidemic and has greatly impacted traffic safety in recent years. This study aimed to evaluate fentanyl prevalence and concentrations in blood and oral fluid in driving under the influence of drugs (DUID) cases in three different regions (i.e., Alabama, Orange County, CA, and Houston, TX) from 2017 to 2022. Furthermore, traffic fatalities were evaluated for Alabama and Orange County, CA. Fentanyl positivity in DUID and traffic fatalities increased for most years in this study. In Alabama, the prevalence of fentanyl DUID cases increased 4‐fold in 2022 compared to 2017. Orange County's increase from 2017 to 2022 was 14‐fold. In Houston, the increase was approximately 2‐fold from 2019 to 2022. The greatest increase for all laboratories coincided with the start of the COVID‐19 pandemic. In 2022, the median fentanyl DUID blood concentrations were 4.7, 11, and 4.7 ng/mL in Alabama, Orange County, and Houston, respectively. Most fentanyl cases were polydrug cases (≥90%). Methamphetamine, THC, and alprazolam were the most frequently detected drugs in combination with fentanyl. Alabama has collected oral fluid and blood in DUID cases since 2018. The detection of fentanyl in oral fluid was comparable to blood. However, 59% and 8.7% of fentanyl‐positive cases had concentrations of >20 ng/mL in oral fluid and blood, respectively. Therefore, oral fluid as an alternative or supplemental specimen to blood is an attractive approach for fentanyl in DUID cases. This study contributes to understanding recent fentanyl trends and their impact on traffic safety.

show abstract

Section: Discussionsupporting

confidence: 71%

Section: Orange County Crime Laboratory (Occl)mentioning

confidence: 99%

See 1 more Smart Citation

The impact of fentanyl on DUIDs and traffic fatalities: Blood and oral fluid data

Harper

Mata²,

Lee

2023

Journal of Forensic Sciences

Self Cite

View full text Add to dashboard Cite

show abstract

“…Regression parameter of area and linear through zero type without weighting. The method was validated following the ANSI-ASB Method Validation for Forensic Toxicology Standards at an LOD of 2 and 10 ng/mL for 7-hydroxymitragynine and mitragynine, respectively (6, 7). Minimal ion suppression and enhancement was observed, and no matrix or drug interferences were detected, including paynantheine, speciogynine, speciociliatine, and mitraphylline (Cayman Chemical, Ann Arbor, MI).…”

Section: Methodsmentioning

confidence: 99%

“…Calibration curve for mitragynine was from 10 to 640 ng/mL with quality control standards at 30 and 300 ng/mL weighted with a quadratic 1/x 2 , with no forcing through the origin. Quantitation method was previously validated for blood, urine, and tissue following ANSI-ASB guidelines (6, 7). Method validation showed no matrix interferences or drug interferences, no significant ion suppression or enhancement, and bias and precision showed to be within 20% of every matrix except for brain tissue.…”

Section: Methodsmentioning

confidence: 99%

Postmortem Mitragynine Distribution in a Single Drug Fatality Case

Mata¹,

Chang²

2023

Academic Forensic Pathology

Self Cite

View full text Add to dashboard Cite

A 32-year-old Caucasian male was found unconscious at his sober-living home and pronounced dead after transportation to the emergency room. The decedent had a documented history of substance-use disorder and past suicide attempts, but according to his family, he was sober for the past year. Significant autopsy findings were cardiomegaly, hepatomegaly, congested lungs, cerebral edema, and obesity. The toxicology examination of blood and tissues using liquid chromatography tandem mass spectrometry detected only mitragynine in the central blood (7.5 mg/L), peripheral blood (3.3 mg/L), liver (42.2 mg/kg), and gastric contents (33.1 mg). The qualitative identification of 7-hydroxymitragynine was performed only on the central blood. The pathologist ruled the cause of death acute mitragynine intoxication combined with cardiomegaly with left ventricular hypertrophy, with severe hepatomegaly and obesity listed as other significant conditions. The mode, or manner, of death was determined to be an accidental overdose. To the authors’ knowledge, this is the first reported case where mitragynine was the only drug detected. This case study will contribute to the understanding of mitragynine-only death investigation and provide valuable toxicology information for medical examiners and pathologists.

show abstract

Multiple drugs

2022

Reactions Weekly

View full text Add to dashboard Cite

Simultaneous quantitative analysis of 39 common toxicological drugs for increased efficiency in an ante- and postmortem laboratory

Cited by 10 publications

References 14 publications

The impact of fentanyl on DUIDs and traffic fatalities: Blood and oral fluid data

The impact of fentanyl on DUIDs and traffic fatalities: Blood and oral fluid data

Postmortem Mitragynine Distribution in a Single Drug Fatality Case

Multiple drugs

Contact Info

Product

Resources

About